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Home / Equine Research Bank / Equine Vet J / Evaluation of peritoneal fluid lactate as a marker of intest...
Equine veterinary journal2005; 37(4); 342-346; doi: 10.2746/0425164054529319

Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic.

Abstract: The most common cause of death as a direct result of colic is acute circulatory failure secondary to intestinal ischaemia. Early and accurate recognition of ischaemic bowel is essential to decrease complications and increase survival. Blood to peritoneal lactate values have been evaluated as a prognostic indicator, but lactate values characterised by type of lesion have not been reported. Objective: Plasma and peritoneal lactate values are higher in horses with intestinal ischaemia secondary to a strangulating obstruction (ISSO). Methods: Venous blood and peritoneal fluid were collected sequentially from 20 clinically healthy horses and 189 horses admitted for colic during a one-year period. Blood gas, pH, electrolyte (K+, Na+, Ca++, Cl-), glucose and lactate values were determined for blood and peritoneal fluid samples; other values recorded for peritoneal fluid included gross appearance, total protein and nucleated cell count. Information regarding diagnosis, treatment and outcome was retrieved from the medical records. Results: Peritoneal and plasma levels of lactate were lower in control compared to clinical cases. Horses with ISSO had a higher peritoneal lactate value (8.45 mmol/l) than those with nonstrangulating obstruction (2.09 mmo/l). Factors with the strongest correlations with the presence of ISSO were changes in the gross appearance of the peritoneal fluid and values of peritoneal fluid chloride, pH and log10 lactate. Conclusions: Analysis of peritoneal fluid gross appearance, pH, lactate and chloride can be used for diagnosis of ISSO. Conclusions: Peritoneal fluid lactate is a better predictor of ISSO than blood lactate and may aid in early detection of catastrophic peritoneal lesions such as intestinal strangulation and rupture.
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Publication Date: 2005-07-21 PubMed ID: 16028624DOI: 10.2746/0425164054529319Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the use of peritoneal fluid lactate as an indicator of intestinal ischaemia in equine colic. It found that peritoneal fluid lactate was a more reliable indicator of serious intestinal problems in horses than previous methods.

Study Objective

  • The article aimed to understand if there was a correlation between the plasma and peritoneal lactate values and intestinal ischaemia, which is caused by strangulating obstruction (ISSO).
  • Early detection of ischaemic bowel is critical to reducing complications and improving survival rates for equines suffering from colic, and the researchers sought to identify a more accurate method of diagnosis.

Methodology

  • Over a one-year period, the researchers collected venous blood and peritoneal fluid sequentially from 20 clinically healthy horses and 189 horses admitted for colic.
  • Blood gas, pH, electrolyte (K+, Na+, Ca++, Cl-), glucose, lactate values and other values for peritoneal fluids like gross appearance, total protein and nucleated cell count were recorded.
  • Details regarding diagnoses, treatment and outcome were gathered from medical records for analysis.

Results

  • Compared to healthy horses, the clinical cases had higher levels of lactate in their plasma and peritoneal fluid.
  • Horses with ISSO had higher peritoneal lactate values (8.45 mmol/l) compared to those experiencing a non-strangulating obstruction (2.09 mmol/l).
  • The study identified several factors strongly correlated with the presence of ISSO, including changes in the peritoneal fluid’s gross appearance, peritoneal fluid chloride, and pH and log10 lactate values.

Conclusions

  • The researchers concluded that analyzing peritoneal fluid’s gross appearance, pH, lactate, and chloride levels could help diagnose ISSO in horses suffering from colic.
  • The study also found that peritoneal fluid lactate levels are a better predictor for ISSO compared to blood lactate levels, suggesting that this could aid in the early detection of grave peritoneal anomalies like intestinal strangulation and rupture.

Cite This Article

APA
Latson KM, Nieto JE, Beldomenico PM, Snyder JR. (2005). Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic. Equine Vet J, 37(4), 342-346. https://doi.org/10.2746/0425164054529319

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 37
Issue: 4
Pages: 342-346

Researcher Affiliations

Latson, K M
  • Veterinary Medical Teaching Hospital and Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, USA.
Nieto, J E
    Beldomenico, P M
      Snyder, J R

        MeSH Terms

        • Animals
        • Ascitic Fluid / chemistry
        • Biomarkers / analysis
        • Biomarkers / blood
        • Blood Gas Analysis / veterinary
        • Case-Control Studies
        • Chlorides / analysis
        • Colic / diagnosis
        • Colic / metabolism
        • Colic / veterinary
        • Female
        • Horse Diseases / blood
        • Horse Diseases / diagnosis
        • Horse Diseases / metabolism
        • Horses
        • Intestinal Obstruction / diagnosis
        • Intestinal Obstruction / metabolism
        • Intestinal Obstruction / veterinary
        • Intestines / blood supply
        • Ischemia / diagnosis
        • Ischemia / metabolism
        • Ischemia / veterinary
        • Lactates / analysis
        • Lactates / blood
        • Male

        Citations

        This article has been cited 21 times.
        1. Nocera I, Cingottini D, Di Franco C, Sala G, Bindi F, Spadari A, Rinnovati R, Vitale V, Jose-Cunilleras E, Sgorbini M. In-Depth Analysis of the Prognostic Factors Associated with Short-Term Outcome in Equine Colic Patients: Multicentric Retrospective Study. Animals (Basel) 2026 Feb 5;16(3).
          doi: 10.3390/ani16030496pubmed: 41681477google scholar: lookup
        2. Mirzaei A, Hajimohammadi A. Diagnostic performance of specific oxidative stress biomarkers, acute phase proteins, and certain trace elements in different severities of equine colic. J Equine Sci 2025 Jun;36(2):45-54.
          doi: 10.1294/jes.36.45pubmed: 40832000google scholar: lookup
        3. Bishop RC, Arrington JV, Wilkins PA, McCoy AM. Alterations in the Peritoneal Fluid Proteome of Horses with Colic Attributed to Ischemic and Non-Ischemic Intestinal Disease. Animals (Basel) 2025 May 30;15(11).
          doi: 10.3390/ani15111604pubmed: 40509070google scholar: lookup
        4. Parra-Moyano LA, Cedeño A, Darby S, Johnson JP, Gomez DE. Blood and Peritoneal Lactate, Ratio and Difference, and Peritoneal Lactate to Total Solids Ratio for Detection of Intestinal Strangulating Obstructions in Horses. J Vet Intern Med 2025 Jul-Aug;39(4):e70121.
          doi: 10.1111/jvim.70121pubmed: 40448701google scholar: lookup
        5. Martin E, Sarkan K, Viall A, Hostetter S, Epstein K. Clinicopathologic Parameters of Peritoneal Fluid as Predictors of Gastrointestinal Lesions, Complications, and Outcomes in Equine Colic Patients: A Retrospective Study. Animals (Basel) 2024 Dec 24;15(1).
          doi: 10.3390/ani15010012pubmed: 39794955google scholar: lookup
        6. Bayless RL, Cooper BL, Sheats MK. Extracted Plasma Cell-Free DNA Concentrations Are Elevated in Colic Patients with Systemic Inflammation. Vet Sci 2024 Sep 12;11(9).
          doi: 10.3390/vetsci11090427pubmed: 39330806google scholar: lookup
        7. Rapezzano G, Marcatili M, Stephenson R, Pereira R, Hallowell G, Duz M. Evaluation of peritoneal l-lactate concentration in horses in the early post-partum period. Vet Med Sci 2024 May;10(3):e1352.
          doi: 10.1002/vms3.1352pubmed: 38634206google scholar: lookup
        8. Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic. Animals (Basel) 2023 Jan 7;13(2).
          doi: 10.3390/ani13020227pubmed: 36670767google scholar: lookup
        9. Martín-Cuervo M, Gracia-Calvo LA, Macías-García B, Ezquerra LJ, Barrera R. Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses. Animals (Basel) 2022 Dec 15;12(24).
          doi: 10.3390/ani12243547pubmed: 36552467google scholar: lookup
        10. Cummings CO, Krucik DDR, Price E. Clinical predictive models in equine medicine: A systematic review. Equine Vet J 2023 Jul;55(4):573-583.
          doi: 10.1111/evj.13880pubmed: 36199162google scholar: lookup
        11. Dybkjær E, Steffensen KF, Honoré ML, Dinesen MA, Christophersen MT, Pihl TH. Short-term survival rates of 1397 horses referred for colic from 2010 to 2018. Acta Vet Scand 2022 May 7;64(1):11.
          doi: 10.1186/s13028-022-00631-4pubmed: 35526044google scholar: lookup
        12. Farrell A, Kersh K, Liepman R, Dembek KA. Development of a Colic Scoring System to Predict Outcome in Horses. Front Vet Sci 2021;8:697589.
          doi: 10.3389/fvets.2021.697589pubmed: 34692803google scholar: lookup
        13. Barton AK, Richter IG, Ahrens T, Merle R, Alalwani A, Lilge S, Purschke K, Barnewitz D, Gehlen H. MMP-9 Concentration in Peritoneal Fluid Is a Valuable Biomarker Associated with Endotoxemia in Equine Colic. Mediators Inflamm 2021;2021:9501478.
          doi: 10.1155/2021/9501478pubmed: 33488296google scholar: lookup
        14. Witkowska-Piłaszewicz O, Cywińska A, Michlik-Połczyńska K, Czopowicz M, Strzelec K, Biazik A, Parzeniecka-Jaworska M, Crisman M, Witkowski L. Variations in haematological and biochemical parameters in healthy ponies. BMC Vet Res 2021 Jan 19;17(1):38.
          doi: 10.1186/s12917-020-02741-5pubmed: 33468115google scholar: lookup
        15. DeNotta SL, Divers TJ. Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver. Vet Clin North Am Equine Pract 2020 Apr;36(1):105-120.
          doi: 10.1016/j.cveq.2019.11.004pubmed: 31982231google scholar: lookup
        16. Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr, Fogle CA, Gonzalez LM. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg 2020 Apr;49(3):472-479.
          doi: 10.1111/vsu.13361pubmed: 31916608google scholar: lookup
        17. Roth TL, Switzer A, Watanabe-Chailland M, Bik EM, Relman DA, Romick-Rosendale LE, Ollberding NJ. Reduced Gut Microbiome Diversity and Metabolome Differences in Rhinoceros Species at Risk for Iron Overload Disorder. Front Microbiol 2019;10:2291.
          doi: 10.3389/fmicb.2019.02291pubmed: 31649637google scholar: lookup
        18. Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O'Rourke D, Yang LV. GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis. Biochim Biophys Acta Mol Basis Dis 2017 Feb;1863(2):569-584.
          doi: 10.1016/j.bbadis.2016.12.005pubmed: 27940273google scholar: lookup
        19. Cao S, Liu P, Zhu H, Gong H, Yao J, Sun Y, Geng G, Wang T, Feng S, Han M, Zhou J, Xu Y. Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions. PLoS One 2015;10(9):e0137221.
          doi: 10.1371/journal.pone.0137221pubmed: 26340269google scholar: lookup
        20. Pihl TH, Scheepers E, Sanz M, Goddard A, Page P, Toft N, Andersen PH, Jacobsen S. Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic. J Vet Intern Med 2015 Mar-Apr;29(2):651-8.
          doi: 10.1111/jvim.12542pubmed: 25644457google scholar: lookup
        21. Grulke S, Franck T, Gangl M, Péters F, Salciccia A, Deby-Dupont G, Serteyn D. Myeloperoxidase assay in plasma and peritoneal fluid of horses with gastrointestinal disease. Can J Vet Res 2008 Jan;72(1):37-42.
          pubmed: 18214160
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