Evaluation of acetaminophen absorption in horses with experimentally induced delayed gastric emptying.
Abstract: To evaluate the correlation between the half-time of liquid-phase gastric emptying (T50) determined by use of nuclear scintigraphy, using technetiumTc 99m pentetate, and absorption variables of orally administered acetaminophen in horses with experimentally delayed gastric emptying. Methods: 6 mature horses. Methods: Delayed gastric emptying was induced by IV injection of atropine sulfate. Twenty minutes later, acetaminophen and technetium Tc 99m pentetate were administered simultaneously via nasogastric tube. Serial lateral images of the stomach region were obtained, using a gamma camera. Power exponential curves were used for estimation of T50 and modified R2 values for estimation of goodness-of-fit of the data. Serial serum samples were obtained, and acetaminophen concentration was determined, using fluorescence polarization immunoassay. Maximum serum concentration (Cmax), time to reach maximum serum concentration (Tmax), area under the curve for 480 minutes, and the appearance rate constant were determined, using a parameter estimation program. Correlations were calculated, using a Spearman rank correlation coefficient. Results: A significant correlation was detected between T50 determined by use of scintigraphy and Tmax determined by use of acetaminophen absorption. Correlation between T50 and other absorption variables of acetaminophen was not significant. Conclusions: The acetaminophen absorption method was a valid technique in this model of delayed gastric emptying in horses. The method may be a valuable tool for use in research as well as in clinical evaluation of gastric emptying in horses.
Publication Date: 2002-02-15 PubMed ID: 11843113DOI: 10.2460/ajvr.2002.63.170Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research explores the relationship between gastric emptying time (T50) and acetaminophen absorption in horses with experimentally delayed gastric emptying, through a series of scientific techniques and observations. The results show a significant correlation between the T50 and the time it takes for maximum acetaminophen concentration in the blood (Tmax).
Research Methodology
- The subjects of this study were six mature horses whose gastric emptying was intentionally delayed through intravenous injection of atropine sulfate.
- Twenty minutes following the injection, acetaminophen and technetium Tc 99m pentetate, a radioactive tracer, were orally administered to the horses through a nasogastric tube.
- Using a gamma camera, serial lateral images of the stomach region were captured and used to estimate the half-time of liquid-phase gastric emptying (T50) using power exponential curves.
- Samples of the horses’ serum were serially obtained to determine acetaminophen concentration using fluorescence polarization immunoassay.
- The maximum serum concentration (Cmax), time to reach maximum serum concentration (Tmax), area under the curve for 480 minutes, and the appearance rate constant were computed using a parameter estimation program.
- Correlations were calculated using a Spearman rank correlation coefficient.
Research Findings
- The study found a significant correlation between T50 determined by nuclear scintigraphy and Tmax ascertained through acetaminophen absorption.
- No significant correlation was found between T50 and other acetaminophen absorption variables.
Implications
- The study concludes by validating the acetaminophen absorption method in studying delayed gastric emptying in horses.
- This methodology could be a valuable tool for future research and clinical evaluations of gastric emptying in horses.
Cite This Article
APA
Lohmann KL, Bahr A, Cohen ND, Boothe DM, Roussel AJ.
(2002).
Evaluation of acetaminophen absorption in horses with experimentally induced delayed gastric emptying.
Am J Vet Res, 63(2), 170-174.
https://doi.org/10.2460/ajvr.2002.63.170 Publication
Researcher Affiliations
- Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475, USA.
MeSH Terms
- Absorption
- Acetaminophen / administration & dosage
- Acetaminophen / pharmacokinetics
- Administration, Oral
- Animals
- Gastric Emptying / physiology
- Half-Life
- Horses / metabolism
- Radionuclide Imaging / veterinary
- Radiopharmaceuticals
- Stomach / diagnostic imaging
- Technetium Tc 99m Pentetate
Citations
This article has been cited 2 times.- Gold JR, Grubb T, Court MH, Villarino NF. Pharmacokinetics of acetaminophen after a single Oral administration of 20 or 40 mg/kg to 7-9 Day-old foals. Front Vet Sci 2023;10:1198940.
- Albarazanji K, Nawrocki AR, Gao B, Wang X, Wang YJ, Xiao YF. Effects of mixed meal tolerance test on gastric emptying, glucose and lipid homeostasis in obese nonhuman primates. Sci Rep 2021 Jun 4;11(1):11866.
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