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Home / Equine Research Bank / Parasitol Res / Field efficacy of praziquantel oral paste against naturally ...
Parasitology research2012; 112(1); 141-146; doi: 10.1007/s00436-012-3117-1

Field efficacy of praziquantel oral paste against naturally acquired equine cestodes in Ethiopia.

Abstract: The efficacy of an oral formulation of praziquantel (Equitape, Horse paste, Fort Dodge) in the reduction of cestode egg counts and serum antibody level against Anoplocephala perfoliata was assessed in 44 donkeys under field conditions. The donkeys were confirmed both by faecal examination and serum antibody assessed by an enzyme-linked immunosorbent assay to have natural infection with tapeworms. The donkeys were randomly allocated into treatment (n = 22) and control (n = 22) groups. The treatment group was treated with both praziquantel and ivermectin (Ivomec, Merial) at a dose rate of 1 mg/kg and 200 μg/kg, respectively while the control group was treated only with ivermectin. Faecal samples were collected before treatment (day-0) and 2, 6, 8, 12, and 16 weeks post-treatment while blood samples were collected before treatment and 8 and 16 weeks after treatment and analysed. The results of the study demonstrated that praziquantel paste was highly effective in reducing cestode eggs in donkeys and had an efficacy of more than 99 % until week 16 (day 112). No cestode egg reappearance by 16 weeks post-treatment in any animal in the treatment group was observed while donkeys in the control group continued shedding cestode eggs. The immunological assay also showed a significant reduction in serum antibody level against A. perfoliata in treated donkeys compared to the control group (p = 0.0001). This marked decrease in serum antibody level indicates reduced risk of cestode-associated colic and other gastrointestinal disorders and clinical diseases. No adverse reactions or clinical effects were encountered in any animal within either group throughout the trial period.
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Publication Date: 2012-09-22 PubMed ID: 23001508DOI: 10.1007/s00436-012-3117-1Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates the effectiveness of praziquantel, an antiparasitic medication, in treating naturally occurring tapeworm infections in donkeys. The research concluded that the drug effectively reduces tapeworm egg counts and serum antibody levels against the parasite.

Research Methodology

  • 44 donkeys in Ethiopia naturally infected with tapeworms were randomly divided into treatment and control groups, each containing 22 subjects.
  • The infection was confirmed through faecal examination and serum antibody testing via an enzyme-linked immunosorbent assay.
  • The treatment group was administered praziquantel and ivermectin, an antiparasitic drug commonly used in livestock, while the control group was treated only with ivermectin.
  • Faecal samples were collected before treatment (day-0) and regularly thereafter up until 16 weeks post-treatment. Blood samples were collected before treatment and at weeks 8 and 16 post-treatment for analysis.

Findings and Conclusion

  • The praziquantel proved highly effective in reducing tapeworm egg counts in donkeys, showing an efficacy rate of over 99% through to week 16 (day 112).
  • There was no reappearance of tapeworm eggs by week 16 in any donkey in the treatment group, whilst the control group continued to shed eggs.
  • An immunological assay revealed a significant decrease in serum antibody levels against the tapeworms in the treated donkeys compared to the control group (p = 0.0001), indicating a reduced risk of tapeworm-associated disorders.
  • No adverse reactions or clinical effects were noted in either group throughout the study, demonstrating that the treatment was safe as well as effective.

Cite This Article

APA
Getachew AM, Innocent G, Proudman CJ, Trawford A, Feseha G, Reid SW, Faith B, Love S. (2012). Field efficacy of praziquantel oral paste against naturally acquired equine cestodes in Ethiopia. Parasitol Res, 112(1), 141-146. https://doi.org/10.1007/s00436-012-3117-1

Publication

Parasitology research
ISSN: 1432-1955
NlmUniqueID: 8703571
Country: Germany
Language: English
Volume: 112
Issue: 1
Pages: 141-146

Researcher Affiliations

Getachew, A M
  • Division of Animal Production and Public Health Comparative Epidemiology and Informatics Institute of Comparative Medicine, University of Glasgow, Veterinary School, Bearsden, Glasgow, G61 1QH, UK. m.getachew06@yahoo.co.uk
Innocent, G
    Proudman, C J
      Trawford, A
        Feseha, G
          Reid, S W J
            Faith, B
              Love, S

                MeSH Terms

                • Administration, Oral
                • Animals
                • Anthelmintics / administration & dosage
                • Antibodies, Helminth / blood
                • Cestoda / drug effects
                • Cestode Infections / drug therapy
                • Cestode Infections / veterinary
                • Equidae
                • Ethiopia
                • Feces / parasitology
                • Female
                • Ivermectin / administration & dosage
                • Male
                • Ointments / administration & dosage
                • Parasite Egg Count
                • Praziquantel / administration & dosage
                • Treatment Outcome

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                Citations

                This article has been cited 1 times.
                1. Buono F, Veneziano V, Veronesi F, Molento MB. Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections. Parasitology 2023 Oct;150(12):1119-1138.
                  doi: 10.1017/S0031182023000525pubmed: 37221816google scholar: lookup
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