Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents.
Abstract: Progressive lung fibrosis in humans, typified by idiopathic pulmonary fibrosis (IPF), is a serious cause of morbidity and mortality in people. Similar diseases have been described in dogs, cats, and horses. The cause and pathogenesis of such diseases in all species is poorly understood. There is growing evidence in human medicine that IPF is a manifestation of abnormal wound repair in response to epithelial injury. Because viruses can contribute to epithelial injury, there is increasing interest in a possible role of viruses, particularly gammaherpesviruses, in the pathogenesis of pulmonary fibrosis. This review provides background information on progressive fibrosing lung disease in human and veterinary medicine and summarizes the evidence for an association between gammaherpesvirus infection and pulmonary fibrosis, especially Epstein-Barr virus in human pulmonary fibrosis, and equine herpesvirus 5 in equine multinodular pulmonary fibrosis. Data derived from experimental lung infection in mice with the gammaherpesvirus murine herpesvirus are presented, emphasizing the host and viral factors that may contribute to lung fibrosis. The experimental data are considered in the context of the pathogenesis of naturally occurring pulmonary fibrosis in humans and horses.
Publication Date: 2014-02-27 PubMed ID: 24569614DOI: 10.1177/0300985814521838Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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This study analyzes the potential link between gammaherpesviruses and the development of progressive lung fibrosis in humans and animals. The research reviews existing evidence regarding this connection, particularly focusing on Epstein-Barr virus in humans and equine herpesvirus 5 in horses, and also presents data from experimental lung infections in mice.
Understanding Progressive Lung Fibrosis and Gammaherpesviruses
- Progressive lung fibrosis, with idiopathic pulmonary fibrosis (IPF) as a typical example, is a severe condition that can cause significant illness and death in humans. Similar diseases are also prevalent in animals like dogs, cats, and horses.
- The exact causes and progression of these diseases across different species are not well understood.
- IPF in humans is increasingly being viewed as abnormal wound repair following epithelial injury. Epithelial injuries can be caused by viruses, which has led to a growing interest in understanding their potential role in the development of pulmonary fibrosis.
- Among viruses, gammaherpesviruses have particularly come under scrutiny for their potential role in the pathogenesis of pulmonary fibrosis.
Gammaherpesviruses and Pulmonary Fibrosis: Evidence from Human and Veterinary Medicine
- Substantial emphasis is put on gammaherpesviruses due to their potential association with the development of pulmonary fibrosis.
- In humans, the Epstein-Barr virus has been linked to the occurrence of pulmonary fibrosis. In horses, equine herpesvirus 5 has been connected to the development of equine multinodular pulmonary fibrosis.
- To understand the relationship further, the researchers evaluate data from experiments where mice were infected with the gammaherpesvirus murine herpesvirus to observe effects on the lungs.
The Impact of Host and Viral Factors on Lung Fibrosis
- The study findings underline the potential interaction between host factors and viral elements that can contribute to lung fibrosis.
- The experimental data is critically evaluated and contextualized in relation to the development and pathogenesis of naturally occurring pulmonary fibrosis in humans and horses.
- The research thus plays a crucial role in building a foundation for further investigation into the potential link between gammaherpesviruses and the development of lung fibrosis in humans and animals.
Cite This Article
APA
Williams KJ.
(2014).
Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents.
Vet Pathol, 51(2), 372-384.
https://doi.org/10.1177/0300985814521838 Publication
Researcher Affiliations
- Department of Pathobiology and Diagnostic Investigation, G380 Veterinary Medical Center, College of Veterinary Medicine, 784 Wilson Rd, Michigan State University, East Lansing, MI 48824, USA. Email: williamsk@dcpah.msu.edu.
MeSH Terms
- Animals
- Animals, Domestic
- Disease Models, Animal
- Gammaherpesvirinae / physiology
- Herpesviridae Infections / pathology
- Herpesviridae Infections / virology
- Horse Diseases / pathology
- Horse Diseases / virology
- Horses
- Humans
- Lung / pathology
- Lung / virology
- Mice
- Pulmonary Fibrosis / pathology
- Pulmonary Fibrosis / virology
Citations
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- Zhao W, Cheng J, Luo Y, Fu W, Zhou L, Wang X, Wang Y, Yang Z, Yao X, Ren M, Zhong Z, Wu X, Ren Z, Li Y. MicroRNA let-7f-5p regulates PI3K/AKT/COX2 signaling pathway in bacteria-induced pulmonary fibrosis via targeting of PIK3CA in forest musk deer.. PeerJ 2022;10:e14097.
- Maboni G, Kelly EJ, Clancy CS, De Luca E, Baldwin TJ, Van Wettere AJ, Kane AJ, Peterson S, Warr VG, Bastian DA, Sanchez S. Detection of asinine gammaherpesviruses in association with pulmonary fibrosis in free-ranging donkeys.. J Vet Diagn Invest 2022 Jan;34(1):167-171.
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