Evaluation of sodium carboxymethylcellulose for prevention of experimentally induced abdominal adhesions in ponies.
Abstract: Twelve ponies were used to evaluate the reliability of an abdominal adhesion model and the efficacy of intraperitoneal infusion of sodium carboxymethylcellulose in preventing abdominal adhesions. A celiotomy was performed on each of the 12 ponies and the serosa of the distal portion of the jejunum was abraded with a dry gauze sponge at 5 locations. In addition to the serosal damage, a single 2-0 chromic gut suture was placed through the seromuscular layer of the jejunum in the center of the abraded area. After closure of the celiotomy, a 1% solution of sodium carboxymethylcellulose (7 ml/kg of body weight) was infused into the peritoneal cavity of 6 ponies. The other ponies served as untreated controls. All ponies were euthanatized 14 days after surgery. All ponies in the control group had abdominal adhesions at the time of necropsy. Four of the 6 ponies in the treatment group were free of adhesions. There was a significant (P less than 0.0001) difference in the total number of adhesions between the 2 groups.
Publication Date: 1991-01-01 PubMed ID: 2021260
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- Journal Article
Summary
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This research tested the effectiveness of a compound, sodium carboxymethylcellulose, in preventing abdominal adhesions in ponies after surgical procedures. The results suggest that sodium carboxymethylcellulose can significantly reduce the occurrence of abdominal adhesions.
Objective and Methodology
- The study’s purpose was to assess the effectiveness of a sodium carboxymethylcellulose solution in preventing abdominal adhesions in ponies. Abdominal adhesions are fibrous bands that form between tissues and organs in the abdomen following surgery or infection. They can cause complications such as chronic pain and bowel obstruction.
- The researchers used 12 ponies for the experiment. They induced abdominal adhesions in all the animals through a surgical procedure (celiotomy), in which a part of the jejunum (part of the small intestine) was intentionally abraded.
- The ponies were divided into two groups – a control group and a treatment group. The treatment group received an intraperitoneal infusion of a 1% sodium carboxymethylcellulose solution after the surgical procedure.
Findings
- After 14 days, all ponies were euthanized, and a necropsy was performed to evaluate the presence of abdominal adhesions.
- All the ponies in the control group had abdominal adhesions, while four out of six ponies in the treatment group were adhesion-free.
- The researchers found a significant difference in the total number of adhesions between the two groups. This suggests that sodium carboxymethylcellulose, infused into the peritoneal cavity after a surgical procedure, could play a role in preventing the formation of abdominal adhesions.
Implications
- Given the common occurrence of abdominal adhesions post-surgery and the potential complications they can cause, this is a valuable finding.
- Moreover, it suggests that sodium carboxymethylcellulose could be considered as a preventive measure in surgeries with a high risk of inducing abdominal adhesions, potentially improving surgical outcomes and patients’ subsequent quality of life.
Cite This Article
APA
Moll HD, Schumacher J, Wright JC, Spano JS.
(1991).
Evaluation of sodium carboxymethylcellulose for prevention of experimentally induced abdominal adhesions in ponies.
Am J Vet Res, 52(1), 88-91.
Publication
Researcher Affiliations
- Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Auburn University, AL 36849-5522.
MeSH Terms
- Animals
- Carboxymethylcellulose Sodium / therapeutic use
- Drug Evaluation
- Horse Diseases / chemically induced
- Horse Diseases / prevention & control
- Horse Diseases / surgery
- Horses
- Infusions, Parenteral / methods
- Infusions, Parenteral / veterinary
- Peritoneal Diseases / chemically induced
- Peritoneal Diseases / prevention & control
- Peritoneal Diseases / veterinary
- Tissue Adhesions / chemically induced
- Tissue Adhesions / prevention & control
- Tissue Adhesions / veterinary
Citations
This article has been cited 5 times.- Alonso Jde M, Alves AL, Watanabe MJ, Rodrigues CA, Hussni CA. Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies.. Vet Med Int 2014;2014:279730.
- Hoare T, Yeo Y, Bellas E, Bruggeman JP, Kohane DS. Prevention of peritoneal adhesions using polymeric rheological blends.. Acta Biomater 2014 Mar;10(3):1187-93.
- Yu CH, Lee JH, Baek HR, Nam H. The effectiveness of poloxamer 407-based new anti-adhesive material in a laminectomy model in rats.. Eur Spine J 2012 May;21(5):971-9.
- Singer ER, Livesey MA, Barker IK, Hurtig MB, Conlon PD. Utilization of the serosal scarification model of postoperative intestinal adhesion formation to investigate potential adhesion-preventing substances in the rabbit.. Can J Vet Res 1996 Oct;60(4):305-11.
- Singer ER, Livesey MA, Barker IK, Hurtig MB, Conlon PD. Development of a laboratory animal model of postoperative small intestinal adhesion formation in the rabbit.. Can J Vet Res 1996 Oct;60(4):296-304.
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