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Evidence of respiratory tract infection induced by equine herpesvirus, type 2, in the horse.
Abstract: Five horses were experimentally exposed to equine herpesvirus 2 strain LK. Two young foals developed chronic pharyngitis (98 and 232 days, respectively). Growth characteristics, cytopathic effects (CPE), inclusion body formation, ether sensitivity, and immunofluorescent analysis indicated that the virus recovered from infected animals was a herpesvirus serologically identical with, or at least antigenically related to EHV-2 strain LK. No significant complement-fixing (CF) or virus-neutralizing (VN) antibody responses were observed in adult horses while both foals demonstrated a rise in CF antibody titer. One of the two foals demonstrated a rise in VN antibody only. The results suggest that EHV-2 virus induced chronic pharyngitis, primarily the result of lymphoid proliferation, with no overt clinical signs.
Publication Date: 1975-12-01 PubMed ID: 175904DOI: 10.1139/m75-281Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigates how exposure to equine herpesvirus 2 can lead to chronic throat inflammation (pharyngitis) in horses, particularly foals. It shows that the recovered virus is serologically similar to the EHV-2 strain and triggers an immune response in foals, but not in adult horses.
Experiment Overview
- The study experimented on five horses that were exposed to a strain of equine herpesvirus 2 (EHV-2), identified as the ‘LK’ strain.
- Notably, two young foals developed chronic pharyngitis or throat inflammation that lasted for 98 and 232 days, respectively.
Virus Characteristics
- The researchers observed various aspects of the virus, such as its growth characteristics, cytopathic effects (changes caused by virus growth in host cells), the formation of inclusion bodies, sensitivity to ether, and immunofluorescent analysis.
- The findings revealed that the virus recovered from the infected horses was similar to the EHV-2 strain ‘LK’, confirmed through several tests proving it to be a herpesvirus.
Immune Response
- There were no detectable complement-fixing (CF) or virus-neutralizing (VN) antibody responses in the adult horses in the experiment. These reactions are key components of an immune system’s response to infection.
- However, an increase in CF antibody titer (a measure of the concentration of antibodies in the blood) was observed in both foals. One of the two foals also showed a rise in VN antibodies. These responses indicate an immune response to the invading virus.
Conclusion
- The results suggest that the EHV-2 virus can trigger chronic pharyngitis in horses, linked mainly with lymphoid proliferation (an increase in the number of cells that produce antibodies).
- Interestingly, no overt clinical signs were noted, suggesting that the symptoms of the disease might be mild or not easily observable.
Cite This Article
APA
Blakeslee JR, Olsen RG, McAllister ES, Fassbender J, Dennis R.
(1975).
Evidence of respiratory tract infection induced by equine herpesvirus, type 2, in the horse.
Can J Microbiol, 21(12), 1940-1946.
https://doi.org/10.1139/m75-281 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antibody Formation
- Antigens, Viral / analysis
- Chronic Disease
- Culture Techniques
- Female
- Herpesviridae / growth & development
- Herpesviridae / immunology
- Herpesviridae Infections / veterinary
- Horse Diseases / microbiology
- Horses
- Male
- Pharyngitis / microbiology
- Pharyngitis / veterinary
Citations
This article has been cited 16 times.- Badr C, Souiai O, Arbi M, El Behi I, Essaied MS, Khosrof I, Benkahla A, Chabchoub A, Ghram A. Epidemiological and Phylogeographic Study of Equid Herpesviruses in Tunisia. Pathogens 2022 Sep 5;11(9).
- Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1. EFSA J 2022 Jan;20(1):e07036.
- Thorsteinsdóttir L, Jónsdóttir S, Stefánsdóttir SB, Andrésdóttir V, Wagner B, Marti E, Torsteinsdóttir S, Svansson V. The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response. PLoS One 2019;14(6):e0218576.
- Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. Gammaherpesvirus infections in equids: a review. Vet Med (Auckl) 2015;6:91-101.
- LeCuyer TE, Rink A, Bradway DS, Evermann JF, Nicola AV, Baszler T, Haldorson GJ. Abortion in a Mediterranean miniature donkey (Equus asinus) associated with a gammaherpesvirus similar to Equid herpesvirus 7. J Vet Diagn Invest 2015 Nov;27(6):749-53.
- Prescott JF, Wilcock BP, Carman PS, Hoffman AM. Sporadic, severe bronchointerstitial pneumonia of foals. Can Vet J 1991 Jul;32(7):421-5.
- Craig MI, Barrandeguy ME, Fernández FM. Equine herpesvirus 2 (EHV-2) infection in thoroughbred horses in Argentina. BMC Vet Res 2005 Nov 9;1:9.
- Thome M, Gaide O, Micheau O, Martinon F, Bonnet D, Gonzalez M, Tschopp J. Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10. J Cell Biol 2001 Mar 5;152(5):1115-22.
- Drummer HE, Reubel GH, Studdert MJ. Equine gammaherpesvirus 2 (EHV2) is latent in B lymphocytes. Arch Virol 1996;141(3-4):495-504.
- Rode HJ, Bugert JJ, Handermann M, Schnitzler P, Kehm R, Janssen W, Delius H, Darai G. Molecular characterization and determination of the coding capacity of the genome of equine herpesvirus type 2 between the genome coordinates 0.235 and 0.258 (the EcoRI DNA fragment N; 4.2 kbp). Virus Genes 1994 Sep;9(1):61-75.
- Browning GF, Studdert MJ. Epidemiology of equine herpesvirus 2 (equine cytomegalovirus). J Clin Microbiol 1987 Jan;25(1):13-6.
- Browning GF, Studdert MJ. Physical mapping of a genome of equine herpesvirus 2 (equine cytomegalovirus). Arch Virol 1989;104(1-2):77-86.
- Browning GF, Ficorilli N, Studdert MJ. Asinine herpesvirus genomes: comparison with those of the equine herpesviruses. Arch Virol 1988;101(3-4):183-90.
- Browning GF, Studdert MJ. Physical mapping of the genomic heterogeneity of isolates of equine herpesvirus 2 (equine cytomegalovirus). Arch Virol 1989;104(1-2):87-94.
- Staczek J. Animal cytomegaloviruses. Microbiol Rev 1990 Sep;54(3):247-65.
- Gutekunst DE, Malmquist WA, Becvar CS. Antigenic relatedness of equine herpes virus types 1 and 3. Arch Virol 1978;56(1-2):33-45.
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