Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses.
Abstract: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses. Methods: 9 healthy adult horses. Methods: Each horse received 4 treatments in a blinded, randomized, crossover study design as follows: TMS, 16 to 24 mg/kg, IV; DET, 0.015 to 0.02 mg/kg, IV; TMS plus DET; and saline (0.9% NaCl) solution. Surface ECG traces were obtained over 24 hours, and repolarization parameters were measured at predefined time points after each treatment and compared with a 2-way ANOVA for repeated measures. Results: Heart rate-corrected QT intervals (QTc) were significantly increased after administration of DET (mean ± SD difference in QTc, 36.57 ± 23.07 milliseconds; increase of 7%) and TMS plus DET (44.96 ± 29.16 milliseconds; increase of 9%), compared with baseline (before treatment) values and values after administration of saline solution. Saline solution and TMS alone did not affect QTc. Conclusions: Administration of DET or TMS plus DET was associated with a significant and possibly clinically relevant prolongation of QTc, with prolongation of 7% to 9%, a range that is considered as a risk factor for the development of cardiac arrhythmias in people. Results were unexpected because DET is considered to be a safe sedative for horses.
Publication Date: 2021-02-26 PubMed ID: 33629897DOI: 10.2460/ajvr.82.3.207Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Veterinary
- Adult Horses
- Cardiac Arrhythmias
- Cardiovascular Health
- Clinical Examination
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Detomidine
- Diagnosis
- Disease Diagnosis
- Disease Treatment
- Electrocardiography
- Equine Health
- Heart Rate
- Horses
- Pharmacodynamics
- Pharmacology
- Veterinary Medicine
- Veterinary Procedure
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study examined how trimethoprim-sulfadiazine (TMS), detomidine (DET), or a combination of both affect the ECG repolarization parameters in horses.
Objective and Methodology
- The purpose of this research was to analyze any changes in Horse ECG repolarization parameters after administering trimethoprim-sulfadiazine (TMS), detomidine (DET), or a combination of both.
- The study made use of nine healthy adult horses. The study design was a blinded, randomized, crossover trial and each horse received four different treatments which were TMS, DET, a combination of TMS and DET, and saline (0.9% NaCl) solution.
- The dosage of TMS was between 16 to 24 mg/kg and DET 0.015 to 0.02 mg/kg, both administered intravenously. The combination dosage was not specific.
- ECG traces were obtained for the duration of 24 hours and the repolarization parameters observed at predefined times post each treatment. These were later compared using a two-way ANOVA for repeated measures.
Results and Conclusions
- The results indicated a significant increase in the heart rate-corrected QT intervals (QTc) after DET or DET with TMS administration compared to baseline and saline-treated values.
- When DET was administered, the QTc increased by 7% (average deviation of 36.57 ± 23.07 milliseconds) whereas it increased by 9% (average deviation of 44.96 ± 29.16 milliseconds) when both medications were administered together.
- The results didn’t indicate significant changes in QTc values after the administration of saline solution or TMS alone.
- The findings imply that DET or a combination of DET and TMS resulted in a significant, potentially clinically relevant, prolongation of QTc. The degree of elongation ranges between 7% to 9%, a range considered a risk factor for the potential development of cardiac arrhythmias in humans.
- The results were unexpected as DET is considered generally safe to use for sedation in horses.
Cite This Article
APA
Trachsel DS, Calloe K, J Rgensen E, Lunddahl CS, Pedersen PJ, Kanters JRK, Klaerke DA, Buhl R.
(2021).
Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses.
Am J Vet Res, 82(3), 207-217.
https://doi.org/10.2460/ajvr.82.3.207 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cross-Over Studies
- Electrocardiography / veterinary
- Heart Rate
- Horses
- Imidazoles
- Sulfadiazine
- Trimethoprim / adverse effects
Citations
This article has been cited 1 times.- Hobbs K, Luethy D, Davis J, Mallicote M, Torcivia C, Kulp J, Stefanovski D, Futterman C, Cooper F, van Eps A. The effects of orally administered trazodone on ambulation and recumbency in healthy horses.. J Vet Intern Med 2023 Sep-Oct;37(5):1899-1906.
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