Evaluation of adenosine deaminase and other purine salvage pathway enzymes in horses with combined immunodeficiency.
Abstract: Foals with combined immunodeficiency had normal levels of purine salvage pathway enzymes, including adenosine deaminase, nucleoside phosphorylase, and xanthine oxidase.
Publication Date: 1976-03-01 PubMed ID: 818021PubMed Central: PMC420706DOI: 10.1128/iai.13.3.995-997.1976Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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This research article investigates the levels of purine salvage pathway enzymes, including adenosine deaminase, in foals with combined immunodeficiency, showing that these levels were normal.
Research Overview
To summarize the study:
- The focus of the research is on the examination of purine salvage pathway enzymes, specifically adenosine deaminase, in foals (young horses) with combined immunodeficiency.
- Combined immunodeficiency is a disorder where components of the immune system are absent or poorly functioning, leading to increased vulnerability to infection.
- Adenosine deaminase and similar enzymes are part of the purine salvage pathway, which plays a significant role in DNA synthesis, cellular activity, and therefore immune function.
- Foals with combined immunodeficiency had normal levels of these enzymes according to the findings of this research.
Research Methodology
- Enzyme levels in foals with combined immunodeficiency were likely measured using specific lab testing procedures, although the exact methods are not specified in the abstract.
- These methods would generally involve taking biological samples from the foals and analyzing them in a lab for levels of the specified enzymes.
- The foals’ levels were likely compared to “normal” levels found in healthy foals in order to determine if there was a significant difference.
Findings and Conclusions
- The research found that foals with combined immunodeficiency had normal levels of purine salvage pathway enzymes, including adenosine deaminase.
- This finding indicates that these enzymes are likely not the root cause of the immune deficiencies seen in these foals.
- However, while the functions of these enzymes may be normal, their activities in the cells could potentially be impacting how the immune system functions in ways that aren’t measured by simply looking at enzyme levels.
- Further research would be needed to explore these possibilities and to further understand the complex relationships between these enzymes and the immune system.
Cite This Article
APA
McGuire TC, Pollara B, Moore JJ, Poppie MJ.
(1976).
Evaluation of adenosine deaminase and other purine salvage pathway enzymes in horses with combined immunodeficiency.
Infect Immun, 13(3), 995-997.
https://doi.org/10.1128/iai.13.3.995-997.1976 Publication
Researcher Affiliations
MeSH Terms
- Adenosine Deaminase / analysis
- Animals
- Female
- Horses
- Immunologic Deficiency Syndromes / enzymology
- Male
- Nucleoside Deaminases / analysis
- Purine-Nucleoside Phosphorylase / analysis
- Xanthine Oxidase / analysis
References
This article includes 12 references
- BRADY TG, O'DONOVAN CI. A STUDY OF THE TISSUE DISTRIBUTION OF ADENOSINE DEAMINASE IN SIX MAMMAL SPECIES.. Comp Biochem Physiol 1965 Jan;14:101-20.
- Giblett ER, Anderson JE, Cohen F, Pollara B, Meuwissen HJ. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.. Lancet 1972 Nov 18;2(7786):1067-9.
- Pickering RJ, Pollara B, Meuwissen HJ. Workshop on severe combined immunological deficiency disease and adenosine deaminase deficiency. Albany, New York, on October 1, 1973.. Clin Immunol Immunopathol 1974 Nov;3(2):301-3.
- Bartholomew WR, Provost TT. Letter: Combined-immunodeficiency disease with normal erythrocyte A.D.A.. Lancet 1974 Apr;1(7859):678.
- Creagan RP, Tischfield JA, Nichols EA, Ruddle FH. Letter: Autosomal assignment of the gene for the form of adenosine deaminase which is deficient in patients with combined immunodeficiency syndrome.. Lancet 1973 Dec 22;2(7843):1449.
- Andrews P. Estimation of the molecular weights of proteins by Sephadex gel-filtration.. Biochem J 1964 May;91(2):222-33.
- McGuire TC, Poppie MJ, Banks KL. Combined (B- and T-lymphocyte) immunodeficiency: a fatal genetic disease in Arabian foals.. J Am Vet Med Assoc 1974 Jan 1;164(1):70-6.
- McGuire TC, Poppie MJ. Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder.. Infect Immun 1973 Aug;8(2):272-7.
- Scott CR, Chen SH, Giblett ER. Detection of the carrier state in combined immunodeficiency disease associated with adenosine deaminase deficiency.. J Clin Invest 1974 Apr;53(4):1194-6.
- McGuire TC, Banks KL, Poppie MJ. Combined immunodeficiency in horses: characterization of the lymphocyte defect.. Clin Immunol Immunopathol 1975 Mar;3(4):555-66.
- Parkman R, Gelfand EW, Rosen FS, Sanderson A, Hirschhorn R. Severe combined immunodeficiency and adenosine deaminase deficiency.. N Engl J Med 1975 Apr 3;292(14):714-9.
- Hopkinson DA, Cook PJ, Harris H. Further data on the adenosine deaminase (ADA) polymprphism and a report of a new phenotype.. Ann Hum Genet 1969 May;32(4):361-7.
Citations
This article has been cited 5 times.- Rodríguez-Sánchez IP, Treviño-Alvarado VM, Torres-Sepúlveda Mdel R, López-Saldaña LA, Ponce-García G, López-Uriarte GA, Ruiz-Herrera Mdel C, Zamora-Ávila DE, Villarreal-Pérez JZ, Dávalos-Aranda G, Martínez-de-Villarreal LE. Reference values for amino acids and acylcarnitines in peripheral blood in Quarter horses and American Miniature horses.. Acta Vet Scand 2015 Sep 29;57:62.
- Al-Safi SA, Maddocks JL. Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.. Br J Clin Pharmacol 1984 Apr;17(4):417-22.
- Adams A, Harkness RA. Adenosine deaminase activity in thymus and other human tissues.. Clin Exp Immunol 1976 Dec;26(3):647-9.
- McGuire TC, Banks KL, Davis WC. Alterations of the thymus and other lymphoid tissue in young horses with combined immunodeficiency.. Am J Pathol 1976 Jul;84(1):39-54.
- Magnuson NS, Perryman LE. In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency.. J Clin Invest 1979 Jul;64(1):89-101.
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