Evaluation of laser Doppler flowmetry for measuring coronary band and laminar microcirculatory blood flow in clinically normal horses.
Abstract: Once daily for 3 days, laser Doppler flowmetry was used in 5 healthy, nonsedated adult horses to evaluate coronary band and laminar microcirculatory blood flow (MBF) in both forelimbs. The coronary band had significantly (P < 0.05) higher MBF than did the laminae on the days evaluated. Significant variation in MBF was not found over the 3-day measurement period in any one site. Significant (P < 0.05) variation was found in coronary band MBF among horses. This variation was not observed in laminar MBF. On occlusion of the digital arteries at the level of the fetlock, marked decrease in coronary band and laminar MBF was observed. Twenty minutes after IV administration of acetylpromazine, marked increase in coronary band and laminar MBF was observed. The technique was easily performed in standing nonsedated horses, did not inflict discomfort, lacked complications, and measurements were repeatable. This technique provides an index of digital MBF, either intermittently or continuously, avoiding introduction of invasive variables associated with other techniques.
Publication Date: 1994-04-01 PubMed ID: 8017686
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research used laser Doppler flowmetry to study the microcirculatory blood flow in the coronary band and laminar of healthy horses and monitor the changes under different conditions. The method was found to be easy to administer with repeatable results, offering an effective way to continuously measure blood flow without the need for invasive procedures.
Methodology
- The study was performed on five healthy adult horses which were not sedated.
- Laser Doppler flowmetry was used once a day over three days to measure the microcirculatory blood flow (MBF) in the coronary band and laminae of both forelimbs of the horses.
- Measurements were taken both before and after occluding the digital arteries at the fetlock level and post intravenous administration of acetylpromazine, to monitor any changes in MBF due to these conditions.
Findings
- Under regular conditions, the coronary band had significantly higher MBF than the laminae on all three days. There was no significant variation observed in MBF over the three-day period for any singular site.
- Significant variation was found in MBF among different horses for the coronary band, but not for the laminar MBF.
- When the digital arteries were occluded, there was a marked decrease in both coronary band and laminar MBF. Conversely, a marked increase in both coronary band and laminar MBF was observed twenty minutes after intravenous administration of acetylpromazine.
Significance
- The use of laser Doppler flowmetry allowed for an easy and repeatable measurement process that does not cause discomfort or complications for the equine subjects.
- This technique provides a reliable index of digital MBF, either intermittently or continuously, negating the need for more invasive measurement techniques.
- The variability of the coronary band MBF among horses suggests the potential for individualized baseline measurements for this site, while the laminar MBF appeared to be consistent.
Cite This Article
APA
Adair HS, Goble DO, Shires GM, Sanders WL.
(1994).
Evaluation of laser Doppler flowmetry for measuring coronary band and laminar microcirculatory blood flow in clinically normal horses.
Am J Vet Res, 55(4), 445-449.
Publication
Researcher Affiliations
- Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
MeSH Terms
- Acepromazine / pharmacology
- Animals
- Blood Flow Velocity / drug effects
- Coronary Circulation / drug effects
- Evaluation Studies as Topic
- Horses / physiology
- Laser-Doppler Flowmetry / veterinary
- Microcirculation / drug effects
- Reference Values
Citations
This article has been cited 2 times.- Pequito M, Amory H, de Moffarts B, Busoni V, Serteyn D, Sandersen C. Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses. Can Vet J 2013 Feb;54(2):150-6.
- Bergh A, Nyman G, Lundeberg T, Drevemo S. Effect of defocused CO2 laser on equine tissue perfusion. Acta Vet Scand 2006;47(1):33-42.
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