Evaluating continuous blood coagulopathy in assessing the severity of acute colitis in Thoroughbred racehorses.
Abstract: Although severe blood coagulopathy in horses with acute colitis causes multiple organ failure, which may be fatal, few studies have focused on the correlation between the fluctuations of coagulation parameters and severity of colitis. In this study, we evaluated the fluctuations of coagulation parameters in 14 Thoroughbred racehorses with acute colitis for 5 days from the day of hospitalization and compared them between 5 survivors and 9 non-survivors. Noteworthy features in the non-survivors were that antithrombin activity and fibrin degradation products continuously decreased and increased, respectively, for 4 days or more and that thrombin-antithrombin complexes increased in the last 2 days before death. Thus, these parameters should be continuously monitored to observe these fluctuations in assessing the severity of acute colitis.
Publication Date: 2018-09-19 PubMed ID: 30250396PubMed Central: PMC6145864DOI: 10.1294/jes.29.79Google Scholar: Lookup
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- Journal Article
Summary
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This study examines the relationship between changes in the blood coagulation process and the severity of acute colitis in Thoroughbred racehorses, and suggests that continuous monitoring of these parameters could help assess severity levels of colitis in horses.
Introduction
- Colitis is a severe disease affecting the colon of horses and can prove fatal, especially when accompanied by severe blood coagulopathy – the process through which your body forms blood clots.
- Critical conditions like acute colitis lead to multiple organ failure if not met with appropriate actions in time. While this fact is well recorded, scant attention has been given to the correlation between coagulation parameters’ fluctuations and the severity of the disease.
Objective
- The objective of this research paper is to examine fluctuations in coagulation parameters in Thoroughbred racehorses with acute colitis over a span of 5 days from the day of hospitalization.
- This evaluation is done by comparing the parameters between two sets of these horses: the survivors and the non-survivors.
Methodology
- The study involved a total of 14 Thoroughbred racehorses struck by acute colitis. Out of these, 5 horses survived the condition while 9 did not.
- The coagulation parameters of these horses were closely monitored for 5 days, from the day they were hospitalized.
Findings and Implications
- The important findings highlight that in the non-survivors, the antithrombin activity (antithrombin prevents excessive blood clotting) progressively decreased while the fibrin degradation products (fibrin is the protein that forms blood clots) kept increasing for 4 days or more.
- Simultaneously, the non-survivors also demonstrated an increase in thrombin-antithrombin complexes in the last 2 days before death. The thrombin-antithrombin complex is important in regulating coagulation.
- The findings, thus, suggest that these parameters should be continuously monitored to observe their fluctuations. This monitoring can play a crucial role in assessing the severity of acute colitis in horses, which can further inform the prognosis and possible treatment strategies.
Cite This Article
APA
Nomura M, Mizobe F, Kato T, Kuroda T, Urayama S, Muranaka M.
(2018).
Evaluating continuous blood coagulopathy in assessing the severity of acute colitis in Thoroughbred racehorses.
J Equine Sci, 29(3), 79-85.
https://doi.org/10.1294/jes.29.79 Publication
Researcher Affiliations
- Racehorse Clinic, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Clinic, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Clinic, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Racehorse Clinic, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
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