Field efficacy of ivermectin plus praziquantel oral paste against naturally acquired gastrointestinal nematodes and cestodes of horses in North America and Europe.
Abstract: The efficacy of an oral formulation of ivermectin plus praziquantel in the reduction of nematode and cestode egg counts in horses was assessed in 273 horses under field conditions at 15 sites in North America (n = 6) and Europe (n = 9). Horses were confirmed by fecal examination to have natural infections of strongyles (100%) and tapeworms (76%). Replicates of four horses were formed at each site, and in each replicate three animals received ivermectin (0.2 mg/kg body weight) plus praziquantel (1 mg/kg body weight) oral paste and one animal remained untreated or received vehicle paste. Fecal samples were collected for fecal nematode and cestode egg counting before and 7, 8, 9, 14, 15, and 16 days after treatment. Horses treated with ivermectin plus praziquantel oral paste had significantly (P <.01) lower posttreatment strongylid and cestode egg counts (reductions of 98% or more) than controls. Combined site analyses revealed that 95% or 96% of the horses positive for cestode eggs before treatment that were treated with ivermectin plus praziquantel were negative for cestode eggs at each posttreatment fecal examination. No adverse reactions attributable to ivermectin plus praziquantel oral paste treatments were observed. The results of the studies demonstrated that ivermectin plus praziquantel paste was highly effective in reducing egg shedding by gastrointestinal nematodes and cestodes, and no adverse reactions were observed in horses treated under field conditions.
Publication Date: 2004-05-12 PubMed ID: 15136982
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- Clinical Trial
- Journal Article
- Multicenter Study
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research article assesses the effectiveness of an oral paste made from ivermectin and praziquantel in reducing the egg counts of nematode and cestode parasites in horses. The study, conducted in North America and Europe, found that the paste was highly effective in reducing the shedding of parasite eggs without causing any noticeable adverse reactions in the horses.
Study Setup
- The study was conducted in 15 different sites in North America (6 sites) and Europe (9 sites) involving a total of 273 horses.
- All the horses in the study were tested using fecal examination to confirm the presence of natural infections of strongyles (a type of parasitic worm) and tapeworms.
- Each site had replicates of four horses with each replicate including three horses treated with the oral paste, and one untreated or treated with vehicle paste.
Treatment and Assessment
- The treated horses received an oral paste comprised of ivermectin (0.2 mg/kg of body weight) and praziquantel (1 mg/kg of body weight).
- Fecal samples were collected at various intervals before and after treatment to count the number of nematode and cestode eggs. These intervals were on the days 7, 8, 9, 14, 15, and 16 after treatment.
- Results indicated that the horses treated with the oral paste had substantially lower post-treatment strongylid (another variety of parasitic worm) and cestode egg counts. The reductions were 98% or more and were statistically significant.
Results and Conclusion
- Combined site analyses revealed that 95% or 96% of the horses who tested positive for cestode eggs before treatment, tested negative after the recommended ivermectin plus praziquantel treatment in each post-treatment fecal examination.
- No adverse effects attributable to the ivermectin plus praziquantel oral paste treatment were observed among the horses.
- Therefore, it was concluded that the ivermectin plus praziquantel paste was highly effective in reducing egg shedding by gastrointestinal nematodes and cestodes in horses under field conditions.
Cite This Article
APA
Rehbein S, Holste JE, Doucet MY, Fenger C, Paul AJ, Reinemeyer CR, Smith LL, Yoon S, Marley SE.
(2004).
Field efficacy of ivermectin plus praziquantel oral paste against naturally acquired gastrointestinal nematodes and cestodes of horses in North America and Europe.
Vet Ther, 4(3), 220-227.
Publication
Researcher Affiliations
- Merial GmbH, Kathrinenhof Research Center, Walchenseestr 8-12, D-83101 Rohrdorf, Germany.
MeSH Terms
- Administration, Oral
- Animals
- Anthelmintics / administration & dosage
- Cestoda
- Cestode Infections / drug therapy
- Cestode Infections / veterinary
- Chemistry, Pharmaceutical
- Drug Combinations
- Europe
- Feces / parasitology
- Female
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horse Diseases / pathology
- Horses
- Ivermectin / administration & dosage
- Male
- Praziquantel / administration & dosage
- Quebec
- Strongyle Infections, Equine / drug therapy
- Strongylida
- Treatment Outcome
- United States
Citations
This article has been cited 2 times.- Burcáková L, Königová A, Kuzmina TA, Austin CJ, Matthews JB, Lightbody KL, Peczak NA, Syrota Y, Várady M. Equine tapeworm (Anoplocephala spp.) infection: evaluation of saliva- and serum-based antibody detection methods and risk factor analysis in Slovak horse populations. Parasitol Res 2023 Dec;122(12):3037-3052.
- Getachew AM, Innocent G, Proudman CJ, Trawford A, Feseha G, Reid SW, Faith B, Love S. Field efficacy of praziquantel oral paste against naturally acquired equine cestodes in Ethiopia. Parasitol Res 2013 Jan;112(1):141-6.
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