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Home / Equine Research Bank / BMC Res Notes / Friesian horses as a possible model for human acquired aorto...
BMC research notes2016; 9(1); 405; doi: 10.1186/s13104-016-2201-5

Friesian horses as a possible model for human acquired aortopulmonary fistulation.

Abstract: Acquired aortopulmonary fistulation is a rare condition in humans. It usually results as a late complication of a true or pseudoaneurysm of the thoracic aorta. It is most commonly associated with trauma or surgery, less commonly with atherosclerosis, inflammation, hypertension or Marfan's syndrome. Aortopulmonary fistulation is also seen as a rare complication of acute aortic dissection. On rare occasions, acquired aortopulmonary fistulation is reported in aged patients without any of the above mentioned triggering factors. Thus, these cases should be considered as idiopathic aortopulmonary fistulation. Clearly, the pathogenesis of this condition is not yet completely understood. Friesian horses are highly inbred and are affected by several genetic conditions. Rupture of the thoracic aorta has a relatively high prevalence in Friesian horses and is often characterized by the formation of a pseudoaneurysm with subsequent fistulation into the pulmonary artery. Affected animals may survive for several weeks to months. Results: Here we performed vascular casting in three affected Friesian horses. In all three cases, an aortic rupture at the caudoventral side of the aorta was connected with a rupture of the main pulmonary artery just proximal to its bifurcation. Conclusions: Affected Friesians show a consistent location and configuration of the aortic rupture site, very similar to the human condition and therefore could act as a spontaneous model to study this disease.
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Publication Date: 2016-08-15 PubMed ID: 27527829PubMed Central: PMC4986238DOI: 10.1186/s13104-016-2201-5Google Scholar: Lookup
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Summary

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The researchers propose using Friesian horses as a model to study acquired aortopulmonary fistulation (a rare heart condition) in humans. This is because both humans and Friesian horses exhibit similar configurations of the condition, thus offering potential insights into its pathogenesis.

Objective of the Study

  • The primary aim of this study is to further understand the pathogenesis (the mechanism by which the disease is caused) of acquired aortopulmonary fistulation, a rare but severe heart condition affecting both humans and Friesian horses.

Background and Research Methodology

  • Acquired aortopulmonary fistulation, often associated with trauma, surgery, hypertension, and other triggering factors, has also been observed in idiopathic cases where no triggering factors are identified. Thus, this study seeks to comprehend the pathogenesis of the disease better.
  • Friesian horses are often affected by various genetic conditions, one of which is the rupture of the thoracic aorta, similar to the aortopulmonary fistulation seen in humans.
  • For this investigation, vascular casting was performed on three affected Friesian horses. The observation was that each case showed an aortic rupture connected to a rupture of the main pulmonary artery.

Findings and Conclusions

  • The results of the study showed that the location and configuration of the rupture in Friesian horses were consistent and strikingly similar to the cases of aortopulmonary fistulation in humans.
  • On this basis, the authors suggest that Friesian horses could potentially serve as a spontaneous model for this heart disease, allowing further studies and hopefully leading to enhanced understanding and treatment options for both humans and horses affected by aortopulmonary fistulation.

Cite This Article

APA
Saey V, Vandecasteele T, van Loon G, Cornillie P, Ploeg M, Delesalle C, Gröne A, Gielen I, Ducatelle R, Chiers K. (2016). Friesian horses as a possible model for human acquired aortopulmonary fistulation. BMC Res Notes, 9(1), 405. https://doi.org/10.1186/s13104-016-2201-5

Publication

BMC research notes
ISSN: 1756-0500
NlmUniqueID: 101462768
Country: England
Language: English
Volume: 9
Issue: 1
Pages: 405

Researcher Affiliations

Saey, V
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium. Veronique.saey@ugent.be.
Vandecasteele, T
  • Department of Morphology, Ghent University, Merelbeke, Belgium.
van Loon, G
  • Department of Large Animal Internal Medicine, Ghent University, Merelbeke, Belgium.
Cornillie, P
  • Department of Morphology, Ghent University, Merelbeke, Belgium.
Ploeg, M
  • Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Delesalle, C
  • Department of Comparative Physiology and Biometrics, Ghent University, Merelbeke, Belgium.
Gröne, A
  • Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Gielen, I
  • Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Ducatelle, R
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium.
Chiers, K
  • Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Merelbeke, Belgium.

MeSH Terms

  • Animals
  • Aortic Rupture / diagnostic imaging
  • Aortic Rupture / physiopathology
  • Arterio-Arterial Fistula / diagnostic imaging
  • Arterio-Arterial Fistula / pathology
  • Arterio-Arterial Fistula / physiopathology
  • Coronary Circulation
  • Disease Models, Animal
  • Female
  • Horses
  • Humans
  • Male
  • Pulmonary Artery / abnormalities
  • Pulmonary Artery / diagnostic imaging
  • Pulmonary Artery / pathology
  • Pulmonary Artery / physiopathology
  • Ultrasonics

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