Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horses.
Abstract: Respiratory inductance plethysmographic (RIP) and pneumotachographic (Pn) flows were compared dynamically in horses with bronchoconstriction. On a breath-by-breath basis, RIP was normalized to inspiratory volume from Pn, and peak [peak of subtracted final exhalation waveform (SFE(max))] and selected area [integral of subtracted final waveform during first 25% of exhaled volume (SFE(int))] differences between RIP and Pn flows during early expiration were measured in three settings: 1) healthy horses (n = 8) undergoing histamine bronchoprovocation; 2) horses with naturally occurring lower airway obstruction (AO) (n = 7); and 3) healthy horses (n = 6) given lobeline. HCl to induce hyperpnea. In setting 1, histamine challenge induced a dose-dependent increase in SFE(max) and SFE(int) differences. A test index of airway reactivity (interpolated histamine dose that increased SFE(max) by 35%) closely correlated (r(s) = 0.93, P = 0.001) with a conventional index (histamine dose that induced a 35% decrease in dynamic compliance). In setting 2, in horses with AO, SFE(max) and SFE(int) were markedly elevated, and their absolute values correlated significantly (P < 0.005) with pulmonary resistance and the maximum change in transpulmonary pressure. The effects of bronchodilator treatment on the SFE(max) and SFE(int) were also highly significant (P < 0.0001). In setting 3, hyperpnea, but not tachypnea, caused significant (P < 0.01) increases in SFE(max) but not in SFE(int). In conclusion, dynamic comparisons between RIP and Pn provide a defensible method for quantifying AO during tidal breathing, without the need for invasive instrumentation.
Publication Date: 2001-11-22 PubMed ID: 11717245DOI: 10.1152/jappl.2001.91.6.2767Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Asthma
- Biotechnology
- Bronchodilation
- Chronic Obstructive Pulmonary Disease
- Clinical Pathology
- Clinical Study
- Comparative Study
- Diagnosis
- Diagnostic Technique
- Disease Diagnosis
- Disease Treatment
- Equine Health
- Histamine
- Horses
- Noninvasive Procedures
- Pharmacology
- Physiology
- Respiratory Health
- Veterinary Medicine
- Veterinary Practice
- Veterinary Research
Summary
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This study explores and compares two methods—respiratory inductance plethysmography (RIP) and pneumotachography (Pn)—for measuring respiratory flow in horses with bronchoconstriction. The findings suggest that RIP provides a reliable technique for quantifying airway obstruction during tidal breathing, without the need for invasive procedures.
Research Methods and Materials
- The researchers utilized the techniques of respiratory inductance plethysmography (RIP) and pneumotachography (Pn) to measure and compare the respiratory flows in horses.
- The study was conducted in three different scenarios: healthy horses subjected to histamine bronchoprovocation, horses with naturally occurring airway obstruction, and healthy horses given lobeline HCl to induce hyperpnea.
- The researchers normalized RIP to the inspiratory volume obtained from Pn. Also, they examined the differences in the peak and selected area of RIP and Pn flows during early exhalation.
Research Findings
- In the first scenario, the researchers found that histamine challenge lead to a dose-dependent increase in the discrepancies in the peak and selected area of the RIP and Pn flows.
- The researchers developed an index to test airway reactivity. They found that the index significantly correlated with traditional indexes.
- In the second scenario, horses with airway obstruction depicted elevated difference values, which correlated significantly with pulmonary resistance and the peak change in transpulmonary pressure.
- The impact of bronchodilator treatment on the differences was also observed and found to be highly significant.
- In the third setting, researchers found that hyperpnea lead to significant changes in the peak difference, but not in the selected area difference.
Conclusions
- The study concludes that dynamic comparisons between RIP and Pn are reliable methods to quantify airway obstruction (AO) in horses during tidal breathing. This is significant as it provides a noninvasive procedure for evaluating and monitoring respiratory health in horses.
Cite This Article
APA
Hoffman A, Kuehn H, Riedelberger K, Kupcinskas R, Miskovic MB.
(2001).
Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horses.
J Appl Physiol (1985), 91(6), 2767-2775.
https://doi.org/10.1152/jappl.2001.91.6.2767 Publication
Researcher Affiliations
- Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA. andrew.hoffman@tufts.edu
MeSH Terms
- Airway Resistance
- Animals
- Bronchi / drug effects
- Bronchi / physiology
- Bronchi / physiopathology
- Bronchoconstriction
- Bronchodilator Agents / pharmacology
- Histamine / pharmacology
- Horses
- Lobeline
- Plethysmography / instrumentation
- Plethysmography / methods
- Pulmonary Ventilation
- Respiration Disorders / chemically induced
- Respiration Disorders / physiopathology
- Respiratory System Agents
- Rheology / instrumentation
- Vomiting / physiopathology
Citations
This article has been cited 8 times.- Chang T, Akin S, Kim MK, Murray L, Kim B, Cho S, Huh S, Teke S, Couetil L, Jun MB, Lee CH. A Programmable Dual-Regime Spray for Large-Scale and Custom-Designed Electronic Textiles. Adv Mater 2022 Mar;34(9):e2108021.
- Secombe C, Adler A, Hosgood G, Raisis A, Mosing M. Can bronchoconstriction and bronchodilatation in horses be detected using electrical impedance tomography?. J Vet Intern Med 2021 Jul;35(4):2035-2044.
- Dixon CE, Bedenice D, Mazan MR. Comparison of Flowmetric Plethysmography and Forced Oscillatory Mechanics to Measure Airway Hyperresponsiveness in Horses. Front Vet Sci 2020;7:511023.
- Lanz S, Brunner A, Graubner C, Marti E, Gerber V. Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity. J Vet Intern Med 2017 Nov;31(6):1877-1883.
- Burnheim K, Hughes KJ, Evans DL, Raidal SL. Reliability of breath by breath spirometry and relative flow-time indices for pulmonary function testing in horses. BMC Vet Res 2016 Nov 28;12(1):268.
- Pacheco AP, Paradis MR, Hoffman AM, Hermida P, Sanchez A, Nadeau JA, Tufts M, Mazan MR. Age effects on blood gas, spirometry, airway reactivity, and bronchoalveolar lavage fluid cytology in clinically healthy horses. J Vet Intern Med 2014 Mar-Apr;28(2):603-8.
- Onmaz AC, Stoklas-Schmidt C, van den Hoven R. Daily variability of forced oscillometry parameters in horses suffering recurrent airway obstruction, a pilot study. Vet Res Commun 2013 Mar;37(1):11-7.
- Robins TJ, Bedenice D, Mazan M. A Longitudinal Analysis of Equine Asthma Presentation and Response to Treatment Using Lung Function Testing and BAL Cytology Analysis in Combination with Owner Perception. Animals (Basel) 2023 Nov 1;13(21).
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