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Experimental physiology2000; 85(5); 539-545;

Equine uteroplacental metabolism at mid- and late gestation.

Abstract: Uptakes of oxygen, glucose and lactate by the gravid uterus, fetus and uteroplacental tissues were measured in chronically catheterized pregnant ponies and their fetuses at mid- and late gestation (term 335 days). Rates of O2 uptake by the gravid uterus, fetus and uteroplacental tissues were significant at both gestational ages and were 2- to 3-fold higher in late gestation than the mid-gestation values of 3338+/-794, 1352+/-258 and 2035 +/- 602 micromol min(-1), respectively (n = 4). Similarly, there were significant uptakes of glucose by the gravid uterus, fetus and uteroplacental tissues at both mid- and late gestation. However, unlike O2 uptake, glucose uptake by the uterus and uteroplacental tissues did not increase between mid- and late gestation. No significant uptakes or outputs of lactate were observed by the uterus or uteroplacental tissues at either gestational age, although there was a significant umbilical uptake of lactate in late but not mid-gestation. There was no change in the distribution of uterine O2 uptake between the fetus and uteroplacental tissues with increasing gestational age. The uteroplacental tissues accounted for about 50 % of the uterine O2 uptake at both gestational ages. In contrast, the proportion of the uterine glucose uptake used by the uteroplacental tissues decreased from 73.2+/-2.1 % (n = 5) at mid-gestation to 61.1+/-1.9 % (n = 4, P<0.02) in late gestation. The gestational changes in uteroplacental carbohydrate metabolism in the mare differ from those seen in the ewe and may have important consequences for the duration and outcome of pregnancy in the mare.
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Publication Date: 2000-10-20 PubMed ID: 11038405
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on studying rates of oxygen, glucose and lactate uptake by the uterus, fetus and uteroplacental tissues in pregnant ponies at mid-and late gestation to understand the changes in uteroplacental carbohydrate metabolism and the possible impact these changes may have on the duration and outcome of pregnancy in mares.

Methodology

  • The study was conducted on chronically catheterized pregnant ponies and their fetuses at both mid- and late gestation.
  • Uptake rates of Oxygen (O2), glucose and lactate by the gravid uterus, fetus and uteroplacental tissues were measured.
  • The study recorded metrics at two different stages of gestation – mid-gestation and late gestation (term 335 days) – and compared the changes between these two stages.

Findings

  • Oxygen uptake rates by the gravid uterus, fetus and uteroplacental tissues were found to increase 2 to 3 times in the late gestation stage as compared to mid-gestation.
  • Significant uptakes of glucose by the uterus, fetus and uteroplacental tissues were observed at both gestation stages. However, unlike oxygen uptake, glucose uptake did not increase from the mid- to late-gestation period.
  • No significant uptakes or outputs of lactate were observed by the uterus or uteroplacental tissues at either stage, though there was a significant umbilical uptake of lactate in late gestation but not in mid-gestation.
  • There were no changes in the division of uterine oxygen uptake between the fetus and uteroplacental tissues with increasing gestational age, with uteroplacental tissues accounting for about half of the uterine oxygen uptake at both gestational stages.
  • The proportion of the uterine glucose uptake used by the uteroplacental tissues decreased from 73.2% at mid-gestation to 61.1% at late gestation.

Conclusion

  • The results indicate clear gestational changes in uteroplacental carbohydrate metabolism in mares.
  • The variations in uteroplacental carbohydrate metabolism observed in this study are different from changes seen in ewes.
  • The results imply that the changes in uteroplacental metabolism seen in this study could have important consequences for the duration and outcome of pregnancy in mares.

Cite This Article

APA
Fowden AL, Forhead AJ, White KL, Taylor PM. (2000). Equine uteroplacental metabolism at mid- and late gestation. Exp Physiol, 85(5), 539-545.

Publication

Experimental physiology
ISSN: 0958-0670
NlmUniqueID: 9002940
Country: England
Language: English
Volume: 85
Issue: 5
Pages: 539-545

Researcher Affiliations

Fowden, A L
  • Departments of Physiology and Clinical Veterinary Medicine, University of Cambridge, Cambridge CB2 3EG, UK.
Forhead, A J
    White, K L
      Taylor, P M

        MeSH Terms

        • Animals
        • Blood Glucose / analysis
        • Blood Glucose / metabolism
        • Female
        • Fetal Blood / chemistry
        • Fetal Blood / metabolism
        • Fetal Weight
        • Fetus / blood supply
        • Fetus / metabolism
        • Gestational Age
        • Horses / metabolism
        • Lactic Acid / blood
        • Lactic Acid / metabolism
        • Oxygen / blood
        • Oxygen / metabolism
        • Oxygen Consumption
        • Placenta / blood supply
        • Placenta / metabolism
        • Placental Circulation / physiology
        • Pregnancy
        • Sheep / metabolism
        • Uterus / blood supply
        • Uterus / metabolism

        Citations

        This article has been cited 5 times.
        1. Zhang L, Tan C, Xin Z, Huang S, Ma J, Zhang M, Shu G, Luo H, Deng B, Jiang Q, Deng J. UPLC-Orbitrap-MS/MS Combined With Biochemical Analysis to Determine the Growth and Development of Mothers and Fetuses in Different Gestation Periods on Tibetan Sow Model. Front Nutr 2022;9:836938.
          doi: 10.3389/fnut.2022.836938pubmed: 35425793google scholar: lookup
        2. Brunst KJ, Hsu HL, Zhang L, Zhang X, Carroll KN, Just A, Coull BA, Kloog I, Wright RO, Baccarelli AA, Wright RJ. Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry. Mitochondrion 2022 Jan;62:102-110.
          doi: 10.1016/j.mito.2021.11.003pubmed: 34785263google scholar: lookup
        3. Robles M, Couturier-Tarrade A, Derisoud E, Geeverding A, Dubois C, Dahirel M, Aioun J, Prezelin A, Calvez J, Richard C, Wimel L, Chavatte-Palmer P. Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth. Sci Rep 2019 Apr 23;9(1):6461.
          doi: 10.1038/s41598-019-42941-0pubmed: 31015538google scholar: lookup
        4. Sferruzzi-Perri AN, Higgins JS, Vaughan OR, Murray AJ, Fowden AL. Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. Proc Natl Acad Sci U S A 2019 Jan 29;116(5):1621-1626.
          doi: 10.1073/pnas.1816056116pubmed: 30655345google scholar: lookup
        5. Giussani DA, Forhead AJ, Fowden AL. Development of cardiovascular function in the horse fetus. J Physiol 2005 Jun 15;565(Pt 3):1019-30.
          doi: 10.1113/jphysiol.2004.078469pubmed: 15790668google scholar: lookup
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