Factors associated with failure of passive transfer of colostral antibodies in Standardbred foals.

The research article discusses a study conducted to figure out factors associated with the failure of passive transfer of colostral antibodies in Standardbred foals. It found that the foaling season and foal exam score were major factors influencing such failure, which subsequently led to the need for medical treatment in foals.

Study Design

• This research focused on examining the records of 361 Standardbred mares and their offspring born in 1986 or 1987.
• The goal was to identify any correlations or factors related to the failure of passive transfer (FPT) of colostral antibodies for newborn foals.
• Sixty-five foals, or roughly 18% of the study group, were identified as having FPT. This conclusion was based on their serum immunoglobulin concentration registering at less than 400 mg/dl at between 24 to 36 hours of age as determined by the glutaraldehyde coagulation test.

Main Findings

• An array of multiple logistic regression models were reviewed to assess the possible association of mare and foal-related factors with FPT.
• Two primary factors were found to be associated with the development of FPT. These were the season in which the mare foaled and the foal exam score, which is a subjective assessment of a foal’s overall vigor, maturity, and general health.

Implication of FPT

• The study found that foals with FPT are more likely to require medical therapy during their initial three months after birth.
• The odds ratio was determined at 3.50 with a 95% confidence interval of 1.81-6.68 which indicates a significant increase in likelihood for FPT foals needing medical intervention compared to regular foals.