Establishment of pregnancy after embryo transfer in mares with gonadal dysgenesis.
Abstract: Embryo transfer was performed in three mares with gonadal dysgenesis. Karyotypes of the mares were as follows: Mare 1, 63,XX, 64,XX, 65,XX; Mare 2, 63,X; and Mare 3, 65,XXX. The mares were administered progesterone in oil, 300 mg intramuscularly daily, starting 1 or 2 days after donor mare ovulation. Embryos were transferred on day 7 after donor ovulation. Mare 1 became pregnant after the first embryo transfer and had a normally developing fetus on necropsy on day 45 of gestation. Mare 3 became pregnant after the third embryo transfer, but the embryo was lost between day 14 and day 18 of gestation. Mare 2 received embryos on six occasions without maintaining pregnancy after transfer. Mares with gonadal dysgenesis treated with progesterone can establish and maintain pregnancy after embryo transfer, but there may be differences in this capability among mares, possibly related to the cause of the gonadal dysgenesis.
Publication Date: 1989-10-01 PubMed ID: 2632660DOI: 10.1007/BF01139187Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article discussed an experimental procedure in which pregnancy was attempted through embryo transfer in three mares suffering from gonadal dysgenesis. Despite some challenges, it was found that mares with this condition could potentially establish and maintain pregnancy with the help of progesterone treatment, although results varied between individual mares.
Overview of Research and Purpose
- The focus of the research was to understand whether mares suffering from gonadal dysgenesis, a condition characterised by abnormal development of gonads, could become and remain pregnant after embryo transfer.
- Through this study, the researchers sought to explore potential treatments and solutions for fertility issues in mares with this particular disorder.
Methodology Employed
- Three mares with gonadal dysgenesis were chosen for this study, each having different karyotypes (i.e., the number and appearance of chromosomes in the nucleus of a eukaryotic cell.)
- The mares were treated with 300mg of progesterone in oil intramuscularly daily, beginning 1 or 2 days after an ovulation event in a donor mare.
- The embryos were transferred to the mares on the seventh day following the ovulation of the donor mare.
Findings and Results
- Mare 1 was able to establish pregnancy after just the first embryo transfer, and a normal fetus development was found on day 45 of gestation during necropsy.
- Mare 3 managed to become pregnant after the third embryo transfer, although the embryo was lost between day 14 and day 18 of gestation.
- Despite six attempts, Mare 2 was unable to establish a pregnancy post-embryo transfer.
Conclusion and Implications
- Although there were variations in results, the research showed that mares with gonadal dysgenesis, when treated with progesterone, have the potential to establish and maintain a pregnancy following an embryo transfer.
- However, the variation in results among the mares suggests that the ability to maintain a pregnancy could be associated with the specific cause of gonadal dysgenesis. This implies that further research is needed to understand the exact influence of gonadal dysgenesis on mare fertility.
Cite This Article
APA
Hinrichs K, Riera FL, Klunder LR.
(1989).
Establishment of pregnancy after embryo transfer in mares with gonadal dysgenesis.
J In Vitro Fert Embryo Transf, 6(5), 305-309.
https://doi.org/10.1007/BF01139187 Publication
Researcher Affiliations
- Section of Reproductive Studies, University of Pennsylvania School of Veterinary Medicine, Kennett Square 19348.
MeSH Terms
- Animals
- Embryo Transfer
- Endometrium / cytology
- Female
- Gonadal Dysgenesis / veterinary
- Horse Diseases / therapy
- Horses
- Infertility, Female / therapy
- Infertility, Female / veterinary
- Pregnancy
- Pregnancy, Animal / drug effects
- Progesterone / therapeutic use
- Uterus / drug effects
References
This article includes 10 references
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- N Engl J Med. 1986 Mar 27;314(13):806-11
- J Reprod Fertil. 1987 Jul;80(2):395-401
- J Am Vet Med Assoc. 1981 Nov 15;179(10):987-91
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- J Reprod Fertil Suppl. 1982;32:459-64
- J Reprod Fertil. 1987 Mar;79(2):531-7
- Am J Med Genet. 1980;5(4):339-43
- Hereditas. 1980;92(1):145-62
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