Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses.
Abstract: To evaluate effects of IV administration of penicillin G potassium (KPEN) or potassium chloride (KCl) on defecation and myoelectric activity of the cecum and pelvic flexure of horses. Methods: 5 healthy horses. Methods: Horses with 12 bipolar electrodes on the cecum and pelvic flexure received KPEN or KCl solution by IV bolus 4 hours apart. Each horse received the following: 2 X 10(7) U of KPEN (high-dose KPEN) followed by 34 mEq of KCl (high-dose KCl), 1 X 10(7) U of KPEN (low-dose KPEN) followed by 17 mEq of KCl (low-dose KCl), high-dose KCl followed by high-dose KPEN, and low-dose KCl followed by low-dose KPEN. Number of defecations and myoelectric activity were recorded for 60 minutes. The first three 5-minute segments and first four 15-minute segments of myoelectric activity were analyzed. Results: Number of defecations during the first 15-minute segment was greater after high-dose KPEN treatment than after high-dose or low-dose KCl treatment. Compared with reference indexes, myoelectric activity was greater in the pelvic flexure for the first 5-minute segment after high-dose KCl treatment, in the cecum and pelvic flexure for the first 5-minute segment and in the pelvic flexure for the first 15-minute segment after low-dose KPEN treatment, and in the pelvic flexure for the first and second 5-minute segments and the first three 15-minute segments after high-dose KPEN treatment. Conclusions: IV administration of KPEN stimulates defecation and myoelectric activity of the cecum and pelvic flexure in horses. Effects of KPEN may be beneficial during episodes of ileus.
Publication Date: 2003-11-19 PubMed ID: 14620770DOI: 10.2460/ajvr.2003.64.1360Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research examined the impact of intravenous (IV) delivery of penicillin G potassium (KPEN) or potassium chloride (KCl) on the defecation and myoelectric activity of specific sections of large intestines in horses, with the results pointing towards the stimulatory effect of KPEN in these physiological processes.
Methodology
- The researchers recruited 5 healthy horses for this study.
- 12 bipolar electrodes were mounted on these horses’ cecum and pelvic flexure to monitor myoelectric activity.
- Horses received either penicillin G potassium (KPEN) or potassium chloride (KCl) intravenously with two different dosage levels.
- The effect of the substances was measured by the number of defecations and the record of myoelectric activity for 60 minutes.
- Information from early segments of the recorded myoelectric activity data was analyzed to establish the effects of each substance.
Results
- The number of defecations within the first 15 minutes was found to increase after high-dose KPEN treatment compared to both high-dose and low-dose KCl treatments.
- Myoelectric activity (indicative of bowel movements and function) increased in the pelvic flexure during the first 5-minute segment after high-dose KCl treatment.
- Low-dose KPEN treatment led to increased myoelectric activity in both the cecum and pelvic flexure in the initial 5-minute segment and specifically in the pelvic flexure in the first 15-minute segment.
- The high-dose KPEN administration resulted in augmented myoelectric activity in the pelvic flexure for the first two 5-minute segments and the first three 15-minute segments.
Conclusions
- Administering KPEN intravenously appears to have a stimulating effect on defecation and myoelectric activity in the cecum and pelvic flexure of horses.
- This indicates a potential use of KPEN for easing episodes of ileus, a painful condition caused by an obstruction or lack of activity in the intestines, in horses.
Cite This Article
APA
Roussel AJ, Hooper RN, Cohen ND, Bye AD, Hicks RJ, Schulze JL.
(2003).
Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses.
Am J Vet Res, 64(11), 1360-1363.
https://doi.org/10.2460/ajvr.2003.64.1360 Publication
Researcher Affiliations
- Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA.
MeSH Terms
- Animals
- Colon / drug effects
- Colon / physiology
- Dose-Response Relationship, Drug
- Female
- Gastrointestinal Motility / drug effects
- Horses / physiology
- Intestine, Large / drug effects
- Intestine, Large / physiology
- Male
- Muscle, Smooth / drug effects
- Muscle, Smooth / physiology
- Penicillin G / pharmacology
- Potassium Chloride / pharmacology
Citations
This article has been cited 1 times.- Tabar JJ, Cruz AM. Cecal rupture in foals--7 cases (1996-2006). Can Vet J 2009 Jan;50(1):65-70.
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