The Veterinary clinics of North America. Equine practice1993; 9(2); 295-309; doi: 10.1016/s0749-0739(17)30397-8

Equine viral arteritis.

Abstract: Equine viral arteritis is an infrequently encountered contagious viral disease of equids that has assumed increased veterinary medical and economic significance since the 1984 epidemic in Thoroughbreds in Kentucky. The most important consequences of this infection are abortion in the mare and establishment of the carrier state in the stallion. Equine arteritis virus becomes localized in the reproductive tract of a relatively high percentage of infected stallions which serve as very efficient transmitters of the infection through direct or indirect venereal contact with susceptible mares. The long-term persistently infected stallion appears to play a major epidemiologic role in the dissemination and perpetuation of the virus in horse populations throughout the world. Aspects of the pathogenesis, immunity, and epidemiology of equine arteritis virus are discussed in relation to current methods for the diagnosis, treatment, and control of this disease.
Publication Date: 1993-08-01 PubMed ID: 8395325PubMed Central: PMC7134676DOI: 10.1016/s0749-0739(17)30397-8Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on equine viral arteritis, a contagious infection affecting horses, and discusses its impacts, transmission, epidemiology and current strategies for diagnosis, treatment and prevention.

Overview of Equine Viral Arteritis

  • Equine viral arteritis is explained as a contagious viral infection occurring sporadically in horses and has gained significant attention within veterinary medicine and the economy mainly due to a major outbreak in 1984 amongst Thoroughbreds in Kentucky.
  • The illness is particularly concerning due to two critical outcomes: firstly, it can cause mares to abort, and secondly, it can create a carrier state in stallions, making them long-term transmitters of the virus.

Transmission of the Virus

  • The study reveals that the virus tends to become established in a high percentage of infected stallions’ reproductive tracts.
  • These stallions, once infected, morph into highly potent sources of the infection, passing on the virus to susceptible mares either directly or indirectly. The paper indicates that venereal contact is a common mode of transmission.

Epidemiology and Spread of the Virus

  • The report points out that long-term carriers of equine arteritis virus – mainly stallions – have a prominent role in spreading and maintaining the virus across horse populations globally, impacting epidemiological outcomes.

Pathogenesis and Immunity

  • Aspects of the pathogenesis (how the virus causes disease) and immunity are discussed in this study. However, without more details, it is unclear what conclusions or findings the paper has on these specific areas. It may relate to how the virus interacts with the horses’ immune system and the clinical symptoms associated with infection.

Diagnosis, Treatment, and Control of the Disease

  • The paper mentions current methods of diagnosing, treating, and controlling equine viral arteritis but doesn’t provide further details. These approaches could encompass a range of strategies from laboratory testing and medical therapies to vaccination and quarantining measures.

Cite This Article

APA
Timoney PJ, McCollum WH. (1993). Equine viral arteritis. Vet Clin North Am Equine Pract, 9(2), 295-309. https://doi.org/10.1016/s0749-0739(17)30397-8

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 9
Issue: 2
Pages: 295-309

Researcher Affiliations

Timoney, P J
  • Department of Veterinary Sciences, University of Kentucky, Lexington.
McCollum, W H

    MeSH Terms

    • Animals
    • Arteritis / veterinary
    • Carrier State / veterinary
    • Equartevirus
    • Female
    • Horse Diseases
    • Horses
    • Male
    • Virus Diseases / veterinary

    References

    This article includes 52 references
    1. Bergman A.M. Beitrage zur Kenntnis der Virustrager bei Rotlaufseuche, Influenza erisipelatosa, des Pferdes. Z Infecktionskrankh. 1913;13:161.
    2. Carman S, Rae C, Dubovi E. Ontario. Equine arteritis virus isolated from a Standardbred foal with pneumonia.. Can Vet J 1988 Nov;29(11):937.
      pmc: PMC1680932pubmed: 17423174
    3. Chirnside ED, Spaan WJ. Reverse transcription and cDNA amplification by the polymerase chain reaction of equine arteritis virus (EAV).. J Virol Methods 1990 Nov;30(2):133-40.
      pubmed: 1702094doi: 10.1016/0166-0934(90)90014-7google scholar: lookup
    4. Coignoul FL, Cheville NF. Pathology of maternal genital tract, placenta, and fetus in equine viral arteritis.. Vet Pathol 1984 May;21(3):333-40.
      pubmed: 6328724doi: 10.1177/030098588402100311google scholar: lookup
    5. Cole JR, Hall RF, Gosser HS, Hendricks JB, Pursell AR, Senne DA, Pearson JE, Gipson CA. Transmissibility and abortogenic effect of equine viral arteritis in mares.. J Am Vet Med Assoc 1986 Oct 1;189(7):769-71.
      pubmed: 3021696
    6. Collins J.K., Sari S., Ralston S.L. Equine viral arteritis at a veterinary teaching hospital. Prev Vet Med. 1987;4:389.
    7. Crawford TB, Henson JB: Immunofluorescent, light microscopic and immunologic studies of equine viral arteritis. In Proceedings of the Third International Conference of Equine Infectious Diseases, Paris, 1973, p 282
    8. den Boon JA, Snijder EJ, Chirnside ED, de Vries AA, Horzinek MC, Spaan WJ. Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily.. J Virol 1991 Jun;65(6):2910-20.
    9. BRYANS JT, CROWE ME, DOLL ER, MCCOLLUM WH. Isolation of a filterable agent causing arteritis of horses and abortion by mares; its differentiation from the equine abortion (influenza) virus.. Cornell Vet 1957 Jan;47(1):3-41.
      pubmed: 13397177
    10. Doll ER, Bryans JT, Wilson JC, McCollum WH. Immunization against equine viral arteritis using modified live virus propagated in cell cultures of rabbit kidney.. Cornell Vet 1968 Oct;48(4):497-524.
      pubmed: 4971878
    11. BRYANS JT, DOLL ER, KNAPPENBERGER RE. An outbreak of abortion caused by the equine arteritis virus.. Cornell Vet 1957 Jan;47(1):69-75.
      pubmed: 13397180
    12. Fukunaga Y., Imagawa H., Tabuchi E. Clinical and virological findings on experimental equine viral arteritis in horses. Bull Equine Res Inst. 1981;18:110.
    13. Fukunaga Y, McCollum WH. Complement-fixation reactions in equine viral arteritis.. Am J Vet Res 1977 Dec;38(12):2043-6.
      pubmed: 202179
    14. Geor RJ, Becker RL, Kanara EW, Hovda LR, Sweeney WH, Winter TF, Rorick JK, Ruth GR, Hope E, Murphy MJ. Toxicosis in horses after ingestion of hoary alyssum.. J Am Vet Med Assoc 1992 Jul 1;201(1):63-7.
      pubmed: 1644648
    15. Golnik W, Michalska Z, Michalak T. Natural equine viral arteritis in foals.. Schweiz Arch Tierheilkd 1981 Oct;123(10):523-33.
      pubmed: 6274007
    16. Holyoak GR, Little TV, McCollam WH, Timoney PJ. Relationship between onset of puberty and establishment of persistent infection with equine arteritis virus in the experimentally infected colt.. J Comp Pathol 1993 Jul;109(1):29-46.
    17. Johnson B, Baldwin C, Timoney P, Ely R. Arteritis in equine fetuses aborted due to equine viral arteritis.. Vet Pathol 1991 May;28(3):248-50.
      pubmed: 1650052doi: 10.1177/030098589102800310google scholar: lookup
    18. BRYANS JT, DOLL ER, JONES TC. The lesions of equine viral arteritis.. Cornell Vet 1957 Jan;47(1):52-68.
      pubmed: 13397179
    19. Little TV, Holyoak GR, McCollum WH, et al.: Output of equine arteritis virus from persistently infected stallions is testosterone-dependent. In Equine Infectious Diseases VI: Proceedings of the 6th International Conference, Cambridge, UK, 1991, p 225
    20. McCollum WH. Development of a modified virus strain and vaccine for equine viral arteritis.. J Am Vet Med Assoc 1969 Jul 15;155(2):318-22.
      pubmed: 4978804
    21. McCollum WH: Vaccination for equine viral arteritis. In Proceedings of the Second International Conference on Equine Infectious Diseases, Paris, 1970, p 143
    22. McCollum W.H. Studies of passive immunity in foals to equine viral arteritis. Vet Microbiol. 1976;1:45.
    23. McCollum WH, Bryans JT: Serological identification of infection by equine arteritis virus in horses of several countries. In Proceedings of the Third International Conference of Equine Infectious Diseases, Paris, 1972, p 256
    24. McCollum WH, Prickett ME, Bryans JT. Temporal distribution of equine arteritis virus in respiratory mucosa, tissues and body fluids of horses infected by inhalation.. Res Vet Sci 1971 Sep;12(5):459-64.
      pubmed: 4999643
    25. McCollum W.H., Swerczek T.W. Studies of an epizootic of equine viral arteritis in racehorses. J Equine Med Surg. 1978;2:293.
    26. McCollum WH, Timoney PJ: The pathogenic qualities of the 1984 strain of equine arteritis virus. In Proceedings of the Grayson Foundation International Conference of Thoroughbred Breeders Organizations, Drumoland Castle, Ireland, 1984, p 34
    27. McCollum W.H., Timoney P.J., Roberts A.W. Response of vaccinated and non-vaccinated mares to artificial insemination with semen from stallions persistently infected with equine arteritis virus. In: Powell D.G., editor. Equine Infectious Diseases V: Proceedings of the Fifth International Conference. University Press of Kentucky; Lexington, KY: 1987. p. 13.
    28. McCue P.M., Hietala S.K., Spensely M.S. Prevalence of equine viral arteritis in California horses. California Veterinarian. 1991;45:24.
    29. McGuire TC, Crawford TB, Henson JB. Prevalence of antibodies to herpesvirus types 1 and 2, arteritis and infectious anemia viral antigens in equine serum.. Am J Vet Res 1974 Feb;35(2):181-5.
      pubmed: 4360338
    30. McKinnon A.O., Colbern G.T., Collins J.K. Vaccination of stallions with a modified live equine arteritis virus vaccine. J Equine Vet Sci. 1986;6:66.
    31. Moraillon A, Moraillon R. Results of an epidemiological investigation on viral arteritis in France and some other European and African countries.. Ann Rech Vet 1978;9(1):43-54.
      pubmed: 213008
    32. Murphy T.W., Timoney P.J., McCollum W.H. Analysis of genetic variation among strains of equine arteritis virus. In: Powell D.G., editor. Equine Infectious Diseases V. Proceedings of the Fifth International Conference. University Press of Kentucky; Lexington, KY: 1987. p. 3.
    33. Murphy TW, McCollum WH, Timoney PJ, Klingeborn BW, Hyllseth B, Golnik W, Erasmus B. Genomic variability among globally distributed isolates of equine arteritis virus.. Vet Microbiol 1992 Sep;32(2):101-15.
      pubmed: 1332249doi: 10.1016/0378-1135(92)90099-fgoogle scholar: lookup
    34. Neu S.M., Timoney P.J., Lowry S.R. Changes in semen quality following experimental equine arteritis virus infection in the stallion. Theriogenology. 1992;37:407.
    35. Neu S.M., Timoney P.J., McCollum W.H. Persistent infection of the reproductive tract in stallions experimentally infected with equine arteritis virus. In: Powell D.G., editor. Equine Infectious Diseases V: Proceedings of the Fifth International Conference. University Press of Kentucky; Lexington, KY: 1987. p. 149.
    36. Pottie A. The propagation of influenza from stallions to mares. J Comp Pathol Ther. 1888;1:37.
    37. Plagemann PG, Moennig V. Lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses.. Adv Virus Res 1992;41:99-192.
    38. Prickett ME, McCollum WH, Bryans JT: The gross and microscopic pathology observed in horses experimentally infected with equine arteritis virus. In Proceedings of the Third International Conference of Equine Diseases, Paris, 1972, p 265
    39. Pringle C.R. Committee pursues medley of virus taxonomic issues. Current Topics. ASM News. 1992;58:475.
    40. Timoney P.J., McCollum W.H. The epidemiology of equine viral arteritis. Proc AAEP. 1985;31:545.
    41. Timoney PJ, McCollum WH. Equine viral arteritis.. Can Vet J 1987 Nov;28(11):693-5.
      pmc: PMC1680490pubmed: 17422919
    42. Timoney P.J., McCollum W.H. Equine viral arteritis: Epidemiology and control. J Equine Vet Sci. 1988;8:54.
    43. Timoney P.J., McCollum W.H. Equine viral arteritis: Current clinical and economic significance. Proc AAEP. 1990;36:403.
    44. Timoney PJ, McCollum WH, Murphy TW, Roberts AW, Willard JG, Carswell GD. The carrier state in equine arteritis virus infection in the stallion with specific emphasis on the venereal mode of virus transmission.. J Reprod Fertil Suppl 1987;35:95-102.
      pubmed: 2824772
    45. Timoney PI, McCollum WH, Murphy TW: A longitudinal study of equine arteritis virus infection in Standardbred stallions with special reference to occurrence of the carrier state. In Equine Infectious Diseases VI: Proceedings of the Sixth International Conference, Cambridge, UK, 1991, p 231
    46. Timoney P.J., McCollum W.H., Roberts A.W. Detection of the carrier state in stallions persistently infected with equine arteritis virus. Proc AAEP. 1988;32:57.
    47. Timoney PJ, McCollum WH, Roberts AW, Murphy TW. Demonstration of the carrier state in naturally acquired equine arteritis virus infection in the stallion.. Res Vet Sci 1986 Sep;41(2):279-80.
      pubmed: 3022363
    48. Timoney PJ, McCollum WH, Roberts AW: Current strategies for the control of equine viral arteritis. In Proceedings of the 92nd Annual Meeting of the United States Animal Health Association, Little Rock, AR, 1988, p 211
    49. Timoney P.J., Umphenour N.W., McCollum W.H. Safety evaluation of a commercial live equine arteritis virus for use in stallions. In: Powell D.G., editor. Equine Infectious Diseases V. Proceedings of the Fifth International Conference. University Press of Kentucky; Lexington, KY: 1987. p. 19.
    50. Vaala WE, Hamir AN, Dubovi EJ, Timoney PJ, Ruiz B. Fatal, congenitally acquired infection with equine arteritis virus in a neonatal thoroughbred.. Equine Vet J 1992 Mar;24(2):155-8.
    51. Wensvoort G, Terpstra C, Pol JM, ter Laak EA, Bloemraad M, de Kluyver EP, Kragten C, van Buiten L, den Besten A, Wagenaar F. Mystery swine disease in The Netherlands: the isolation of Lelystad virus.. Vet Q 1991 Jul;13(3):121-30.
      pubmed: 1835211doi: 10.1080/01652176.1991.9694296google scholar: lookup
    52. Westaway EG, Brinton MA, Gaidamovich SYa, Horzinek MC, Igarashi A, Ku00e4u00e4riu00e4inen L, Lvov DK, Porterfield JS, Russell PK, Trent DW. Togaviridae.. Intervirology 1985;24(3):125-39.
      pubmed: 2999027doi: 10.1159/000149632google scholar: lookup

    Citations

    This article has been cited 53 times.
    1. Anderson C, Baha H, Boghdeh N, Barrera M, Alem F, Narayanan A. Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease.. Viruses 2023 May 13;15(5).
      doi: 10.3390/v15051163pubmed: 37243249google scholar: lookup
    2. Chen Q, Zhou J, Yang Z, Guo J, Liu Z, Sun X, Jiang Q, Fang L, Wang D, Xiao S. An intermolecular salt bridge linking substrate binding and P1 substrate specificity switch of arterivirus 3C-like proteases.. Comput Struct Biotechnol J 2022;20:3409-3421.
      doi: 10.1016/j.csbj.2022.06.059pubmed: 35832618google scholar: lookup
    3. Thieulent CJ, Carossino M, Balasuriya UBR, Graves K, Bailey E, Eberth J, Canisso IF, Andrews FM, Keowen ML, Go YY. Development of a TaqMan(u00ae) Allelic Discrimination qPCR Assay for Rapid Detection of Equine CXCL16 Allelic Variants Associated With the Establishment of Long-Term Equine Arteritis Virus Carrier State in Stallions.. Front Genet 2022;13:871875.
      doi: 10.3389/fgene.2022.871875pubmed: 35495124google scholar: lookup
    4. Knox A, Beddoe T. Isothermal Nucleic Acid Amplification Technologies for the Detection of Equine Viral Pathogens.. Animals (Basel) 2021 Jul 20;11(7).
      doi: 10.3390/ani11072150pubmed: 34359278google scholar: lookup
    5. Altan E, Li Y, Sabino-Santos G Jr, Sawaswong V, Barnum S, Pusterla N, Deng X, Delwart E. Viruses in Horses with Neurologic and Respiratory Diseases.. Viruses 2019 Oct 14;11(10).
      doi: 10.3390/v11100942pubmed: 31614994google scholar: lookup
    6. Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Cook RF, Timoney PJ, Balasuriya UBR. Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis.. PLoS Pathog 2019 Jul;15(7):e1007950.
      doi: 10.1371/journal.ppat.1007950pubmed: 31356622google scholar: lookup
    7. Nam B, Mekuria Z, Carossino M, Li G, Zheng Y, Zhang J, Cook RF, Shuck KM, Campos JR, Squires EL, Troedsson MHT, Timoney PJ, Balasuriya UBR. Intrahost Selection Pressure Drives Equine Arteritis Virus Evolution during Persistent Infection in the Stallion Reproductive Tract.. J Virol 2019 Jun 15;93(12).
      doi: 10.1128/JVI.00045-19pubmed: 30918077google scholar: lookup
    8. Bannai H, Nemoto M, Tsujimura K, Yamanaka T, Kokado H, Kondo T. Evaluation of two enzyme-linked immunosorbent assays for the detection of antibodies against equine arteritis virus.. J Equine Sci 2018 Dec;29(4):111-115.
      doi: 10.1294/jes.29.111pubmed: 30607135google scholar: lookup
    9. Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Shuck KM, Timoney PJ, Cook RF, Balasuriya UBR. Downregulation of MicroRNA eca-mir-128 in Seminal Exosomes and Enhanced Expression of CXCL16 in the Stallion Reproductive Tract Are Associated with Long-Term Persistence of Equine Arteritis Virus.. J Virol 2018 May 1;92(9).
      doi: 10.1128/JVI.00015-18pubmed: 29444949google scholar: lookup
    10. Laziu0107 S, Lupuloviu0107 D, Gaudaire D, Petrovic T, Laziu0107 G, Hans A. Serological evidence of equine arteritis virus infection and phylogenetic analysis of viral isolates in semen of stallions from Serbia.. BMC Vet Res 2017 Nov 7;13(1):316.
      doi: 10.1186/s12917-017-1226-xpubmed: 29115996google scholar: lookup
    11. Carossino M, Wagner B, Loynachan AT, Cook RF, Canisso IF, Chelvarajan L, Edwards CL, Nam B, Timoney JF, Timoney PJ, Balasuriya UBR. Equine Arteritis Virus Elicits a Mucosal Antibody Response in the Reproductive Tract of Persistently Infected Stallions.. Clin Vaccine Immunol 2017 Oct;24(10).
      doi: 10.1128/CVI.00215-17pubmed: 28814389google scholar: lookup
    12. Carossino M, Loynachan AT, Canisso IF, Cook RF, Campos JR, Nam B, Go YY, Squires EL, Troedsson MHT, Swerczek T, Del Piero F, Bailey E, Timoney PJ, Balasuriya UBR. Equine Arteritis Virus Has Specific Tropism for Stromal Cells and CD8(+) T and CD21(+) B Lymphocytes but Not for Glandular Epithelium at the Primary Site of Persistent Infection in the Stallion Reproductive Tract.. J Virol 2017 Jul 1;91(13).
      doi: 10.1128/JVI.00418-17pubmed: 28424285google scholar: lookup
    13. Sarkar S, Bailey E, Go YY, Cook RF, Kalbfleisch T, Eberth J, Chelvarajan RL, Shuck KM, Artiushin S, Timoney PJ, Balasuriya UB. Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion.. PLoS Genet 2016 Dec;12(12):e1006467.
      doi: 10.1371/journal.pgen.1006467pubmed: 27930647google scholar: lookup
    14. Sarkar S, Chelvarajan L, Go YY, Cook F, Artiushin S, Mondal S, Anderson K, Eberth J, Timoney PJ, Kalbfleisch TS, Bailey E, Balasuriya UB. Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor.. J Virol 2016 Jan 13;90(7):3366-84.
      doi: 10.1128/JVI.02455-15pubmed: 26764004google scholar: lookup
    15. Amat JP, Hendrikx P, Tapprest J, Leblond A, Dufour B. Comparative evaluation of three surveillance systems for infectious equine diseases in France and implications for future synergies.. Epidemiol Infect 2015 Oct;143(14):3122-33.
      doi: 10.1017/S0950268815000217pubmed: 25712325google scholar: lookup
    16. Steinbach F, Westcott DG, McGowan SL, Grierson SS, Frossard JP, Choudhury B. Re-emergence of a genetic outlier strain of equine arteritis virus: Impact on phylogeny.. Virus Res 2015 Apr 16;202:144-50.
    17. Scopel e Silva D, de Castro CC, da Silva e Silva F, Sant'anna V, Vargas GD, de Lima M, Fischer G, Brandelli A, da Motta Ade S, Hu00fcbner Sde O. Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals.. Braz J Microbiol 2014;45(3):1089-94.
    18. Hans A, Gaudaire D, Manuguerra JC, Leon A, Gessain A, Laugier C, Berthet N, Zientara S. Combination of an unbiased amplification method and a resequencing microarray for detecting and genotyping equine arteritis virus.. J Clin Microbiol 2015 Jan;53(1):287-91.
      doi: 10.1128/JCM.01935-14pubmed: 25339390google scholar: lookup
    19. Go YY, Li Y, Chen Z, Han M, Yoo D, Fang Y, Balasuriya UB. Equine arteritis virus does not induce interferon production in equine endothelial cells: identification of nonstructural protein 1 as a main interferon antagonist.. Biomed Res Int 2014;2014:420658.
      doi: 10.1155/2014/420658pubmed: 24967365google scholar: lookup
    20. Balasuriya UB, Zhang J, Go YY, MacLachlan NJ. Experiences with infectious cDNA clones of equine arteritis virus: lessons learned and insights gained.. Virology 2014 Aug;462-463:388-403.
      doi: 10.1016/j.virol.2014.04.029pubmed: 24913633google scholar: lookup
    21. Balasuriya UB, Go YY, MacLachlan NJ. Equine arteritis virus.. Vet Microbiol 2013 Nov 29;167(1-2):93-122.
      doi: 10.1016/j.vetmic.2013.06.015pubmed: 23891306google scholar: lookup
    22. Go YY, Bailey E, Timoney PJ, Shuck KM, Balasuriya UB. Evidence that in vitro susceptibility of CD3+ T lymphocytes to equine arteritis virus infection reflects genetic predisposition of naturally infected stallions to become carriers of the virus.. J Virol 2012 Nov;86(22):12407-10.
      doi: 10.1128/JVI.01698-12pubmed: 22933293google scholar: lookup
    23. Zhang J, Go YY, Huang CM, Meade BJ, Lu Z, Snijder EJ, Timoney PJ, Balasuriya UB. Development and characterization of an infectious cDNA clone of the modified live virus vaccine strain of equine arteritis virus.. Clin Vaccine Immunol 2012 Aug;19(8):1312-21.
      doi: 10.1128/CVI.00302-12pubmed: 22739697google scholar: lookup
    24. Go YY, Bailey E, Cook DG, Coleman SJ, Macleod JN, Chen KC, Timoney PJ, Balasuriya UB. Genome-wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection.. J Virol 2011 Dec;85(24):13174-84.
      doi: 10.1128/JVI.06068-11pubmed: 21994447google scholar: lookup
    25. Miszczak F, Shuck KM, Lu Z, Go YY, Zhang J, Sells S, Vabret A, Pronost S, Fortier G, Timoney PJ, Balasuriya UB. Evaluation of two magnetic-bead-based viral nucleic acid purification kits and three real-time reverse transcription-PCR reagent systems in two TaqMan assays for equine arteritis virus detection in semen.. J Clin Microbiol 2011 Oct;49(10):3694-6.
      doi: 10.1128/JCM.01187-11pubmed: 21832018google scholar: lookup
    26. Go YY, Snijder EJ, Timoney PJ, Balasuriya UB. Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus.. Clin Vaccine Immunol 2011 Feb;18(2):268-79.
      doi: 10.1128/CVI.00444-10pubmed: 21147938google scholar: lookup
    27. Gaudin C, Manolaridis I, Tucker PA, Conte MR. Resonance assignment of nsp7u03b1 from arterivirus.. Biomol NMR Assign 2011 Apr;5(1):23-5.
      doi: 10.1007/s12104-010-9258-1pubmed: 20703834google scholar: lookup
    28. Go YY, Zhang J, Timoney PJ, Cook RF, Horohov DW, Balasuriya UB. Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes.. J Virol 2010 May;84(10):4898-911.
      doi: 10.1128/JVI.02743-09pubmed: 20219931google scholar: lookup
    29. Zhang J, Stein DA, Timoney PJ, Balasuriya UB. Curing of HeLa cells persistently infected with equine arteritis virus by a peptide-conjugated morpholino oligomer.. Virus Res 2010 Jun;150(1-2):138-42.
    30. Zhang J, Timoney PJ, MacLachlan NJ, McCollum WH, Balasuriya UB. Persistent equine arteritis virus infection in HeLa cells.. J Virol 2008 Sep;82(17):8456-64.
      doi: 10.1128/JVI.01249-08pubmed: 18579588google scholar: lookup
    31. Go YY, Wong SJ, Branscum AJ, Demarest VL, Shuck KM, Vickers ML, Zhang J, McCollum WH, Timoney PJ, Balasuriya UB. Development of a fluorescent-microsphere immunoassay for detection of antibodies specific to equine arteritis virus and comparison with the virus neutralization test.. Clin Vaccine Immunol 2008 Jan;15(1):76-87.
      doi: 10.1128/CVI.00388-07pubmed: 18032597google scholar: lookup
    32. Echeverru00eda MG, Du00edaz S, Metz GE, Serena MS, Panei CJ, Nosetto E. Genetic typing of equine arteritis virus isolates from Argentina.. Virus Genes 2007 Oct;35(2):313-20.
      doi: 10.1007/s11262-007-0081-4pubmed: 17294142google scholar: lookup
    33. MacLachlan NJ, Balasuriya UB. Equine viral arteritis.. Adv Exp Med Biol 2006;581:429-33.
      doi: 10.1007/978-0-387-33012-9_77pubmed: 17037573google scholar: lookup
    34. Glaser AL, Chirnside ED, Horzinek MC, de Vries AA. Equine arteritis virus.. Theriogenology 1997 Apr 15;47(6):1275-95.
      doi: 10.1016/s0093-691x(97)00107-6pubmed: 16728076google scholar: lookup
    35. Wellenberg GJ, Stockhofe-Zurwieden N, Boersma WJ, De Jong MF, Elbers AR. The presence of co-infections in pigs with clinical signs of PMWS in The Netherlands: a case-control study.. Res Vet Sci 2004 Oct;77(2):177-84.
      doi: 10.1016/j.rvsc.2004.03.007pubmed: 15196908google scholar: lookup
    36. Castillo-Olivares J, Wieringa R, Bakonyi T, de Vries AA, Davis-Poynter NJ, Rottier PJ. Generation of a candidate live marker vaccine for equine arteritis virus by deletion of the major virus neutralization domain.. J Virol 2003 Aug;77(15):8470-80.
    37. Giese M, Bahr U, Jakob NJ, Kehm R, Handermann M, Mu00fcller H, Vahlenkamp TH, Spiess C, Schneider TH, Schusse G, Darai G. Stable and long-lasting immune response in horses after DNA vaccination against equine arteritis virus.. Virus Genes 2002 Oct;25(2):159-67.
      doi: 10.1023/a:1020109801925pubmed: 12418451google scholar: lookup
    38. Wieringa R, de Vries AA, Raamsman MJ, Rottier PJ. Characterization of two new structural glycoproteins, GP(3) and GP(4), of equine arteritis virus.. J Virol 2002 Nov;76(21):10829-40.
    39. Jeronimo C, Archambault D. Importance of M-protein C terminus as substrate antigen for serodetection of equine arteritis virus infection.. Clin Diagn Lab Immunol 2002 May;9(3):698-703.
      doi: 10.1128/cdli.9.3.698-703.2002pubmed: 11986280google scholar: lookup
    40. Hedges JF, Demaula CD, Moore BD, McLaughlin BE, Simon SI, MacLachlan NJ. Characterization of equine E-selectin.. Immunology 2001 Aug;103(4):498-504.
    41. Balasuriya UB, Heidner HW, Hedges JF, Williams JC, Davis NL, Johnston RE, MacLachlan NJ. Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles.. J Virol 2000 Nov;74(22):10623-30.
    42. Archambault D, St-Laurent G. Induction of apoptosis by equine arteritis virus infection.. Virus Genes 2000;20(2):143-7.
      doi: 10.1023/a:1008122715387pubmed: 10872876google scholar: lookup
    43. Weiland E, Bolz S, Weiland F, Herbst W, Raamsman MJ, Rottier PJ, De Vries AA. Monoclonal antibodies directed against conserved epitopes on the nucleocapsid protein and the major envelope glycoprotein of equine arteritis virus.. J Clin Microbiol 2000 Jun;38(6):2065-75.
    44. Hedges JF, Balasuriya UB, Timoney PJ, McCollum WH, MacLachlan NJ. Genetic divergence with emergence of novel phenotypic variants of equine arteritis virus during persistent infection of stallions.. J Virol 1999 May;73(5):3672-81.
    45. Brown CM, Timoney PJ. Getah virus infection of Indian horses.. Trop Anim Health Prod 1998 Aug;30(4):241-52.
      doi: 10.1023/a:1005079229232pubmed: 9760716google scholar: lookup
    46. Kheyar A, St-Laurent G, Diouri M, Archambault D. Nucleotide sequence and genetic analysis of the leader region of Canadian, American and European equine arteritis virus isolates.. Can J Vet Res 1998 Jul;62(3):224-30.
      pubmed: 9684053
    47. Kheyar A, Martin S, St-Laurent G, Timoney PJ, McCollum WH, Archambault D. Expression cloning and humoral immune response to the nucleocapsid and membrane proteins of equine arteritis virus.. Clin Diagn Lab Immunol 1997 Nov;4(6):648-52.
      doi: 10.1128/cdli.4.6.648-652.1997pubmed: 9384283google scholar: lookup
    48. Gilbert SA, Timoney PJ, McCollum WH, Deregt D. Detection of equine arteritis virus in the semen of carrier stallions by using a sensitive nested PCR assay.. J Clin Microbiol 1997 Aug;35(8):2181-3.
    49. Lepage N, St-Laurent G, Carman S, Archambault D. Comparison of nucleic and amino acid sequences and phylogenetic analysis of the Gs protein of various equine arteritis virus isolates.. Virus Genes 1996;13(1):87-91.
      doi: 10.1007/BF00576983pubmed: 8938984google scholar: lookup
    50. Kheyar A, St-Laurent G, Archambault D. Sequence determination of the extreme 5' end of equine arteritis virus leader region.. Virus Genes 1996;12(3):291-5.
      doi: 10.1007/BF00284650pubmed: 8883367google scholar: lookup
    51. Chen Z, Plagemann PG. Detection of related positive-strand RNA virus genomes by reverse transcription/polymerase chain reaction using degenerate primers for common replicase sequences.. Virus Res 1995 Dec;39(2-3):365-75.
      doi: 10.1016/0168-1702(95)00093-3pubmed: 8837898google scholar: lookup
    52. Hedges JF, Balasuriya UB, Timoney PJ, McCollum WH, MacLachlan NJ. Genetic variation in open reading frame 2 of field isolates and laboratory strains of equine arteritis virus.. Virus Res 1996 Jun;42(1-2):41-52.
      doi: 10.1016/0168-1702(96)01294-4pubmed: 8806173google scholar: lookup
    53. Anderson GW, Rowland RR, Palmer GA, Even C, Plagemann PG. Lactate dehydrogenase-elevating virus replication persists in liver, spleen, lymph node, and testis tissues and results in accumulation of viral RNA in germinal centers, concomitant with polyclonal activation of B cells.. J Virol 1995 Aug;69(8):5177-85.