Fueling equine performance: importance of mitochondrial phenotype in equine athletes.

1. Bechtel P, Kline K. Muscle fiber type changes in the middle gluteal of quarter and Standardbred horses from birth through one year of age. Comp. Exerc. Physiol. 2:265–270.
2. Bryan K, McGivney BA, Farries G, McGettigan PA, McGivney CL, Gough KF, MacHugh DE, Katz LM, Hill EW. Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components.. BMC Genomics 2017 Aug 9;18(1):595.
   doi: 10.1186/s12864-017-4007-9pmc: PMC5551008pubmed: 28793853google scholar: lookup
3. Davis M, Fulton M, Popken A. Effect of hyperthermia and acidosis on equine skeletal muscle mitochondrial oxygen consumption. Comp. Exerc. Physiol. 17(2):171–179.
   doi: 10.3920/CEP200041google scholar: lookup
4. Galisteo AM, Agiüera E, Monterde JG, Miró F. Gluteus medius muscle fiber type composition in Young Andalusian and Arabian Horses. J. Equine Vet. Sci. 12(4):254–258.
   doi: 10.1016/S0737-0806(06)81459-0google scholar: lookup
5. Glancy B, Hartnell LM, Malide D, Yu ZX, Combs CA, Connelly PS, Subramaniam S, Balaban RS. Mitochondrial reticulum for cellular energy distribution in muscle.. Nature 2015 Jul 30;523(7562):617-20.
   doi: 10.1038/nature14614pmc: PMC6988728pubmed: 26223627google scholar: lookup
6. Gnaiger E. Polarographic oxygen sensors, the oxygraph, and high-resolution respirometry to assess mitochondrial function. In: Dykens JA, Will Y, editors. Drug-induced mitochondrial dysfunction. Mitochondr Physiol Network, Innsbruck. p. 325–352.
7. Gnaiger E. Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. Mitochondrial Physiol Network 19.12. Innsbruck: OROBOROS MiPNet Publications.
8. Guy CP, Latham CM, Owen RN, Fowler AL, White-Springer SH. 107 Skeletal muscle mitochondrial parameters correlate with sales price in weanling racing-bred Thoroughbred horses. J. Anim. Sci. 98(Supplement_4):86.
   doi: 10.1093/jas/skaa278.157google scholar: lookup
9. Guy CP, Latham CM, Owen RN, Fowler AL, White-Springer SH. 108 President Oral Presentation Pick: select skeletal muscle mitochondrial measures in Thoroughbred weanlings are related to race earnings and sire. J. Anim. Sci. 98(Supplement_4):85.
   doi: 10.1093/jas/skaa278.155google scholar: lookup
10. Henry ML, Velez-Irizarry D, Pagan JD, Sordillo L, Gandy J, Valberg SJ. The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses.. Antioxidants (Basel) 2021 Oct 30;10(11).
    doi: 10.3390/antiox10111739pmc: PMC8615093pubmed: 34829610google scholar: lookup
11. Laner V, Boushel R, Hamilton K, Miller B, Williamson K, Davis M, Gnaiger E. Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibres. Mitochondr. Physiol. Network 19.13.
12. Larsen S, Nielsen J, Hansen CN, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel R, Helge JW, Dela F, Hey-Mogensen M. Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects.. J Physiol 2012 Jul 15;590(14):3349-60.
    doi: 10.1113/jphysiol.2012.230185pmc: PMC3459047pubmed: 22586215google scholar: lookup
13. Latham CM, Dickson EC, Owen RN, Larson CK, White-Springer SH. Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training.. Sci Rep 2021 Apr 1;11(1):7352.
    doi: 10.1038/s41598-021-86478-7pmc: PMC8016935pubmed: 33795725google scholar: lookup
14. Latham CM, Fenger CK, White SH. Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses.. J Anim Sci 2019 Jun 17;.
    doi: 10.1093/jas/skz203pubmed: 31211376google scholar: lookup
15. Lindholm A, Essén-Gustavsson B, McMiken D, Persson S, Thornton J. Muscle histochemistry and biochemistry of Thoroughbred horses during growth and training. Equine Exerc. Physiol. 7:211–217.
16. López-Rivero JL, Agüera E, Monterde JG, Rodríguez-Barbudo MV, Miró F. Comparative study of muscle fiber type composition in the middle gluteal muscle of Andalusian, Thoroughbred and Arabian horses. J. Equine Vet. Sci. 9(6):337–340.
    doi: 10.1016/S0737-0806(89)80072-3google scholar: lookup
17. López-Rivero JL, Agüera E, Rodríguez-Barbudo MV, Galisteo AM, Morales-López JL. Degree of correspondence between contractile and oxidative capacities in horse muscle fibres: a histochemical study.. Histol Histopathol 1990 Jan;5(1):49-53.
    pubmed: 2151981
18. Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C. Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis.. Acta Physiol (Oxf) 2018 Jan;222(1).
    doi: 10.1111/apha.12905pubmed: 28580772google scholar: lookup
19. Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M. Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race.. PLoS One 2017;12(4):e0174874.
    doi: 10.1371/journal.pone.0174874pmc: PMC5405936pubmed: 28445477google scholar: lookup
20. Mrugala D, Leatherwood JL, Morris EF, Dickson EC, Latham CM, Owen RN, Beverly MM, Kelley SF, White-Springer SH. Dietary conjugated linoleic acid supplementation alters skeletal muscle mitochondria and antioxidant status in young horses.. J Anim Sci 2021 Feb 1;99(2).
    doi: 10.1093/jas/skab037pmc: PMC7918170pubmed: 33539534google scholar: lookup
21. Niess AM, Simon P. Response and adaptation of skeletal muscle to exercise--the role of reactive oxygen species.. Front Biosci 2007 Sep 1;12:4826-38.
    doi: 10.2741/2431pubmed: 17569613google scholar: lookup
22. Owen RN. Effects of decreased dietary vitamin E plus a proprietary antioxidant blend on mitochondria in young performance horses [M.S. thesis]. College Station (TX): Texas A&M University.
23. Rivero JL, Ruz A, Martí-Korff S, Estepa JC, Aguilera-Tejero E, Werkman J, Sobotta M, Lindner A. Effects of intensity and duration of exercise on muscular responses to training of thoroughbred racehorses.. J Appl Physiol (1985) 2007 May;102(5):1871-82.
    doi: 10.1152/japplphysiol.01093.2006pubmed: 17255370google scholar: lookup
24. Rivero JL, Serrano AL, Henckel P, Agüera E. Muscle fiber type composition and fiber size in successfully and unsuccessfully endurance-raced horses.. J Appl Physiol (1985) 1993 Oct;75(4):1758-66.
    doi: 10.1152/jappl.1993.75.4.1758pubmed: 8282629google scholar: lookup
25. Rivero JL, Talmadge RJ, Edgerton VR. Correlation between myofibrillar ATPase activity and myosin heavy chain composition in equine skeletal muscle and the influence of training.. Anat Rec 1996 Oct;246(2):195-207.
    doi: 10.1002/(sici)1097-0185(199610)246:2<195::Aid-ar6>3.0.Co;2-0pubmed: 8888961google scholar: lookup
26. Stull CL, Albert WW. Comparison of muscle fiber types from 2-year-old fillies of the Belgian, Standardbred, Thoroughbred, Quarter horse and Welsh breeds.. J Anim Sci 1980 Aug;51(2):340-3.
    doi: 10.2527/jas1980.512340xpubmed: 7440432google scholar: lookup
27. Votion DM, Fraipont A, Goachet AG, Robert C, van Erck E, Amory H, Ceusters J, de la Rebière de Pouyade G, Franck T, Mouithys-Mickalad A, Niesten A, Serteyn D. Alterations in mitochondrial respiratory function in response to endurance training and endurance racing.. Equine Vet J Suppl 2010 Nov;(38):268-74.
    doi: 10.1111/j.2042-3306.2010.00271.xpubmed: 21059017google scholar: lookup
28. Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D. Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle.. PLoS One 2012;7(4):e34890.
    doi: 10.1371/journal.pone.0034890pmc: PMC3329552pubmed: 22529950google scholar: lookup
29. Wesolowski LT, Guy CP, Simons JL, Pagan JD, White-Springer SH. Race training improves skeletal muscle mitochondrial volume density, function, and capacity in Thoroughbreds. J. Equine Vet. Sci. 100:103488.
    doi: 10.1016/j.jevs.2021.103488google scholar: lookup
30. White SH, Warren LK, Li C, Wohlgemuth SE. Submaximal exercise training improves mitochondrial efficiency in the gluteus medius but not in the triceps brachii of young equine athletes.. Sci Rep 2017 Oct 30;7(1):14389.
    doi: 10.1038/s41598-017-14691-4pmc: PMC5662757pubmed: 29085004google scholar: lookup
31. White SH, Wohlgemuth S, Li C, Warren LK. Rapid Communication: Dietary selenium improves skeletal muscle mitochondrial biogenesis in young equine athletes.. J Anim Sci 2017 Sep;95(9):4078-4084.
    doi: 10.2527/jas2017.1919pubmed: 28992020google scholar: lookup
32. Wood CH, Ross TT, Armstrong JB, Hall DC. Variations in muscle fiber composition between successfully and unsuccessfully raced Quarter Horses. J. Equine Vet. Sci. 8(3):217–220.
    doi: 10.1016/S0737-0806(88)80007-8google scholar: lookup

Citations

1. Wesolowski LT, Semanchik PL, White-Springer SH. Beyond antioxidants: Selenium and skeletal muscle mitochondria. Front Vet Sci 2022;9:1011159.
   doi: 10.3389/fvets.2022.1011159pubmed: 36532343google scholar: lookup
2. Sælen-Helgesson S, Hafstad AD, Lund T, Nymo IH, Ciccone C, Wood SH, Folkow LP, Sundset MA. Effects of endurance training on skeletal muscle mitochondrial respiration in Siberian huskies and Alaskan huskies. Physiol Rep 2026 Jan;14(2):e70725.
   doi: 10.14814/phy2.70725pubmed: 41555628google scholar: lookup
3. Zhang L, Li H, Wang T, Chen C. Influence of upper-body high-intensity intermittent training on energy metabolism and maximal oxygen uptake in elite swimmers. Front Physiol 2025;16:1636405.
   doi: 10.3389/fphys.2025.1636405pubmed: 41030318google scholar: lookup
4. Wang T, Meng J, Peng X, Huang J, Huang Y, Yuan X, Li X, Yang X, Chang X, Zeng Y, Yao X. Metabolomics analysis and mRNA/miRNA profiling reveal potential cardiac regulatory mechanisms in Yili racehorses under different training regimens. PLoS One 2025;20(7):e0322468.
   doi: 10.1371/journal.pone.0322468pubmed: 40658689google scholar: lookup
5. Wei P, Sun W, Hao S, Deng L, Zou W, Wu H, Lu W, He Y. Dietary Supplementation of Crossbred Pigs with Glycerol, Vitamin C, and Niacinamide Alters the Composition of Gut Flora and Gut Flora-Derived Metabolites. Animals (Basel) 2024 Jul 28;14(15).
   doi: 10.3390/ani14152198pubmed: 39123724google scholar: lookup
6. . importance of mitochondrial phenotype in equine athletes. Anim Front 2022 Jun;12(3):5.
   doi: 10.1093/af/vfac032pubmed: 35711508google scholar: lookup