Equine sarcoids from Southern Italy: Molecular and Histopathological characterization.
Abstract: This study investigated the presence of δ bovine papillomaviruses (BPV-1, BPV-2, BPV-13, BPV-14) in equine skin lesions from Southern Italy, focusing on equine sarcoids and their histopathological correlations. 63 equine skin samples were analysed using PCR and sequencing for BPV detection, and their histopathological features were assessed. BPV DNA was detected in 69.84% of the samples, with BPV-1 and BPV-2 being the most prevalent genotype, followed by BPV-13, while BPV-14 was not detected. BPV DNA was also found in non-sarcoid tumours and non-neoplastic conditions. Histopathological analysis revealed in 41 samples typical sarcoid features: fibroblastic atypia and extracellular matrix deposition. Despite no statistical correlation was found between BPV genotypes and histopathological features, BPV-1 infection was associated with more severe fibroblastic atypia and abundant extracellular matrix. This study provides insights into the prevalence and potential pathogenic roles of different BPV genotypes in equine sarcoids and other skin lesions, underscoring the critical need for further research to develop targeted therapies.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication Date: 2025-06-19 PubMed ID: 40554817DOI: 10.1016/j.rvsc.2025.105777Google Scholar: Lookup
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- Journal Article
Cite This Article
APA
Martano M, Montagnaro S, Power K, Cuccaro B, Cutarelli A, Maiolino P, Restucci B.
(2025).
Equine sarcoids from Southern Italy: Molecular and Histopathological characterization.
Res Vet Sci, 193, 105777.
https://doi.org/10.1016/j.rvsc.2025.105777 Publication
Researcher Affiliations
- Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy. Electronic address: manuela.martano@unina.it.
- Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy. Electronic address: serena.montagnaro@unina.it.
- Department of Biology, University of Naples Federico II, Naples, Italy. Electronic address: karen.power@unina.it.
- Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy. Electronic address: bianca.cuccaro@unina.it.
- Department of Food Security Coordination, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, Naples, Italy. Electronic address: anna.cutarelli@izsmporti.it.
- Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy. Electronic address: paola.maiolino@unina.it.
- Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy. Electronic address: brunella.restucci@unina.it.
MeSH Terms
- Animals
- Horses
- Horse Diseases / virology
- Horse Diseases / pathology
- Horse Diseases / epidemiology
- Italy / epidemiology
- Skin Neoplasms / veterinary
- Skin Neoplasms / virology
- Skin Neoplasms / pathology
- Skin Neoplasms / epidemiology
- Papillomavirus Infections / veterinary
- Papillomavirus Infections / virology
- Papillomavirus Infections / pathology
- Papillomavirus Infections / epidemiology
- Bovine papillomavirus 1 / genetics
- Bovine papillomavirus 1 / isolation & purification
- Sarcoidosis / veterinary
- Sarcoidosis / virology
- Sarcoidosis / pathology
- Female
- Genotype
- Male
- DNA, Viral / genetics
- Polymerase Chain Reaction / veterinary
- Skin / pathology
- Skin / virology
Conflict of Interest Statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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