Evaluation of Telocytes in the Ovary, Oviduct and Uterus of Kyrgyz Mares According to Pregnancy Status.
Abstract: In the current study, we aimed to determine the distribution of telocytes in the ovary, oviduct and uterus of Kyrgyz mares depending on whether they were pregnant. We also studied the progression during the first 6 months of pregnancy. To this end, ovary, oviduct and uterus tissues from 53 Kyrgyz mares were obtained post-mortem. The mare tissue samples were divided into two groups: pregnant (n = 43) and non-pregnant (n = 10). Telocyte levels in the tissues were determined using light microscopic and immunohistochemical methods. Subsequently, the data acquired were evaluated based on whether the mare was pregnant, and if so, the month of pregnancy was also taken into account. After the study, we found a higher number of telocytes in the myometrium (5.69 ± 0.90, p < 0.001) and oviduct propria (0.14 ± 0.05, p < 0.006) of pregnant mares. We also noted an increased number of telocytes in the oviduct propria (0.04 ± 0.02, p < 0.03) of mares 4 months into the pregnancy, and in the muscle layer (1.62 ± 0.57, p < 0.01), myometrium (4.83 ± 0.78, p < 0.03) and ovarian stroma (0.14 ± 0.06, p < 0.04) of mares 6 months into pregnancy. In conclusion, we observed an increase in telocytes in the ovaries, oviducts and uterus of Kyrgyz mares during pregnancy, with this increase becoming more marked towards the sixth month of gestation. Therefore, additional research on the role of telocytes in pregnancy may prove beneficial.
© 2025 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.
Publication Date: 2025-02-19 PubMed ID: 39968722DOI: 10.1111/ahe.70024Google Scholar: Lookup
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Summary
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This research study aims to observe the distribution of telocytes, a type of cell, within the reproductive organs (ovary, oviduct and uterus) of Kyrgyz mares, particularly focusing on differences between pregnant and non-pregnant mares, as well as changes during the early stages of pregnancy.
Methodology
- The researchers used reproductive organ tissues from a total of 53 Kyrgyz mares, which were collected post-mortem.
- The mares were classified into two groups: those that were pregnant at the time of tissue collection (43 mares) and those that were not pregnant (10 mares).
- To identify and count the telocytes within the tissues, light microscope and immunohistochemical staining techniques were applied.
- The resulting data was then analyzed with respect to the pregnancy status of the mares and, in the case of pregnant mares, the current month of gestation was also considered.
Results
- Greater numbers of telocytes were found in the myometrium (the middle layer of the uterus wall) and in the oviduct propria (the supportive tissue surrounding the tube connecting the ovary and the uterus) of pregnant mares compared to non-pregnant mares.
- For mares four months into pregnancy, an increase in telocytes was specifically noticed in their oviduct propria.
- At the six-month pregnancy mark, increases in telocytes were observed in the muscle layer and myometrium (both part of the uterus), as well as in the ovarian stroma (the supportive tissue of the ovary).
Conclusion
- The study concludes that there is a discernible increase in telocyte distribution in the reproductive organs of mares during pregnancy, with a more pronounced increase towards the sixth month of pregnancy.
- Given these results, the research suggests potential benefits in further investigations into the role of telocytes during pregnancy.
Cite This Article
APA
Risvanli A, Hatipoglu F, Salykov R, Timurkaan N, Kadiralieva N, Kasymalieva KK, Seker I, Ekinci E.
(2025).
Evaluation of Telocytes in the Ovary, Oviduct and Uterus of Kyrgyz Mares According to Pregnancy Status.
Anat Histol Embryol, 54(2), e70024.
https://doi.org/10.1111/ahe.70024 Publication
Researcher Affiliations
- Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
- Faculty of Veterinary Medicine, Firat University, Elazığ, Türkiye.
- Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
- Faculty of Veterinary Medicine, Selcuk University, Konya, Türkiye.
- Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
- Faculty of Veterinary Medicine, Firat University, Elazığ, Türkiye.
- Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
- Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
- Faculty of Veterinary Medicine, Firat University, Elazığ, Türkiye.
- Faculty of Veterinary Medicine, Dicle University, Diyarbakır, Türkiye.
MeSH Terms
- Animals
- Female
- Horses / anatomy & histology
- Pregnancy
- Uterus / cytology
- Uterus / anatomy & histology
- Ovary / anatomy & histology
- Ovary / cytology
- Telocytes / cytology
- Oviducts / anatomy & histology
- Oviducts / cytology
- Pregnancy, Animal / physiology
- Myometrium / cytology
- Myometrium / anatomy & histology
- Immunohistochemistry / veterinary
- Fallopian Tubes / cytology
- Fallopian Tubes / anatomy & histology
Grant Funding
- (KTMU-BAP-2024.FB.02) / Kyrgyzstan Turkey Manas University Scientific Research Projects Unit
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