Evaluation of the sublingual microcirculation with sidestream dark field video microscopy in horses anesthetized for an elective procedure or intestinal surgery.
Abstract: To compare the sublingual microcirculation between healthy horses anesthetized for elective procedures and horses with colic anesthetized for abdominal surgery and to determine the effect of mean arterial blood pressure (MAP) on the microcirculation. Methods: 9 horses in the elective group and 8 horses in the colic group. Methods: Sublingual microcirculation was assessed with sidestream dark field video microscopy. Videos were captured at 3 time points during anesthesia. Recorded microvasculature parameters were De Backer score (DBS), total density of perfused vessels (PVD) and small vessels (PVD-S), total proportion of perfused vessels (PPV) and small vessels (PPV-S), vascular flow index (MFI), and heterogeneity index (HI). Blood pressure during hypotensive (MAP < 60 mm Hg) and normotensive (MAP ≥ 60 mm Hg) episodes was also recorded. Results: During normotensive episodes, the elective group had significantly better PPV and PPV-S versus the colic group (median PPV, 76% vs 50%; median PPV-S, 73% vs 51%). In both groups, PPV decreased during anesthesia (elective group, -29%; colic group, -16%) but significantly improved in the elective group 15 minutes before the end of anesthesia (59%). During hypotensive episodes, PVD-S was better preserved in the colic group (11.1 vs 3.8 mm/mm). No differences were identified for the microcirculatory parameters between normo- and hypotensive episodes in the colic group. Conclusions: Sublingual microcirculation was better preserved in healthy horses anesthetized for elective procedures than in horses with colic anesthetized for abdominal surgery despite resuscitation maneuvers. Results indicated that the macrocirculation and microcirculation in critically ill horses may be independent.
Publication Date: 2021-06-25 PubMed ID: 34166089DOI: 10.2460/ajvr.82.7.574Google Scholar: Lookup
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- Journal Article
Summary
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The research article examines the differences in the sublingual microcirculation between healthy horses under anaesthesia for elective procedures and those with colic (abdominal pain) undergoing abdominal surgery. The study identifies that the microcirculation was better preserved in healthy horses, despite attempts at resuscitation in those with colic.
Objective and Method
- The research aimed to compare the sublingual microcirculation in healthy horses and horses suffering from colic, both groups under anesthesia. The researchers also wanted to determine the impact of mean arterial blood pressure (MAP) on microcirculation.
- The study had nine horses in the healthy elective group and eight horses in the colic group.
- They used sidestream dark field video microscopy to assess sublingual microcirculation. The microvasculature was recorded at three different time points during the anesthesia.
- They observed various parameters including De Backer score (DBS), total density of perfused vessels (PVD) and small vessels (PVD-S), total proportion of perfused vessels (PPV) and small vessels (PPV-S), vascular flow index (MFI), and heterogeneity index (HI).
- The researchers also recorded blood pressure during hypotensive (MAP < 60 mm Hg) and normotensive (MAP ≥ 60 mm Hg) episodes.
Results
- The elective group of healthy horses showed significantly better performance in terms of PPV and PPV-S as compared to the colic group during normotensive episodes.
- Despite a decrease in PPV among both groups during anesthesia, the PPV of the elective group significantly improved 15 minutes before the end of anesthesia.
- The preservation of PVD-S during hypotensive circumstances was more noticeable in the colic group.
- The researchers did not find significant differences in the microcirculatory parameters between the normo- and hypotensive episodes for the colic group.
Conclusions
- The researchers discovered that sublingual microcirculation conservation was better in healthy horses under anesthesia for elective procedures than in horses with colic undergoing abdominal surgery.
- The results indicate that macrocirculation and microcirculation could operate independently in critically ill horses.
Cite This Article
APA
Mansour C, Chaaya R, Sredensek J, Mocci R, Santangelo B, Allaouchiche B, Bonnet-Garin JM, Boselli E, Junot SA.
(2021).
Evaluation of the sublingual microcirculation with sidestream dark field video microscopy in horses anesthetized for an elective procedure or intestinal surgery.
Am J Vet Res, 82(7), 574-581.
https://doi.org/10.2460/ajvr.82.7.574 Publication
Researcher Affiliations
- From the APCSe Unit UPSP 2016.A101, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Department of Pharmacology, Faculty of Agronomy and Veterinary Medicine, Lebanese University, Beirut, Lebanon.
- From the Anesthesia Service at the Veterinary Campus of Lyon, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Anesthesia Service at the Veterinary Campus of Lyon, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Anesthesia Service at the Veterinary Campus of Lyon, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the APCSe Unit UPSP 2016.A101, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Lyon University Hospital Center, ICU, 69310 Pierre-Bénite, France.
- From the APCSe Unit UPSP 2016.A101, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the APCSe Unit UPSP 2016.A101, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Department of Anesthesia, Hospital Center Pierre Oudot, 38300 Bourgoin-Jallieu, France.
- From the APCSe Unit UPSP 2016.A101, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
- From the Anesthesia Service at the Veterinary Campus of Lyon, VetAgro Sup, University of Lyon, 69280 Marcy-l'Étoile, France.
MeSH Terms
- Animals
- Digestive System Surgical Procedures / veterinary
- Hemodynamics
- Horses
- Microcirculation
- Microscopy, Video / veterinary
- Mouth Floor / surgery
Citations
This article has been cited 3 times.- Freccero F, Di Maio C, Mariella J, Lanci A, Castagnetti C, Hallowell G. Assessment of the microvascular perfusion using sidestream dark-field imaging in healthy newborn foals.. Vet Med Sci 2023 Jan;9(1):158-166.
- Lawrence-Mills SJ, Hughes D, Hezzell MJ, Butler M, Neal C, Foster RR, Welsh GI, Finch N. The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine.. Vet J 2022 Jul;285:105843.
- Lawrence-Mills SJ, Neal CR, Satchell SC, Welsh GI, Foster RR, Finch N. Visualising the endothelial glycocalyx in dogs.. Vet J 2022 Jul;285:105844.
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