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Ophthalmic research2008; 40(3-4); 151-153; doi: 10.1159/000119867

Equine recurrent uveitis–a spontaneous horse model of uveitis.

Abstract: Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier.
2008 S. Karger AG, Basel.
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Publication Date: 2008-04-18 PubMed ID: 18421230DOI: 10.1159/000119867Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study focuses on equine recurrent uveitis (ERU), a common autoimmune disease in horses, to find insights into its human counterpart. The researchers have identified new autoantigens by comparing the protein patterns in the retinas of healthy horses and those with ERU.

Understanding Equine recurrent uveitis (ERU)

  • ERU is an autoimmune disease happening commonly in horses, with a prevalence of 10%. An autoimmune disease is a condition where the body’s immune system mistakenly attacks its own healthy cells.
  • This disease is repeatedly inflaming the uvea, the middle layer of the eye, affecting the horse’s vision, and potentially can lead to blindness if untreated.
  • ERU can serve as an effective model for studying human autoimmune uveitis due to its spontaneous occurrence and similarity to the human condition.

Identification and Analysis of Autoantigens

  • In this study, the researchers analysed the autoantibody-binding pattern of horses affected by ERU in comparison to that of the healthily retinal proteome. In other words, they identified the protein molecules which the malfunctioning immune system of horses produces to attack its own body cells.
  • The researchers successfully identified novel autoantigens, such as malate dehydrogenase, recoverin, and CRALBP (Cellular Retinaldehyde-binding Protein). These are proteins that stimulate the immune system to produce antibodies, leading to an autoimmune response.
  • Especially, the CRALBP protein seems to be a significant antigen also for human autoimmune uveitis, implicating that the study’s finding might contribute to developing treatments for the human disease.

Analysis of Differentially Regulated Proteins

  • The study includes proteomic screening, a method used to detect and measure the levels of different proteins, of vitreous and retinal samples from ERU affected cases compared to healthy controls.
  • This comparative analysis has led to the identification of a set of differentially regulated proteins essential to the immune system and the maintenance of the blood-retinal barrier, a part of the eye’s defense system that regulates the movement of ions, molecules, and cells between the bloodstream and the eye.
  • Knowing the proteins’ role in ERU could provide a biochemical insight, helping to design future therapeutic interventions.

Cite This Article

APA
Deeg CA, Hauck SM, Amann B, Pompetzki D, Altmann F, Raith A, Schmalzl T, Stangassinger M, Ueffing M. (2008). Equine recurrent uveitis–a spontaneous horse model of uveitis. Ophthalmic Res, 40(3-4), 151-153. https://doi.org/10.1159/000119867

Publication

Ophthalmic research
ISSN: 1423-0259
NlmUniqueID: 0267442
Country: Switzerland
Language: English
Volume: 40
Issue: 3-4
Pages: 151-153

Researcher Affiliations

Deeg, Cornelia A
  • Institute of Animal Physiology, LMU Munich, Munich, Germany. deeg@tiph.vetmed.uni-muenchen.de
Hauck, Stefanie M
    Amann, Barbara
      Pompetzki, Dirk
        Altmann, Frank
          Raith, Albert
            Schmalzl, Thomas
              Stangassinger, Manfred
                Ueffing, Marius

                  MeSH Terms

                  • Animals
                  • Autoantibodies / analysis
                  • Autoantigens / immunology
                  • Autoimmune Diseases / immunology
                  • Autoimmune Diseases / pathology
                  • Autoimmune Diseases / veterinary
                  • Disease Models, Animal
                  • Horse Diseases / immunology
                  • Horse Diseases / pathology
                  • Horses
                  • Humans
                  • Recurrence
                  • Retina / immunology
                  • Retina / pathology
                  • Uveitis / immunology
                  • Uveitis / pathology
                  • Uveitis / veterinary

                  References

                  This article includes 24 references

                  Citations

                  This article has been cited 31 times.
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