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BMC research notes2016; 9(1); 405; doi: 10.1186/s13104-016-2201-5

Friesian horses as a possible model for human acquired aortopulmonary fistulation.

Abstract: Acquired aortopulmonary fistulation is a rare condition in humans. It usually results as a late complication of a true or pseudoaneurysm of the thoracic aorta. It is most commonly associated with trauma or surgery, less commonly with atherosclerosis, inflammation, hypertension or Marfan's syndrome. Aortopulmonary fistulation is also seen as a rare complication of acute aortic dissection. On rare occasions, acquired aortopulmonary fistulation is reported in aged patients without any of the above mentioned triggering factors. Thus, these cases should be considered as idiopathic aortopulmonary fistulation. Clearly, the pathogenesis of this condition is not yet completely understood. Friesian horses are highly inbred and are affected by several genetic conditions. Rupture of the thoracic aorta has a relatively high prevalence in Friesian horses and is often characterized by the formation of a pseudoaneurysm with subsequent fistulation into the pulmonary artery. Affected animals may survive for several weeks to months. Results: Here we performed vascular casting in three affected Friesian horses. In all three cases, an aortic rupture at the caudoventral side of the aorta was connected with a rupture of the main pulmonary artery just proximal to its bifurcation. Conclusions: Affected Friesians show a consistent location and configuration of the aortic rupture site, very similar to the human condition and therefore could act as a spontaneous model to study this disease.
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Publication Date: 2016-08-15 PubMed ID: 27527829PubMed Central: PMC4986238DOI: 10.1186/s13104-016-2201-5Google Scholar: Lookup
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Summary

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The researchers propose using Friesian horses as a model to study acquired aortopulmonary fistulation (a rare heart condition) in humans. This is because both humans and Friesian horses exhibit similar configurations of the condition, thus offering potential insights into its pathogenesis.

Objective of the Study

  • The primary aim of this study is to further understand the pathogenesis (the mechanism by which the disease is caused) of acquired aortopulmonary fistulation, a rare but severe heart condition affecting both humans and Friesian horses.

Background and Research Methodology

  • Acquired aortopulmonary fistulation, often associated with trauma, surgery, hypertension, and other triggering factors, has also been observed in idiopathic cases where no triggering factors are identified. Thus, this study seeks to comprehend the pathogenesis of the disease better.
  • Friesian horses are often affected by various genetic conditions, one of which is the rupture of the thoracic aorta, similar to the aortopulmonary fistulation seen in humans.
  • For this investigation, vascular casting was performed on three affected Friesian horses. The observation was that each case showed an aortic rupture connected to a rupture of the main pulmonary artery.

Findings and Conclusions

  • The results of the study showed that the location and configuration of the rupture in Friesian horses were consistent and strikingly similar to the cases of aortopulmonary fistulation in humans.
  • On this basis, the authors suggest that Friesian horses could potentially serve as a spontaneous model for this heart disease, allowing further studies and hopefully leading to enhanced understanding and treatment options for both humans and horses affected by aortopulmonary fistulation.

Cite This Article

APA
Saey V, Vandecasteele T, van Loon G, Cornillie P, Ploeg M, Delesalle C, Gröne A, Gielen I, Ducatelle R, Chiers K. (2016). Friesian horses as a possible model for human acquired aortopulmonary fistulation. BMC Res Notes, 9(1), 405. https://doi.org/10.1186/s13104-016-2201-5

Publication

BMC research notes
ISSN: 1756-0500
NlmUniqueID: 101462768
Country: England
Language: English
Volume: 9
Issue: 1
Pages: 405

Researcher Affiliations

Saey, V
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium. Veronique.saey@ugent.be.
Vandecasteele, T
  • Department of Morphology, Ghent University, Merelbeke, Belgium.
van Loon, G
  • Department of Large Animal Internal Medicine, Ghent University, Merelbeke, Belgium.
Cornillie, P
  • Department of Morphology, Ghent University, Merelbeke, Belgium.
Ploeg, M
  • Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Delesalle, C
  • Department of Comparative Physiology and Biometrics, Ghent University, Merelbeke, Belgium.
Gröne, A
  • Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Gielen, I
  • Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Ducatelle, R
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium.
Chiers, K
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium.

MeSH Terms

  • Animals
  • Aortic Rupture / diagnostic imaging
  • Aortic Rupture / physiopathology
  • Arterio-Arterial Fistula / diagnostic imaging
  • Arterio-Arterial Fistula / pathology
  • Arterio-Arterial Fistula / physiopathology
  • Coronary Circulation
  • Disease Models, Animal
  • Female
  • Horses
  • Humans
  • Male
  • Pulmonary Artery / abnormalities
  • Pulmonary Artery / diagnostic imaging
  • Pulmonary Artery / pathology
  • Pulmonary Artery / physiopathology
  • Ultrasonics

References

This article includes 42 references
  1. Boyd LJ. A study of four thousand reported cases of aneurysm of the thoracic aorta.. Am J Med Sci 1924;168:654–663.
    doi: 10.1097/00000441-192411000-00006google scholar: lookup
  2. Razzouk A, Gundry S, Wang N, Heyner R, Sciolaro C, Van Arsdell G, Bansal R, Vyhmeister E, Bailey L. Pseudoaneurysms of the aorta after cardiac surgery or chest trauma.. Am Surg 1993;59:818–823.
    pubmed: 8256935
  3. Kort S, Tunick PA, Applebaum RM, Hayes R, Krinsky GA, Sadler W. Acquired aortopulmonary artery fistula: diagnosis by multiple imaging modalities.. J Am Soc Echocardiogr 2001;14:842–845.
    doi: 10.1067/mje.2001.111937pubmed: 11490337google scholar: lookup
  4. Lahey SJ. Successful surgical management of an aortic arch aneurysm with acute aorto-pulmonary fistula.. Ann Thorac Surg 1993;55:995–997.
    doi: 10.1016/0003-4975(93)90134-4pubmed: 8466359google scholar: lookup
  5. Coselli S, LeMaire SA, van Gleve RD. Rupture of a dissecting thoracic aortic aneurysm into the pulmonary artery: successful surgical repair.. Cardiovasc Surg 1995;3:697–701.
    doi: 10.1016/0967-2109(96)82872-9pubmed: 8745196google scholar: lookup
  6. Atay Y, Can L, Yagdi Buket S. Aortopulmonary artery fistula. Presenting with congestive heart failure in a patient with aortic dissection.. Tex Heart Inst J 1998;25:72–74.
    pmc: PMC325506pubmed: 9566068
  7. Rooney JR, Prickett ME, Crowe MW. Aortic ring rupture in stallions.. Pathol Vet 1967;4:268–274.
    pubmed: 5624872
  8. Brown CM, Kaneene JB, Taylor RF. Sudden and unexpected death in horses and ponies: an analysis of 200 cases.. Equine Vet J 1988;20:99–103.
    doi: 10.1111/j.2042-3306.1988.tb01468.xpubmed: 3371329google scholar: lookup
  9. Ploeg M, Saey V, de Bruijn CM, Grone A, Chiers K, van Loon G, Ducatelle R, van Weeren PR, Back W, Delesalle C. Aortic rupture and aorto-pulmonary fistulation in the Friesian horse: characterisation of the clinical and gross post mortem findings in 24 cases.. Equine Vet J 2013;45:101–106.
    doi: 10.1111/j.2042-3306.2012.00580.xpubmed: 22607232google scholar: lookup
  10. Ploeg M, Saey V, Delesalle C, Grone A, Ducatelle R, de Bruijn CM, Back W, van Weeren PR, van Loon G, Chiers K. Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse: histomorphologic characterization.. Vet Pathol 2015;52:152–159.
    doi: 10.1177/0300985814528219pubmed: 24741028google scholar: lookup
  11. Bankl H. Congenital malformations of the heart and great vessels: synopsis of pathology, embryology and natural history.. Baltimore: Urban and Schwarzenberg; 1977. pp. 151–155.
  12. van Loon G, De Clercq D, De Bruijn CM, Decloedt A, Verheyen T, Saey V, Ducatelle R, Chiers K, Ploeg M, Back W, Delesalle C, Deprez P. Aortic rupture and aortopulmonary fistulation: increased prevalence in Friesian horses and importance of early ante-mortem diagnosis.. Conference Abstract Association Vétérinaire Equine Française (AVEF) 2011.
  13. De Bruijn CM, van Loon G, Ploeg M, Gröne A, De Clercq D, Decloedt A, Van Weeren PR, Back W, Delesalle C. Use of transoesophageal ultrasound to visualise the aortopulmonary region in two normal friesian horses and three friesians with aortic rupture or aortopulmonary fistulation.. Equine Vet J 2013;45:11–12.
    doi: 10.1111/evj.12145_28google scholar: lookup
  14. Vandecasteele T, Vandevelde K, Doom M, Van Mulken E, Simoens P, Cornillie P. The pulmonary veins of the pig as an anatomical model for the development of a new treatment for atrial fibrillation.. Anat Histol Embryol 2015;44:1–12.
    doi: 10.1111/ahe.12099pubmed: 24372538google scholar: lookup
  15. Rajiah P. CT and MRI in the evaluation of thoracic aortic diseases.. Int J Vasc Med 2013.
    pmc: PMC3874367pubmed: 24396601
  16. Thompson RW, Geraghty PJ, Lee JK. Abdominal aortic aneurysms: basic mechanisms and clinical implications.. Curr Probl Surg 2002;39:110–230.
    doi: 10.1067/msg.2002.121421pubmed: 11884965google scholar: lookup
  17. Jain D, Dietz HC, Oswald GL, Maleszewski JJ, Halushka MK. Causes and histopathology of ascending aortic disease in children and young adults.. Cardiovasc Pathol 2011;20:15–25.
    doi: 10.1016/j.carpath.2009.09.008pmc: PMC3046386pubmed: 19926309google scholar: lookup
  18. Reed D, Reed C, Stemmermann G, Hayashi T. Are aortic aneurysms caused by atherosclerosis?. Circulation 1992;85:205–211.
    doi: 10.1161/01.CIR.85.1.205pubmed: 1728451google scholar: lookup
  19. Elefteriades JA. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks.. Ann Thorac Surg 2002;74:1877–1880.
    doi: 10.1016/S0003-4975(02)04147-4pubmed: 12440685google scholar: lookup
  20. Nzewi O, Slight RD, Zamvar V. Management of blunt thoracic aortic injury.. Eur J Vasc Endovasc Surg 2006;31:18–27.
    doi: 10.1016/j.ejvs.2005.06.031pubmed: 16226902google scholar: lookup
  21. Gleason TG, Bavaria JE. Trauma to great vessels.. In: Cohn LH, Edmunds LHJ, editors. Cardiac surgery in the adult. New York: McGraw-Hill; 2003. pp. 1229–1250.
  22. Pearson R, Philips N, Hancock R, Hashim S, Field M, Richens D, McNally D. Regional wall mechanics and blunt traumatic aortic rupture at the isthmus.. Eur J Cardiothorac Surg 2008;34:616–622.
    doi: 10.1016/j.ejcts.2008.03.069pubmed: 18515136google scholar: lookup
  23. Katsumata T, Shinfeld A, Westaby S. Operation for chronic traumatic aortic aneurysm: when and how?. Ann Thorac Surg 1998;66:774–778.
    doi: 10.1016/S0003-4975(98)00519-0pubmed: 9768929google scholar: lookup
  24. Giglioli C, Cecchi E, Angelotti P, Venditti F, Calabretta R, Scheggi V, Alterini B, Stefano P. Aortopulmonary fistula presenting with right ventricular dysfunction following blunt chest trauma.. J Card Surg 2013;28:713.
    doi: 10.1111/jocs.12212pubmed: 24118078google scholar: lookup
  25. Bol A, Missault L, Dossche KM, Delanote J. Aortopulmonary artery fistula in atherosclerotic pseudoaneurysm presenting with congestive heart failure after aortic valve replacement.. Acta Chir Belg 2006;106:240–242.
    doi: 10.1080/00015458.2006.11679882pubmed: 16761489google scholar: lookup
  26. Drake RL, Vogl WA, Mitchell AWM. Gray’s anatomy for students.. 2. Churchill Livingstone: Elsevier; 2010.
  27. Sisson S, Grossman JD. The anatomy of domestic animals.. 3. Philadelphia: WB Saunders; 1938.
  28. Casteleyn C, Cornillie P, Simoens P. Anatomie comparée de l’arc aortique de l’homme, des animaux domestiques et des animaux de laboratoire: à la recherche d’un modèle, pour faciliter l’étude des maladies vasculaires humaines.. STAL 2010;36:41–45.
  29. Massetti M, Babatasi G, Rossi A, Kapadia N, Neri E, Bhoyroo S, Gerard JL, Commeau P, Khayat A. Aortopulmonary fistula: an uncommon complication in dystrophic aortic aneurysm.. Ann Thorac Surg 1995;59:1563–1564.
    doi: 10.1016/0003-4975(95)00032-Gpubmed: 7771843google scholar: lookup
  30. Bauer M, Siniawski H, Pasic M, Schaumann B, Hetzer R. Different hemodynamic stress of the ascending aorta wall in patients with bicuspid and tricuspid aortic valve.. J Card Surg 2006;21:218–220.
    doi: 10.1111/j.1540-8191.2006.00219.xpubmed: 16684044google scholar: lookup
  31. Machida N, Yasuda J, Too K, Kudo N. A morphological study on the obliteration processes of the ductus arteriosus in the horse.. Equine Vet J 1988;20(4):249–254.
    doi: 10.1111/j.2042-3306.1988.tb01516.xpubmed: 3168984google scholar: lookup
  32. Guarda I, Schifferli CA, Alvarez LH, Probst A, König HE. Ductus arteriosus persistens bei einem fohl.. Vet Med Austria 2005;92:233–237.
  33. Saey V, Ploeg M, Delesalle C, van Loon G, Gröne A, Ducatelle R, Duchateau L, Chiers K. Morphometric properties of the thoracic aorta of warmblood and Friesian horses with and without aortic rupture.. J Comp Pathol 2016;154(2–3):225–230.
    doi: 10.1016/j.jcpa.2016.02.001pubmed: 26987511google scholar: lookup
  34. Saey V, Famaey N, Smoljkic M, Claeys E, van Loon G, Ducatelle R, Ploeg M, Delesalle C, Grone A, Duchateau L, Chiers K. Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture.. BMC Vet Res 2015;11:285.
    doi: 10.1186/s12917-015-0597-0pmc: PMC4652382pubmed: 26581331google scholar: lookup
  35. Hope MD, Hope TA, Urbania TH, Higgins CB. Four-dimensional flow magnetic resonance imaging with wall shear stress analysis before and after repair of aortopulmonary fistula.. Circ Cardiovasc Imaging 2010;3:766–768.
    doi: 10.1161/CIRCIMAGING.110.957712pubmed: 21081744google scholar: lookup
  36. Hampson S, Pepper J. Aortopulmonary fistula: role of computed tomography.. Thorax 1987;42:395–396.
    doi: 10.1136/thx.42.5.395pmc: PMC460764pubmed: 3660295google scholar: lookup
  37. Sabety AM, Gerard FP. Aorto-pulmonary fistula: report of a case.. Chest J 1966;50:649–651.
    pubmed: 5964874
  38. Ahmadi ZH, Ansari AZ, Saghebi SR, Kianfar AA, Hashemian SM, Kahkouee S, Naderi H. Massive hemoptysis, a presentation of invasion of aneurysm of descending aorta to bronchopulmonary tree.. Arch Iran Med 2014;17:786–788.
    pubmed: 25365623
  39. van Loon G, Verheyen T, Decloedt A, Delesalle C, Schauvliege S, De Wolf D. Use of a transcatheter occlusion device in a 9-year old Friesian gelding with aortopulmonary fistula.. Eur Vet Conf. Voorjaarsdagen 2011:365.
  40. Killen DA, Muehlebach GF, Wathanacharoen S. Aortopulmonary fistula.. South Med J 2000;93:195–198.
    doi: 10.1097/00007611-200002000-00008pubmed: 10701787google scholar: lookup
  41. Belgi A, Altekin E, Yalcinkaya S, Tuzuner FE. Acquired aorto-pulmonary fistula: a case of ruptured aneurysm of the thoracic aorta.. Anadolu Kardiyol Derg 2003;3:275–278.
    pubmed: 12967899
  42. Dixit MD, Gan M, Narendra NG, Mohapatra RL, Halkatti PC, Bhaskar BV. Aortopulmonary fistula: a rare complication of an aortic aneurysm.. Tex Heart Inst J 2009;36:483–485.
    pmc: PMC2763467pubmed: 19876436

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