Flunixin meglumine blocks frusemide-induced bronchodilation in horses with chronic obstructive pulmonary disease.
Abstract: Six horses that developed acute airway obstruction (heaves) when housed in a barn and fed poor-quality hay were studied. Airway obstruction was verified by a maximal change in pleural pressure during tidal breathing (delta Pplmax) of at least 15 cmH2O. Frusemide (1.0 mg/kg bwt) or an equivalent volume of vehicle was then administered intravenously (iv) and lung function was measured 15, 30, 60, 120, 180, 240 and 300 mins after drug administration. The effect of frusemide on lung function was also studied after treatment of horses with the cyclooxygenase inhibitor flunixin meglumine (1.1 mg/kg every 8 h for 2 days before the experiment). Frusemide significantly reduced the delta Pplmax beginning 15 mins after drug administration. This effect persisted for 5 h. The reduction in delta Pplmax was due partly to an increase in dynamic compliance and partly to a decrease in pulmonary resistance. Tidal volume and respiratory frequency were unaffected by frusemide. Vehicle had no effect on lung function. Flunixin meglumine abolished the effect of frusemide on airway calibre but did not prevent diuresis. These results indicate that the effect of frusemide on airways of horses with heaves persists for at least 5 h, is mediated through prostanoids, and is not a result of diuresis.
Publication Date: 1993-03-01 PubMed ID: 8467773DOI: 10.1111/j.2042-3306.1993.tb02924.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Airway Disease
- Animal Health
- Bronchodilation
- Chronic Obstructive Pulmonary Disease
- Clinical Study
- Disease Treatment
- Diuresis
- Equine Health
- Flunixin Meglumine
- Furosemide
- Horses
- Lung Health
- Pharmacodynamics
- Pharmacology
- Pleural Pressure
- Prostaglandins
- Respiratory Disease
- Respiratory Health
- Veterinary Medicine
- Veterinary Research
Summary
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This study investigates the effect of flunixin meglumine, a drug, on the respiratory function of horses suffering from chronic obstructive pulmonary disease. It shows that the drug inhibits the bronchodilation effect of frusemide, another therapeutic agent, suggesting that prostanoids mediate the effect of frusemide.
Introduction
- This research focuses on six horses with severe respiratory issues, a condition classified as heaves, which were fed poor quality hay and housed in a barn.
- The study aimed to test the effect of two drugs on these horses’ lung functioning: frusemide and flunixin meglumine.
Methodology
- To confirm the presence of airway obstruction, a pleural pressure change of at least 15 cm H2O was checked during regular breathing (delta Pplmax).
- The horses were administered either frusemide or an equivalent amount of vehicle (a substance that does not have therapeutic effects, used in pharmacological research as a control).
- The lung function was measured at regular intervals after drug administration: 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, and 5 hours.
- The same frusemide testing was repeated after horses were treated with flunixin meglumine (a cyclooxygenase inhibitor that obstructs enzymes involved in inflammation).
Results
- Frusemide significantly decreased the delta Pplmax from the 15-minute mark, continuing for 5 hours.
- The decrease in delta Pplmax resulted from an increase in dynamic compliance (the lungs’ ability to expand) and a decrease in pulmonary resistance (the opposition to airflow in the lungs).
- Frusemide didn’t affect the tidal volume (the amount of air displaced during a normal breath) and respiratory frequency.
- The vehicle did not influence the lung function.
- Flunixin meglumine canceled the frusemide’s effect on the airway size without preventing diuresis (excessive urine production).
Conclusion
- The findings suggested that frusemide affects horses with heaves for at least five hours, mediated by prostanoids (lipid compounds that perform diverse functions in the body) and is not a diuresis result.
- Flunixin meglumine can block frusemide’s effect on the airways of horses with chronic obstructive pulmonary disease.
Cite This Article
APA
Rubie S, Robinson NE, Stoll M, Broadstone RV, Derksen FJ.
(1993).
Flunixin meglumine blocks frusemide-induced bronchodilation in horses with chronic obstructive pulmonary disease.
Equine Vet J, 25(2), 138-142.
https://doi.org/10.1111/j.2042-3306.1993.tb02924.x Publication
Researcher Affiliations
- Pulmonary Laboratory, College of Veterinary Medicine, Michigan State University, E. Lansing 48824.
MeSH Terms
- Analysis of Variance
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / pharmacology
- Bronchoconstriction / drug effects
- Clonixin / analogs & derivatives
- Clonixin / pharmacology
- Furosemide / antagonists & inhibitors
- Furosemide / pharmacology
- Furosemide / therapeutic use
- Horse Diseases / drug therapy
- Horse Diseases / physiopathology
- Horses
- Lung / drug effects
- Lung / physiopathology
- Lung Diseases, Obstructive / drug therapy
- Lung Diseases, Obstructive / physiopathology
- Lung Diseases, Obstructive / veterinary
- Respiration / drug effects
- Tidal Volume / drug effects
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