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Home / Equine Research Bank / Vet Med (Auckl) / Gammaherpesvirus infections in equids: a review.
Veterinary medicine (Auckland, N.Z.)2015; 6; 91-101; doi: 10.2147/VMRR.S39473

Gammaherpesvirus infections in equids: a review.

Abstract: Although the first equine gammaherpesvirus was identified over 50 years ago, the isolation and characterization of other members of this virus group has been relatively recent. Even so, numerous clinical syndromes have been identified in equid species in association with these viruses. Equid gammaherpesviruses are a genetically heterogeneous viral subfamily, the function of which in host immune modulation and disease pathogenesis has not yet been elucidated. While they share similarities with gammaherpesviruses in humans, the role they play in their relationship with the host is the subject of continued interest and research. Their widespread presence in horses and other equid species provides a considerable challenge in linking them with particular clinical and pathological conditions and in defining their significance from a diagnostic and therapeutic viewpoint. The present review provides an update on the taxonomy, epidemiology, and clinical syndromes, especially respiratory, reported in association with gammaherpesvirus infection in horses, donkeys, and other equid species.
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Publication Date: 2015-04-01 PubMed ID: 30155436PubMed Central: PMC6065615DOI: 10.2147/VMRR.S39473Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research reviews the understanding and impact of gammaherpesvirus infections in equids, such as horses and donkeys, with a focus on respiratory conditions. Despite their discovery over 50 years ago, the full understanding of these viruses, their interactions with host immune systems and role in disease pathogenesis, is not yet clear.

Introduction to Gammaherpesviruses in Equids

  • The gammaherpesviruses represent a group of viruses that have been identified in many equid species, including horses and donkeys. These viruses are known for their genetic diversity and complexity, potentially playing a significant role in the modulation of host immune responses and the development of diseases in infected animals.
  • Even though these viruses have been known for over five decades, it is only relatively recently that the isolation and characterization have taken place. This has broadened our understanding; however, there is still much that is unknown about these viral agents.

The Role of Gammaherpesviruses

  • Despite the existence of gammaherpesvirus in equids for a significant amount of time, their exact function and relation with the host is a renewed focal point for research.
  • Some similarities can be seen between gammaherpesviruses in equids and those in humans. Exploring these similarities further may provide insights into their biology and potential role in disease.

Challenges Presented by Gammaherpesviruses

  • Due to their extensive presence in equid species, it is difficult to precisely attribute specific clinical or pathological conditions to gammaherpesvirus infections.
  • This broad presence of the virus also complicates the efforts to understand its true significance for both diagnosis and treatment perspectives. As a consequence, more research is necessary to uncover the exact relationship between the viral infections, the host symptoms, and the causative pathological conditions.

Overview of the Research Review

  • The current paper aims to provide an updated review of various aspects of gammaherpesvirus infections in equid species. This includes an update on the current taxonomy, epidemiology, and related clinical syndromes.
  • The focus is especially on respiratory conditions, which are frequently associated with gammaherpesvirus infections in equids. Alongside, the review also includes information on some of the other diseases and conditions that have been reported in connection with these viruses.

Cite This Article

APA
Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. (2015). Gammaherpesvirus infections in equids: a review. Vet Med (Auckl), 6, 91-101. https://doi.org/10.2147/VMRR.S39473

Publication

Veterinary medicine (Auckland, N.Z.)
ISSN: 2230-2034
NlmUniqueID: 101724251
Country: New Zealand
Language: English
Volume: 6
Pages: 91-101

Researcher Affiliations

Marenzoni, Maria Luisa
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy, marialuisa.marenzoni@unipg.it.
Stefanetti, Valentina
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy, marialuisa.marenzoni@unipg.it.
Danzetta, Maria Luisa
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy, marialuisa.marenzoni@unipg.it.
Timoney, Peter Joseph
  • Department of Veterinary Science, Maxwell H Gluck Equine Research Center, Lexington, KY, USA.

Conflict of Interest Statement

Disclosure The authors report no conflicts of interest in the present work.

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