Factors associated with the risk of developing sarcoid tumours in horses.
Abstract: A retrospective case-control study was conducted to identify risk factors in horses associated with the development of the common skin tumours known as sarcoids. The study involved 503 sarcoid cases diagnosed (January 1980-December 1989) at New York State College of Veterinary Medicine and a similar number of controls (non-sarcoid cases). Data on age, breed and sex of cases and controls were obtained from computerised records. Multiple logistic regression analysis was used to identify risk factors. Separate data were obtained for the same 10-year period from the Veterinary Medical Data Program to determine the proportional morbidity rate at different veterinary colleges in North America. Appaloosa, Arabian and Quarter horses were at a higher risk of developing sarcoid tumours than were Thoroughbred horses. Standardbred horses had a lower risk of developing sarcoids. Geldings were at a higher risk of developing sarcoids in comparison with stallions. There was no significant difference in the risk of developing sarcoids between stallions and mares. The risk of developing sarcoid increased with age up to 15 years and then declined. The proportional morbidity rate of sarcoids among the veterinary colleges ranged between 0 and 14 per 1,000 cases, with an average of 6 per 1,000.
Publication Date: 1992-05-01 PubMed ID: 1606927DOI: 10.1111/j.2042-3306.1992.tb02808.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research investigates the risk factors that are associated with the development of skin tumors, known as sarcoids, in horses. The study finds that certain breeds, gender, and age affect the likelihood of a horse developing these tumors.
Methodology
- The researchers conducted a retrospective case-control study, where they went through past records to identify patterns or correlations. This approach was used because sarcoids occur over a long period and you can’t start a study today and simply wait for sarcoids to develop.
- The study included 503 horses that were diagnosed with sarcoids between January 1980 and December 1989 at the New York State College of Veterinary Medicine.
- The control group was of similar size and comprised horses that did not have sarcoids during the same period.
- Data on the age, breed, and sex of the horses were obtained from computerized records.
- This information was analyzed using multiple logistic regression, a statistical method that helps understand how different characteristics (age, breed, sex) influence a certain outcome (in this case, the development of sarcoids).
Results
- The study found that certain breeds including the Appaloosa, Arabian, and Quarter horses were more likely to develop sarcoids than Thoroughbred horses.
- Standardbred horses, on the other hand, had a lower risk of developing these skin tumors.
- The researchers also found that geldings (neutered male horses) had a higher risk of developing sarcoids compared to stallions (intact male horses).
- However, they found no significant difference in risk between stallions and mares (female horses).
- The risk of developing sarcoids increased with age, becoming most likely up until 15 years, and then declining afterwards.
Proportional morbidity rate
- The researchers also obtained data from the Veterinary Medical Data Program, which had incidence rates of sarcoids in different veterinary colleges across North America.
- This provided them with a snapshot of how common these tumors were across the wider horse population.
- They found that the proportional morbidity rate — essentially the percentage of horses with sarcoids among all horses seen by the colleges — ranged from 0 to 14 per 1,000 cases, with an average rate of 6 per 1,000.
Cite This Article
APA
Mohammed HO, Rebhun WC, Antczak DF.
(1992).
Factors associated with the risk of developing sarcoid tumours in horses.
Equine Vet J, 24(3), 165-168.
https://doi.org/10.1111/j.2042-3306.1992.tb02808.x Publication
Researcher Affiliations
- Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
MeSH Terms
- Age Factors
- Animals
- Breeding
- Case-Control Studies
- Female
- Horse Diseases / epidemiology
- Horse Diseases / etiology
- Horses
- Leiomyoma / epidemiology
- Leiomyoma / etiology
- Leiomyoma / veterinary
- Male
- Morbidity
- Multivariate Analysis
- New York / epidemiology
- Retrospective Studies
- Risk Factors
- Sex Factors
- Skin Neoplasms / epidemiology
- Skin Neoplasms / etiology
- Skin Neoplasms / veterinary
Citations
This article has been cited 8 times.- Bogaert L, Woodham AW, Da Silva DM, Martens A, Meyer E, Kast WM. A novel murine model for evaluating bovine papillomavirus prophylactics/therapeutics for equine sarcoid-like tumours. J Gen Virol 2015 Sep;96(9):2764-2768.
- Wobeser BK, Davies JL, Hill JE, Jackson ML, Kidney BA, Mayer MN, Townsend HG, Allen AL. Epidemiology of equine sarcoids in horses in western Canada. Can Vet J 2010 Oct;51(10):1103-8.
- Penell JC, Bonnett BN, Pringle J, Egenvall A. Validation of computerized diagnostic information in a clinical database from a national equine clinic network. Acta Vet Scand 2009 Dec 10;51(1):50.
- Carstanjen B, Jordan P, Lepage OM. Carbon dioxide laser as a surgical instrument for sarcoid therapy--a retrospective study on 60 cases. Can Vet J 1997 Dec;38(12):773-6.
- Reid SW, Mohammed HO. Longitudinal and cross-sectional studies to evaluate the risk of sarcoid associated with castration. Can J Vet Res 1997 Apr;61(2):89-93.
- Broström H. Equine sarcoids. A clinical and epidemiological study in relation to equine leucocyte antigens (ELA). Acta Vet Scand 1995;36(2):223-36.
- Vychodilova L, Plasil M, Futas J, Kopecka A, Molinkova D, Wijacki T, Jahn P, Knoll A, Horin P. Genetic susceptibility to sarcoid in Arabian horses: associations with MHC class II and compound MHC class I/KLRA genotypes. Vet Res Commun 2025 May 1;49(3):184.
- Quatember H, Nell B, Richter B, Rigler D, Dolezal M, Sykora S, Wallner B. Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid. Animals (Basel) 2025 Mar 22;15(7).
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