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Home / Equine Research Bank / J Virol / Equine tetherin blocks retrovirus release and its activity i...
Journal of virology2013; 88(2); 1259-1270; doi: 10.1128/JVI.03148-13

Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein.

Abstract: Human tetherin is a host restriction factor that inhibits replication of enveloped viruses by blocking viral release. Tetherin has an unusual topology that includes an N-terminal cytoplasmic tail, a single transmembrane domain, an extracellular domain, and a C-terminal glycosylphosphatidylinositol anchor. Tetherin is not well conserved across species, so it inhibits viral replication in a species-specific manner. Thus, studies of tetherin activities from different species provide an important tool for understanding its antiviral mechanism. Here, we report cloning of equine tetherin and characterization of its antiviral activity. Equine tetherin shares 53%, 40%, 36%, and 34% amino acid sequence identity with feline, human, simian, and murine tetherins, respectively. Like the feline tetherin, equine tetherin has a shorter N-terminal domain than human tetherin. Equine tetherin is localized on the cell surface and strongly blocks human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV) release from virus-producing cells. The antiviral activity of equine tetherin is neutralized by EIAV envelope protein, but not by the HIV-1 accessory protein Vpu, which is a human tetherin antagonist, and EIAV envelope protein does not counteract human tetherin. These results shed new light on our understanding of the species-specific tetherin antiviral mechanism.
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Publication Date: 2013-11-13 PubMed ID: 24227834PubMed Central: PMC3911658DOI: 10.1128/JVI.03148-13Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study discusses the isolation of equine tetherin, a cellular factor in horses that prevents the spread of certain enveloped viruses by inhibiting their release from cells. The researchers also studied the antiviral efficiency of equine tetherin, finding that it strongly inhibits HIV-1, SIV, and EIAV, with its activity being neutralized by EIAV envelope protein.

Antiviral Activity of Equine Tetherin

  • The authors report on the cloning and characterization of equine tetherin – a tetherin protein found in horses. Tetherin is an essential host factor that inhibits the replication of enveloped viruses by preventing their release from cells.
  • Equine tetherin shares some of its amino acid sequence with feline, human, simian, and murine tetherins, but there are also significant differences in the sequence, leading to differing lengths of the N-terminal domain.
  • Equine tetherin was found to be localized on the cell surface, where it serves its function of blocking the release of viruses.

The Inhibitory Effect of Equine Tetherin

  • The study found that equine tetherin is particularly effective in blocking the release of several varieties of viruses, including the human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV).
  • It’s important to note, however, that this antiviral activity can be neutralized by certain proteins on the viral envelope, specifically the EIAV envelope protein.

Species-Specific Antiviral Mechanism

  • The research enlightens about species-specific tetherin antiviral mechanism, due to variations between the tetherin proteins of different species. For instance, HIV-1 protein Vpu, a known antagonist of human tetherin, does not counteract equine tetherin. Conversely, EIAV envelope protein does not counteract human tetherin but does neutralize equine tetherin.
  • These findings signify that the antiviral functionality of tetherin is species-dependent, underpinning the need for further research to understand its full mechanism.

Cite This Article

APA
Yin X, Hu Z, Gu Q, Wu X, Zheng YH, Wei P, Wang X. (2013). Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol, 88(2), 1259-1270. https://doi.org/10.1128/JVI.03148-13

Publication

Journal of virology
ISSN: 1098-5514
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 88
Issue: 2
Pages: 1259-1270

Researcher Affiliations

Yin, Xin
  • State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Harbin, China.
Hu, Zhe
    Gu, Qinyong
      Wu, Xingliang
        Zheng, Yong-Hui
          Wei, Ping
            Wang, Xiaojun

              MeSH Terms

              • Amino Acid Sequence
              • Animals
              • Antigens, CD / chemistry
              • Antigens, CD / genetics
              • Antigens, CD / metabolism
              • Base Sequence
              • Cats
              • Cell Line
              • Cloning, Molecular
              • Equine Infectious Anemia / genetics
              • Equine Infectious Anemia / metabolism
              • Equine Infectious Anemia / virology
              • Horses
              • Humans
              • Infectious Anemia Virus, Equine / genetics
              • Infectious Anemia Virus, Equine / physiology
              • Mice
              • Molecular Sequence Data
              • Retroviridae / genetics
              • Retroviridae / physiology
              • Sequence Alignment
              • Viral Envelope Proteins / genetics
              • Viral Envelope Proteins / metabolism
              • Virus Release

              References

              This article includes 57 references
              1. Neil SJ, Zang T, Bieniasz PD. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.. Nature 2008 Jan 24;451(7177):425-30.
                doi: 10.1038/nature06553pubmed: 18200009google scholar: lookup
              2. Pardieu C, Vigan R, Wilson SJ, Calvi A, Zang T, Bieniasz P, Kellam P, Towers GJ, Neil SJ. The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin.. PLoS Pathog 2010 Apr 15;6(4):e1000843.
                doi: 10.1371/journal.ppat.1000843pmc: PMC2855335pubmed: 20419159google scholar: lookup
              3. Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y, McNatt M, Hatziioannou T, Bieniasz PD. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.. J Virol 2009 Feb;83(4):1837-44.
                doi: 10.1128/JVI.02211-08pmc: PMC2643743pubmed: 19036818google scholar: lookup
              4. Kaletsky RL, Francica JR, Agrawal-Gamse C, Bates P. Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.. Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2886-91.
                doi: 10.1073/pnas.0811014106pmc: PMC2650360pubmed: 19179289google scholar: lookup
              5. Sakuma T, Noda T, Urata S, Kawaoka Y, Yasuda J. Inhibition of Lassa and Marburg virus production by tetherin.. J Virol 2009 Mar;83(5):2382-5.
                doi: 10.1128/JVI.01607-08pmc: PMC2643706pubmed: 19091864google scholar: lookup
              6. Mansouri M, Viswanathan K, Douglas JL, Hines J, Gustin J, Moses AV, Früh K. Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus.. J Virol 2009 Oct;83(19):9672-81.
                doi: 10.1128/JVI.00597-09pmc: PMC2748026pubmed: 19605472google scholar: lookup
              7. Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S. Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.. J Virol 2010 Oct;84(20):10569-80.
                doi: 10.1128/JVI.00103-10pmc: PMC2950602pubmed: 20686043google scholar: lookup
              8. Jones PH, Mehta HV, Maric M, Roller RJ, Okeoma CM. Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo.. Retrovirology 2012 Jan 27;9:10.
                doi: 10.1186/1742-4690-9-10pmc: PMC3283513pubmed: 22284121google scholar: lookup
              9. Weidner JM, Jiang D, Pan XB, Chang J, Block TM, Guo JT. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.. J Virol 2010 Dec;84(24):12646-57.
                doi: 10.1128/JVI.01328-10pmc: PMC3004348pubmed: 20943977google scholar: lookup
              10. Mattiuzzo G, Ivol S, Takeuchi Y. Regulation of porcine endogenous retrovirus release by porcine and human tetherins.. J Virol 2010 Mar;84(5):2618-22.
                doi: 10.1128/JVI.01928-09pmc: PMC2820912pubmed: 20015985google scholar: lookup
              11. Arnaud F, Black SG, Murphy L, Griffiths DJ, Neil SJ, Spencer TE, Palmarini M. Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses.. J Virol 2010 May;84(9):4415-25.
                doi: 10.1128/JVI.00029-10pmc: PMC2863748pubmed: 20181686google scholar: lookup
              12. Liberatore RA, Bieniasz PD. Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo.. Proc Natl Acad Sci U S A 2011 Nov 1;108(44):18097-101.
                doi: 10.1073/pnas.1113694108pmc: PMC3207693pubmed: 22025715google scholar: lookup
              13. Goffinet C, Schmidt S, Kern C, Oberbremer L, Keppler OT. Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.. J Virol 2010 Nov;84(21):11374-84.
                doi: 10.1128/JVI.01067-10pmc: PMC2953199pubmed: 20702620google scholar: lookup
              14. Fukuma A, Abe M, Morikawa Y, Miyazawa T, Yasuda J. Cloning and characterization of the antiviral activity of feline Tetherin/BST-2.. PLoS One 2011 Mar 29;6(3):e18247.
                doi: 10.1371/journal.pone.0018247pmc: PMC3066219pubmed: 21479233google scholar: lookup
              15. Dietrich I, McMonagle EL, Petit SJ, Vijayakrishnan S, Logan N, Chan CN, Towers GJ, Hosie MJ, Willett BJ. Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection.. J Virol 2011 Jun;85(12):5840-52.
                doi: 10.1128/JVI.00071-11pmc: PMC3126296pubmed: 21490095google scholar: lookup
              16. Celestino M, Calistri A, Del Vecchio C, Salata C, Chiuppesi F, Pistello M, Borsetti A, Palù G, Parolin C. Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein.. J Virol 2012 Jun;86(12):6688-700.
                doi: 10.1128/JVI.07037-11pmc: PMC3393548pubmed: 22514338google scholar: lookup
              17. Barrett BS, Smith DS, Li SX, Guo K, Hasenkrug KJ, Santiago ML. A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.. PLoS Pathog 2012;8(3):e1002596.
                doi: 10.1371/journal.ppat.1002596pmc: PMC3310811pubmed: 22457621google scholar: lookup
              18. Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, Banting G. Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology.. Traffic 2003 Oct;4(10):694-709.
                doi: 10.1034/j.1600-0854.2003.00129.xpubmed: 12956872google scholar: lookup
              19. Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.. J Mol Biol 1999 Oct 1;292(4):797-817.
                doi: 10.1006/jmbi.1999.3108pubmed: 10525406google scholar: lookup
              20. Perez-Caballero D, Zang T, Ebrahimi A, McNatt MW, Gregory DA, Johnson MC, Bieniasz PD. Tetherin inhibits HIV-1 release by directly tethering virions to cells.. Cell 2009 Oct 30;139(3):499-511.
                doi: 10.1016/j.cell.2009.08.039pmc: PMC2844890pubmed: 19879838google scholar: lookup
              21. Ishikawa J, Kaisho T, Tomizawa H, Lee BO, Kobune Y, Inazawa J, Oritani K, Itoh M, Ochi T, Ishihara K. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.. Genomics 1995 Apr 10;26(3):527-34.
                doi: 10.1016/0888-7543(95)80171-Hpubmed: 7607676google scholar: lookup
              22. Vidal-Laliena M, Romero X, March S, Requena V, Petriz J, Engel P. Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry.. Cell Immunol 2005 Jul-Aug;236(1-2):6-16.
                doi: 10.1016/j.cellimm.2005.08.002pubmed: 16157322google scholar: lookup
              23. Blasius AL, Giurisato E, Cella M, Schreiber RD, Shaw AS, Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation.. J Immunol 2006 Sep 1;177(5):3260-5.
                pubmed: 16920966doi: 10.4049/jimmunol.177.5.3260google scholar: lookup
              24. Mangeat B, Gers-Huber G, Lehmann M, Zufferey M, Luban J, Piguet V. HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.. PLoS Pathog 2009 Sep;5(9):e1000574.
                doi: 10.1371/journal.ppat.1000574pmc: PMC2729927pubmed: 19730691google scholar: lookup
              25. Miyagi E, Andrew AJ, Kao S, Strebel K. Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion.. Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2868-73.
                doi: 10.1073/pnas.0813223106pmc: PMC2650357pubmed: 19196977google scholar: lookup
              26. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.. Cell Host Microbe 2008 Apr 17;3(4):245-52.
                doi: 10.1016/j.chom.2008.03.001pmc: PMC2474773pubmed: 18342597google scholar: lookup
              27. Rong L, Zhang J, Lu J, Pan Q, Lorgeoux RP, Aloysius C, Guo F, Liu SL, Wainberg MA, Liang C. The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu.. J Virol 2009 Aug;83(15):7536-46.
                doi: 10.1128/JVI.00620-09pmc: PMC2708638pubmed: 19474106google scholar: lookup
              28. Erikson E, Adam T, Schmidt S, Lehmann-Koch J, Over B, Goffinet C, Harter C, Bekeredjian-Ding I, Sertel S, Lasitschka F, Keppler OT. In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans.. Proc Natl Acad Sci U S A 2011 Aug 16;108(33):13688-93.
                doi: 10.1073/pnas.1101684108pmc: PMC3158195pubmed: 21808013google scholar: lookup
              29. Le Tortorec A, Neil SJ. Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.. J Virol 2009 Nov;83(22):11966-78.
                doi: 10.1128/JVI.01515-09pmc: PMC2772693pubmed: 19740980google scholar: lookup
              30. Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment.. Retrovirology 2010 Jun 7;7:51.
                doi: 10.1186/1742-4690-7-51pmc: PMC2890665pubmed: 20529266google scholar: lookup
              31. Gupta RK, Mlcochova P, Pelchen-Matthews A, Petit SJ, Mattiuzzo G, Pillay D, Takeuchi Y, Marsh M, Towers GJ. Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration.. Proc Natl Acad Sci U S A 2009 Dec 8;106(49):20889-94.
                doi: 10.1073/pnas.0907075106pmc: PMC2791628pubmed: 19864625google scholar: lookup
              32. Lopez LA, Yang SJ, Hauser H, Exline CM, Haworth KG, Oldenburg J, Cannon PM. Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal.. J Virol 2010 Jul;84(14):7243-55.
                doi: 10.1128/JVI.02636-09pmc: PMC2898217pubmed: 20444895google scholar: lookup
              33. Leroux C, Cadoré JL, Montelaro RC. Equine Infectious Anemia Virus (EIAV): what has HIV's country cousin got to tell us?. Vet Res 2004 Jul-Aug;35(4):485-512.
                doi: 10.1051/vetres:2004020pubmed: 15236678google scholar: lookup
              34. Leroux C, Craigo JK, Issel CJ, Montelaro RC. Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies.. J Virol 2001 May;75(10):4570-83.
                doi: 10.1128/JVI.75.10.4570-4583.2001pmc: PMC114210pubmed: 11312327google scholar: lookup
              35. Hammonds J, Wang JJ, Yi H, Spearman P. Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane.. PLoS Pathog 2010 Feb 5;6(2):e1000749.
                doi: 10.1371/journal.ppat.1000749pmc: PMC2816691pubmed: 20140192google scholar: lookup
              36. Zheng YH, Jeang KT, Tokunaga K. Host restriction factors in retroviral infection: promises in virus-host interaction.. Retrovirology 2012 Dec 20;9:112.
                doi: 10.1186/1742-4690-9-112pmc: PMC3549941pubmed: 23254112google scholar: lookup
              37. Malim MH, Bieniasz PD. HIV Restriction Factors and Mechanisms of Evasion.. Cold Spring Harb Perspect Med 2012 May;2(5):a006940.
                doi: 10.1101/cshperspect.a006940pmc: PMC3331687pubmed: 22553496google scholar: lookup
              38. Mitrophanous K, Yoon S, Rohll J, Patil D, Wilkes F, Kim V, Kingsman S, Kingsman A, Mazarakis N. Stable gene transfer to the nervous system using a non-primate lentiviral vector.. Gene Ther 1999 Nov;6(11):1808-18.
                doi: 10.1038/sj.gt.3301023pubmed: 10602376google scholar: lookup
              39. Balaggan KS, Binley K, Esapa M, Iqball S, Askham Z, Kan O, Tschernutter M, Bainbridge JW, Naylor S, Ali RR. Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors.. J Gene Med 2006 Mar;8(3):275-85.
                doi: 10.1002/jgm.845pubmed: 16299834google scholar: lookup
              40. Zielonka J, Bravo IG, Marino D, Conrad E, Perković M, Battenberg M, Cichutek K, Münk C. Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.. J Virol 2009 Aug;83(15):7547-59.
                doi: 10.1128/JVI.00015-09pmc: PMC2708611pubmed: 19458006google scholar: lookup
              41. Bogerd HP, Tallmadge RL, Oaks JL, Carpenter S, Cullen BR. Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.. J Virol 2008 Dec;82(23):11889-901.
                doi: 10.1128/JVI.01537-08pmc: PMC2583693pubmed: 18818324google scholar: lookup
              42. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. BST-2/tetherin: a new component of the innate immune response to enveloped viruses.. Trends Microbiol 2010 Sep;18(9):388-96.
                doi: 10.1016/j.tim.2010.06.010pmc: PMC2956607pubmed: 20688520google scholar: lookup
              43. Masuyama N, Kuronita T, Tanaka R, Muto T, Hirota Y, Takigawa A, Fujita H, Aso Y, Amano J, Tanaka Y. HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin.. J Biol Chem 2009 Jun 5;284(23):15927-41.
                doi: 10.1074/jbc.M109.005124pmc: PMC2708888pubmed: 19359243google scholar: lookup
              44. Rollason R, Korolchuk V, Hamilton C, Schu P, Banting G. Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif.. J Cell Sci 2007 Nov 1;120(Pt 21):3850-8.
                doi: 10.1242/jcs.003343pubmed: 17940069google scholar: lookup
              45. Boucrot E, Saffarian S, Zhang R, Kirchhausen T. Roles of AP-2 in clathrin-mediated endocytosis.. PLoS One 2010 May 12;5(5):e10597.
                doi: 10.1371/journal.pone.0010597pmc: PMC2868873pubmed: 20485680google scholar: lookup
              46. Dubé M, Roy BB, Guiot-Guillain P, Binette J, Mercier J, Chiasson A, Cohen EA. Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.. PLoS Pathog 2010 Apr 8;6(4):e1000856.
                doi: 10.1371/journal.ppat.1000856pmc: PMC2851737pubmed: 20386718google scholar: lookup
              47. Habermann A, Krijnse-Locker J, Oberwinkler H, Eckhardt M, Homann S, Andrew A, Strebel K, Kräusslich HG. CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection.. J Virol 2010 May;84(9):4646-58.
                doi: 10.1128/JVI.02421-09pmc: PMC2863769pubmed: 20147389google scholar: lookup
              48. Andrew AJ, Miyagi E, Kao S, Strebel K. The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu.. Retrovirology 2009 Sep 8;6:80.
                doi: 10.1186/1742-4690-6-80pmc: PMC2754425pubmed: 19737401google scholar: lookup
              49. Neil SJ, Sandrin V, Sundquist WI, Bieniasz PD. An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein.. Cell Host Microbe 2007 Sep 13;2(3):193-203.
                doi: 10.1016/j.chom.2007.08.001pmc: PMC3793644pubmed: 18005734google scholar: lookup
              50. Jia B, Serra-Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana IB, Johnson WE, Westmoreland S, Evans DT. Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.. PLoS Pathog 2009 May;5(5):e1000429.
                doi: 10.1371/journal.ppat.1000429pmc: PMC2673686pubmed: 19436700google scholar: lookup
              51. McNatt MW, Zang T, Hatziioannou T, Bartlett M, Fofana IB, Johnson WE, Neil SJ, Bieniasz PD. Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants.. PLoS Pathog 2009 Feb;5(2):e1000300.
                doi: 10.1371/journal.ppat.1000300pmc: PMC2633611pubmed: 19214216google scholar: lookup
              52. Goffinet C, Allespach I, Homann S, Tervo HM, Habermann A, Rupp D, Oberbremer L, Kern C, Tibroni N, Welsch S, Krijnse-Locker J, Banting G, Kräusslich HG, Fackler OT, Keppler OT. HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.. Cell Host Microbe 2009 Mar 19;5(3):285-97.
                doi: 10.1016/j.chom.2009.01.009pubmed: 19286137google scholar: lookup
              53. Tokarev AA, Munguia J, Guatelli JC. Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.. J Virol 2011 Jan;85(1):51-63.
                doi: 10.1128/JVI.01795-10pmc: PMC3014196pubmed: 20980512google scholar: lookup
              54. Fagerness AJ, Flaherty MT, Perry ST, Jia B, Payne SL, Fuller FJ. The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies.. Virology 2006 May 25;349(1):22-30.
                doi: 10.1016/j.virol.2005.12.041pubmed: 16503341google scholar: lookup
              55. Li F, Leroux C, Craigo JK, Cook SJ, Issel CJ, Montelaro RC. The S2 gene of equine infectious anemia virus is a highly conserved determinant of viral replication and virulence properties in experimentally infected ponies.. J Virol 2000 Jan;74(1):573-9.
                doi: 10.1128/JVI.74.1.573-579.2000pmc: PMC111574pubmed: 10590152google scholar: lookup
              56. Li F, Puffer BA, Montelaro RC. The S2 gene of equine infectious anemia virus is dispensable for viral replication in vitro.. J Virol 1998 Oct;72(10):8344-8.
                pmc: PMC110207pubmed: 9733881doi: 10.1128/JVI.72.10.8344-8348.1998google scholar: lookup
              57. Kühl A, Banning C, Marzi A, Votteler J, Steffen I, Bertram S, Glowacka I, Konrad A, Stürzl M, Guo JT, Schubert U, Feldmann H, Behrens G, Schindler M, Pöhlmann S. The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin.. J Infect Dis 2011 Nov;204 Suppl 3(Suppl 3):S850-60.
                doi: 10.1093/infdis/jir378pmc: PMC3189996pubmed: 21987761google scholar: lookup

              Citations

              This article has been cited 28 times.
              1. Wang XF, Zhang X, Ma W, Li J, Wang X. Host cell restriction factors of equine infectious anemia virus.. Virol Sin 2023 Aug;38(4):485-496.
                doi: 10.1016/j.virs.2023.07.001pubmed: 37419416google scholar: lookup
              2. Mann MM, Hsieh MK, Tang JD, Hart WS, Lazzara MJ, Klauda JB, Berger BW. Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a.. Biochim Biophys Acta Biomembr 2023 Aug;1865(6):184174.
                doi: 10.1016/j.bbamem.2023.184174pubmed: 37211321google scholar: lookup
              3. Morrison JH, Poeschla EM. The Feline Immunodeficiency Virus Envelope Signal Peptide Is a Tetherin Antagonizing Protein.. mBio 2023 Apr 25;14(2):e0016123.
                doi: 10.1128/mbio.00161-23pubmed: 36927083google scholar: lookup
              4. Duan Y, Wang X, Sun K, Lin Y, Wang X, Chen K, Yang G, Wang X, Du C. SYNJ2BP Improves the Production of Lentiviral Envelope Protein by Facilitating the Formation of Mitochondrion-Associated Endoplasmic Reticulum Membrane.. J Virol 2022 Oct 26;96(20):e0054922.
                doi: 10.1128/jvi.00549-22pubmed: 36197105google scholar: lookup
              5. Wang Y, Ma G, Wang XF, Na L, Guo X, Zhang J, Liu C, Du C, Qi T, Lin Y, Wang X. Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense.. PLoS Pathog 2022 Feb;18(2):e1009986.
                doi: 10.1371/journal.ppat.1009986pubmed: 35139135google scholar: lookup
              6. Ren H, Yin X, Su C, Guo M, Wang XF, Na L, Lin Y, Wang X. Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway.. Autophagy 2021 Oct;17(10):2800-2817.
                doi: 10.1080/15548627.2020.1846301pubmed: 33172327google scholar: lookup
              7. Waheed AA, Swiderski M, Khan A, Gitzen A, Majadly A, Freed EO. The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.. J Biol Chem 2020 May 22;295(21):7327-7340.
                doi: 10.1074/jbc.RA120.013280pubmed: 32291285google scholar: lookup
              8. Bai B, Wang XF, Zhang M, Na L, Zhang X, Zhang H, Yang Z, Wang X. The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.. Viruses 2020 Feb 16;12(2).
                doi: 10.3390/v12020220pubmed: 32079099google scholar: lookup
              9. Wang XF, Bai B, Lin Y, Qi T, Du C, Song M, Wang X. High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone.. Virol Sin 2019 Dec;34(6):725-728.
                doi: 10.1007/s12250-019-00153-wpubmed: 31376080google scholar: lookup
              10. de Pablo-Maiso L, Doménech A, Echeverría I, Gómez-Arrebola C, de Andrés D, Rosati S, Gómez-Lucia E, Reina R. Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses.. Viruses 2018 Aug 17;10(8).
                doi: 10.3390/v10080435pubmed: 30126090google scholar: lookup
              11. Heusinger E, Deppe K, Sette P, Krapp C, Kmiec D, Kluge SF, Marx PA, Apetrei C, Kirchhoff F, Sauter D. Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2.. J Virol 2018 Sep 15;92(18).
                doi: 10.1128/JVI.00276-18pubmed: 29976668google scholar: lookup
              12. Wang M, Zhang Z, Wang X. Strain-Specific Antagonism of the Human H1N1 Influenza A Virus against Equine Tetherin.. Viruses 2018 May 16;10(5).
                doi: 10.3390/v10050264pubmed: 29772683google scholar: lookup
              13. Ji S, Na L, Ren H, Wang Y, Wang X. Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein.. J Virol 2018 Sep 15;92(18).
                doi: 10.1128/JVI.00499-18pubmed: 29743377google scholar: lookup
              14. Wang HN, Rao D, Fu XQ, Hu MM, Dong JG. Equine infectious anemia virus in China.. Oncotarget 2018 Jan 2;9(1):1356-1364.
                doi: 10.18632/oncotarget.20381pubmed: 29416700google scholar: lookup
              15. Liang Z, Zhang Y, Song J, Zhang H, Zhang S, Li Y, Tan J, Qiao W. The effect of bovine BST2A1 on the release and cell-to-cell transmission of retroviruses.. Virol J 2017 Sep 6;14(1):173.
                doi: 10.1186/s12985-017-0835-0pubmed: 28877726google scholar: lookup
              16. Chen CY, Shingai M, Welbourn S, Martin MA, Borrego P, Taveira N, Strebel K. Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates.. J Virol 2016 Dec 15;90(24):11062-11074.
                doi: 10.1128/JVI.01451-16pubmed: 27681141google scholar: lookup
              17. Mahauad-Fernandez WD, Okeoma CM. The role of BST-2/Tetherin in host protection and disease manifestation.. Immun Inflamm Dis 2016 Mar;4(1):4-23.
                doi: 10.1002/iid3.92pubmed: 27042298google scholar: lookup
              18. Nishitsuji H, Sugiyama R, Abe M, Takaku H. ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor κ Light Chain Enhancer of Activated B Cells (NF-κB) Activation by BST-2.. J Biol Chem 2016 Feb 26;291(9):4754-62.
                doi: 10.1074/jbc.M115.679357pubmed: 26694617google scholar: lookup
              19. Takeuchi JS, Ren F, Yoshikawa R, Yamada E, Nakano Y, Kobayashi T, Matsuda K, Izumi T, Misawa N, Shintaku Y, Wetzel KS, Collman RG, Tanaka H, Hirsch VM, Koyanagi Y, Sato K. Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.. Sci Rep 2015 Nov 4;5:16021.
                doi: 10.1038/srep16021pubmed: 26531727google scholar: lookup
              20. Gnirß K, Zmora P, Blazejewska P, Winkler M, Lins A, Nehlmeier I, Gärtner S, Moldenhauer AS, Hofmann-Winkler H, Wolff T, Schindler M, Pöhlmann S. Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.. J Virol 2015 Sep;89(18):9178-88.
                doi: 10.1128/JVI.00615-15pubmed: 26109730google scholar: lookup
              21. Tedbury PR, Freed EO. The cytoplasmic tail of retroviral envelope glycoproteins.. Prog Mol Biol Transl Sci 2015;129:253-84.
                doi: 10.1016/bs.pmbts.2014.10.009pubmed: 25595807google scholar: lookup
              22. Waheed AA, Kuruppu ND, Felton KL, D'Souza D, Freed EO. In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.. PLoS One 2014;9(10):e111628.
                doi: 10.1371/journal.pone.0111628pubmed: 25360760google scholar: lookup
              23. Lemaître C, Harper F, Pierron G, Heidmann T, Dewannieux M. The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activity.. J Virol 2014 Dec;88(23):13626-37.
                doi: 10.1128/JVI.02234-14pubmed: 25210194google scholar: lookup
              24. Yin X, Guo M, Gu Q, Wu X, Wei P, Wang X. Antiviral potency and functional analysis of tetherin orthologues encoded by horse and donkey.. Virol J 2014 Aug 27;11:151.
                doi: 10.1186/1743-422X-11-151pubmed: 25158826google scholar: lookup
              25. Tang YD, Na L, Zhu CH, Shen N, Yang F, Fu XQ, Wang YH, Fu LH, Wang JY, Lin YZ, Wang XF, Wang X, Zhou JH, Li CY. Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.. J Virol 2014 Nov;88(21):12296-310.
                doi: 10.1128/JVI.01379-14pubmed: 25122784google scholar: lookup
              26. Ai Y, Zhu D, Wang C, Su C, Ma J, Ma J, Wang X. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation.. J Virol 2014 Oct;88(20):12112-22.
                doi: 10.1128/JVI.01924-14pubmed: 25122780google scholar: lookup
              27. Sauter D. Counteraction of the multifunctional restriction factor tetherin.. Front Microbiol 2014;5:163.
                doi: 10.3389/fmicb.2014.00163pubmed: 24782851google scholar: lookup
              28. Weinelt J, Neil SJ. Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.. J Virol 2014 May;88(10):5845-58.
                doi: 10.1128/JVI.03818-13pubmed: 24623426google scholar: lookup
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