Free radicals and antioxidants in inflammatory processes and ischemia-reperfusion injury.
Abstract: This article discusses the current understanding of the role of free radicals and antioxidants in inflammatory processes and in ischemia reperfusion injury. It begins by describing the manifestations of acute inflammation and outlining the cellular events that occur during inflammation. It then describes the biochemical mediators of inflammation with special attention to nitric oxide. It details the process of hypoxia reperfusion injury, the enzymes involved, its treatment, and studies involving specific hypoxia reperfusion injuries in various animal species.
Publication Date: 2008-02-06 PubMed ID: 18249244DOI: 10.1016/j.cvsm.2007.11.008Google Scholar: Lookup
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Summary
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This research article delves into the interactions between free radicals and antioxidants in inflammation and ischemia-reperfusion injuries. It discusses the progression of acute inflammation and the involved cellular events along with the key biochemical mediators, focusing on nitric oxide. Furthermore, it outlines the hypoxia reperfusion injury process, involved enzymes, treatments, and studies on specific hypoxia reperfusion injuries in different animal species.
Understanding Inflammatory Processes and Ischemia Reperfusion Injury
In the early parts of the study, the research article attempts to elucidate the complexities of acute inflammation. This discussion includes:
- The various manifestations that define the presence of an acute inflammatory reaction.
- The different cellular events that occur during the progression of the inflammation.
Furthermore, it offers a comprehensive examination of the biochemical mediators responsible for instigating and sustaining the inflammatory process. Of these, the research points out:
- Nitric oxide as a crucial player, given its widely recognized roles in numerous physiological and pathological conditions.
Hypoxia Reperfusion Injury
On the subject of ischemia-reperfusion injury, the research then dives into:
- Understanding the phenomenon of hypoxia reperfusion injury, a condition that typically arises when blood supply returns to tissue after a period of ischemia, or lack of oxygen.
- Highlighting the molecular mechanisms and enzymes that play critical parts in orchestrating the injury process.
- Discussing plausible treatment options for managing ischemia-reperfusion injuries.
Animal Studies
In the concluding part of the study, the researchers shift the focus towards:
- Analyzing specific cases of hypoxia reperfusion injuries across different animal species.
- Using these studies to understand the typical molecular and histological alterations that take place during a hypoxia reperfusion injury.
Cite This Article
APA
Vajdovich P.
(2008).
Free radicals and antioxidants in inflammatory processes and ischemia-reperfusion injury.
Vet Clin North Am Small Anim Pract, 38(1), 31-v.
https://doi.org/10.1016/j.cvsm.2007.11.008 Publication
Researcher Affiliations
- Department of Internal Medicine and Clinics, Szent István University, H-1078, István u. 2., P.O. Box 1400, Budapest, Hungary. vajdovich.peter@aotk.szie.hu
MeSH Terms
- Animals
- Antioxidants / metabolism
- Cats
- Cattle
- Dogs
- Free Radicals / metabolism
- Horses
- Hypoxia
- Inflammation / metabolism
- Nitric Oxide / metabolism
- Oxidation-Reduction
- Oxidative Stress
- Reactive Oxygen Species / metabolism
- Reperfusion Injury / metabolism
- Species Specificity
Citations
This article has been cited 7 times.- Hosseini A, Stojkov D, Fettrelet T, Bilyy R, Yousefi S, Simon HU. Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases.. Int J Mol Sci 2023 Jan 31;24(3).
- Milech V, de Oliveira JS, de Ataide MAW, Coradini GP, Mann TR, Sarturi VZ, Hartmann HF, Linhares MT, Antunes BN, de Andrade CM, Kommers GD, Silva MAM, Müller DCM, Brun MV. Effects of Heated Pneumoperitoneum on Inflammation, Oxidative Stress, and Peritoneal Histology in Female Dogs That Underwent Video-Assisted Ovariohysterectomy.. Vet Med Int 2021;2021:5515559.
- Guo Z, Gao S, Ouyang J, Ma L, Bu D. Impacts of Heat Stress-Induced Oxidative Stress on the Milk Protein Biosynthesis of Dairy Cows.. Animals (Basel) 2021 Mar 7;11(3).
- de Boer RA, Costantini D, Casasole G, AbdElgawad H, Asard H, Eens M, Müller W. Sex-specific effects of inbreeding and early life conditions on the adult oxidative balance.. Curr Zool 2018 Oct;64(5):631-639.
- Cai YJ, Wang WS, Liang HY, Sun LH, Teitelbaum DH, Yang H. Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo.. Int J Clin Exp Pathol 2012;5(6):569-80.
- Hossain M, Mazzone P, Tierney W, Cucullo L. In vitro assessment of tobacco smoke toxicity at the BBB: do antioxidant supplements have a protective role?. BMC Neurosci 2011 Sep 24;12:92.
- Guan Y, Worrell RT, Pritts TA, Montrose MH. Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo.. Am J Physiol Gastrointest Liver Physiol 2009 Jul;297(1):G187-96.
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