Evaluation of a new handheld point-of-care blood gas analyser using 100 equine blood samples.
Abstract: To determine whether the Enterprise point-of-care blood analysis system (EPOC) produces results in agreement with two other blood gas analysers in regular clinical use (i-STAT and Radiometer ABL77) and to investigate the precision of the new machine when used with equine whole blood. Prospective, randomized, non-blinded, comparative laboratory analyser study. Horses admitted to a university teaching hospital requiring arterial or venous blood gas analysis as part of their routine clinical management. One hundred equine blood samples were run immediately, consecutively and in randomized order on three blood gas analysers. Results of variables common to all three analysers were tested for agreement and compared with guidelines used in human medicine. These require 80% of results from the test analyser to fall within a defined range or percentage of results from the comparator devices to achieve acceptability. Additionally, 21 samples were run twice in quick succession on the EPOC analyser to investigate precision. Agreement targets were not met for haematocrit, haemoglobin and base excess for either i-STAT or ABL77 analysers. EPOC precision targets were not met for partial pressure of carbon dioxide, ionized calcium, haematocrit and haemoglobin. Overall comparative performance of the EPOC was good to excellent for pH, oxygen tension, potassium, bicarbonate and oxygen saturation of haemoglobin, but marginal to poor for other parameters. The EPOC may be useful in performing analysis of equine whole blood, but trend analysis of carbon dioxide tension, ionized calcium, haematocrit and haemoglobin should be interpreted with caution. The EPOC should not be used interchangeably with other blood gas analysers.
Copyright © 2016 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2017-02-22 PubMed ID: 28237685DOI: 10.1111/vaa.12392Google Scholar: Lookup
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- Journal Article
Summary
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The research paper is about an assessment of a new handheld device for blood gas analysis in horses, comparing its precision and compatibility with two other regular clinical instruments.
Objective of the Study
- The paper discusses a study carried out to evaluate the performance of a new handheld point-of-care (POC) blood gas analyzer known as Enterprise (EPOC). Its effectiveness was compared with two other blood gas analyzers – i-STAT and Radiometer ABL77 – frequently used in clinical settings on equine blood.
Methodology
- For this comparative laboratory analyzer study, 100 blood samples obtained from horses admitted to a university teaching hospital were utilized.
- The samples were analyzed immediately and in a randomized manner using the three distinct blood gas analyzers.
- Then, the results were evaluated based on predefined standards borrowed from human medicine for agreement. To be deemed acceptable, 80% of the EPOC results had to fall within a specified range or percentage of the findings from the comparator devices–i-STAT and ABL77.
- In addition to this, 21 samples were tested twice consecutively on the EPOC analyzer to scrutinize its precision.
Findings
- The results showed that EPOC did not meet the agreement criteria for haematocrit, haemoglobin and base excess when compared to both the i-STAT and ABL77 analysers.
- When it came to precision, the EPOC missed the target for partial pressure of carbon dioxide, ionized calcium, haematocrit and haemoglobin.
- However, the device displayed good to excellent comparative performance for pH, oxygen tension, potassium, bicarbonate, and oxygen saturation of haemoglobin.
- For certain parameters, the performance was unfortunately marginal to poor.
Conclusion
- The study concluded that, although the EPOC analyser may be efficient in analyzing equine whole blood, the results for carbon dioxide tension, ionized calcium, haematocrit, and haemoglobin should be interpreted cautiously.
- Based on their results, the researchers advised against using the EPOC interchangeably with other blood gas analysers.
Cite This Article
APA
Bardell D, West E, Mark Senior J.
(2017).
Evaluation of a new handheld point-of-care blood gas analyser using 100 equine blood samples.
Vet Anaesth Analg, 44(1), 77-85.
https://doi.org/10.1111/vaa.12392 Publication
Researcher Affiliations
- School of Veterinary Science, Leahurst Campus, University of Liverpool, Neston, UK. Electronic address: david.bardell@liverpool.ac.uk.
- School of Veterinary Science, Leahurst Campus, University of Liverpool, Neston, UK.
- School of Veterinary Science, Leahurst Campus, University of Liverpool, Neston, UK.
Citations
This article has been cited 5 times.- Sandersen C, Dmitrovic P, Dupont J, Cesarini C, Guyot H, Serteyn D, Kirsch K. Analytical Performance Evaluation of the New GEM(®) Premier™ 5000 in Comparison to the Epoc(®) Blood Gas Analyzer in Horses.. Vet Sci 2023 Feb 3;10(2).
- Steyrer C, Pohlin F, Meyer LCR, Buss P, Hooijberg EH. Comparison of three hematocrit measurement methods in the southern white rhinoceros (Ceratotherium simum simum).. Vet Clin Pathol 2022 Jun;51(2):225-230.
- Lee SH, Choi EW, Kim D. Relationship between the values of blood parameters and physical status in Korean native calves with diarrhea.. J Vet Sci 2020 Mar;21(2):e17.
- Xu L, Chockalingam A, Stewart S, Shea K, Matta MK, Narayanasamy S, Pilli NR, Volpe DA, Weaver J, Zhu H, Davis MC, Rouse R. Developing an animal model to detect drug-drug interactions impacting drug-induced respiratory depression.. Toxicol Rep 2020;7:188-197.
- Kirsch K, Sandersen C. Traditional and quantitative analysis of acid-base and electrolyte imbalances in horses competing in cross-country competitions at 2-star to 5-star level.. J Vet Intern Med 2020 Mar;34(2):909-921.
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