Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).
Abstract: The activity of three anthelmintics (fenbendazole-FBZ; oxibendazole-OBZ; and pyrantel pamoate-PRT) was ascertained against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010) in field tests. A total of 316 foals were treated, and 168 (53.2%) were passing ascarid eggs on the day of treatment. Evaluation of drug efficacy was determined qualitatively by comparing the number of foals passing ascarid eggs in their feces before and after treatment. The main purpose was to obtain data on current activity of these compounds against ascarids. Additionally, the objective was to compare these findings with those from earlier data on the efficacy of these three compounds on nematodes in foals in this geographical area. Efficacies (average) for the foals ranged for FBZ (10 mg/kg) from 50% to 100% (80%), for OBZ (10 mg/kg) from 75% to 100% (97%), and for PRT at 1× (6.6 mg base/kg) from 0% to 71% (2%) and at 2× (13.2 mg base/kg) 0% to 0% (0%). Although the efficacy varied among the drugs, combined data for all farms indicated a significant reduction of ascarid infections for FBZ (p < 0.0001) and OBZ (p < 0.0001) but not for PRT (p = 0.0953).
Publication Date: 2011-04-16 PubMed ID: 21499750DOI: 10.1007/s00436-011-2379-3Google Scholar: Lookup
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Summary
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This research investigated the effectiveness of three anti-parasitic drugs against a horse parasite. The study found that fenbendazole and oxibendazole were significantly effective, but pyrantel pamoate showed limited effectiveness.
Research Overview
- The research study focuses on the effectiveness of three anthelmintic drugs – fenbendazole (FBZ), oxibendazole (OBZ), and pyrantel pamoate (PRT) – in the treatment of horse foals infested with the ascarid parasite Parascaris equorum (horse roundworm).
- The study was conducted on eight farms in Central Kentucky between 2009 and 2010.
- The purpose of the research was to gather current data on the effectiveness of these drugs against ascarid infections and to compare this data with older studies that evaluated the same drugs against nematodes in foals within the same geographical location.
Methodology and Sample
- A total of 316 foals were included in the study, out of which 168 (53.2%) were found to pass ascarid eggs in their feces on the day of treatment, indicating an active infection.
- The efficacy of the drugs were determined by comparing the number of foals passing ascarid eggs in their feces before and after treatment.
Key Findings
- The research found varying levels of effectiveness between the three drugs. FBZ showed an average effectiveness of 80% with a range of 50-100%, OBZ showed an average effectiveness of 97% with a range of 75-100%, and PRT showed limited effectiveness with an average efficacy of 2% at 1x dosage and 0% at 2x dosage.
- The collected data across all farms showed a significant reduction in ascarid infections with the use of FBZ (p<0.0001) and OBZ (p<0.0001). However, the use of PRT did not result in a significant reduction in ascarid infections with a p-value of 0.0953.
Conclusion
- The study concluded that FBZ and OBZ showed significant efficacy against ascarid infection in horse foals, making them suitable for treatment. However, PRT showed limited effectiveness and hence may not be a suitable choice of treatment against this specific type of parasite.
Cite This Article
APA
Lyons ET, Tolliver SC, Kuzmina TA, Collins SS.
(2011).
Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).
Parasitol Res, 109(4), 1193-1197.
https://doi.org/10.1007/s00436-011-2379-3 Publication
Researcher Affiliations
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. elyons1@uky.edu
MeSH Terms
- Animals
- Animals, Suckling
- Anthelmintics / pharmacology
- Anthelmintics / therapeutic use
- Ascaridida Infections / drug therapy
- Ascaridida Infections / epidemiology
- Ascaridida Infections / parasitology
- Ascaridida Infections / veterinary
- Ascaridoidea / drug effects
- Ascaridoidea / physiology
- Benzimidazoles / pharmacology
- Benzimidazoles / therapeutic use
- Feces
- Fenbendazole / pharmacology
- Fenbendazole / therapeutic use
- Horse Diseases / drug therapy
- Horse Diseases / epidemiology
- Horse Diseases / parasitology
- Horses
- Kentucky
- Parasite Egg Count / veterinary
- Pyrantel Pamoate / pharmacology
- Pyrantel Pamoate / therapeutic use
- Treatment Outcome
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