Genetic characterization of equine adenovirus type 1.
Abstract: Two known serotypes of equine adenovirus (EAdV), equine adenovirus type 1 (EAdV-1) and equine adenovirus type 2 (EAdV-2) have been isolated from horses. EAdV-1 is predominantly associated with upper respiratory tract infections while EAdV-2 appears to be associated with gastrointestinal infections in horses. In this report the EAdV-1 genome has been sequenced for the first time. The EAdV-1 genome encoded genes are characteristic of the Mastadenovirus genus such as protein V and IX. Unexpectedly, phylogenetic reconstructions also revealed a close relationship between EAdV-1 and two recently characterized bat adenoviruses. The results of this study suggest that EAdV-1 may share a common ancestor with canine and bat adenoviruses.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication Date: 2011-08-22 PubMed ID: 21924564DOI: 10.1016/j.vetmic.2011.08.014Google Scholar: Lookup
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Summary
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The research investigates the genetic structure of the equine adenovirus type 1 (EAdV-1), which is commonly associated with upper respiratory tract infections in horses. The study indicates that EAdV-1 may share a common ancestor with canine and bat adenoviruses.
Sequencing the EAdV-1 Genome
- The research centers around the genetic characterization of EAdV-1, which has been sequenced for the first time in this study. This procedure involves decoding the entire DNA sequence to understand its genetic structure and functions.
- The authors explain that EAdV-1 and EAdV-2 are the two known serotypes of horse adenovirus. Both serotypes have been isolated from horses, but they are associated with different infections. Specifically, EAdV-1 is usually seen in upper respiratory tract infections, whereas EAdV-2 appears to be linked to gastrointestinal infections in horses.
Genetic Characterization of EAdV-1
- Researchers found that the EAdV-1 genome has genes that are characteristic of the Mastadenovirus genus, such as protein V and IX. Mastadenovirus is a genus of viruses in the family Adenoviridae that includes human, bovine and canine adenoviruses among other species. The presence of characteristic Mastadenovirus genes in EAdV-1 might indicate genetic similarities and relations with adenoviruses observed in other species.
Phylogenetic Relationships
- The study further performed phylogenetic reconstructions, which are created to trace the evolutionary ancestry and histories of species. Again, this has been done for the very first time in this study for EAdV-1.
- The results of these reconstructions pointed towards a close relationship between EAdV-1 and two recently characterized bat adenoviruses. This implies that all these viruses might share a common ancestry or lineage.
- The revelation of a possible common ancestor between EAdV-1, canine and bat adenoviruses, as suggested in the study, deepens the understanding of adenovirus genetics and evolution across different species.
The outcomes of the study offer an entirely new perspective to the genetic constitution of equine adenoviruses and their evolutionary relationships, opening up avenues for more targeted and effective treatments of adenovirus infections.
Cite This Article
APA
Cavanagh HM, Mahony TJ, Vanniasinkam T.
(2011).
Genetic characterization of equine adenovirus type 1.
Vet Microbiol, 155(1), 33-37.
https://doi.org/10.1016/j.vetmic.2011.08.014 Publication
Researcher Affiliations
- School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
MeSH Terms
- Adenoviridae / classification
- Adenoviridae / genetics
- Adenoviridae Infections / veterinary
- Adenoviridae Infections / virology
- Animals
- Base Sequence
- Genome, Viral / genetics
- Horse Diseases / virology
- Horses
- Mastadenovirus / classification
- Mastadenovirus / genetics
- Phylogeny
Citations
This article has been cited 6 times.- Karamendin K, Kydyrmanov A, Sabyrzhan T, Nuralibekov S, Kasymbekov Y, Khan Y. Detection and Phylogenetic Characterization of a Novel Adenovirus Found in Lesser Mouse-Eared Bat (Myotis blythii) in South Kazakhstan. Viruses 2023 May 10;15(5).
- Athukorala A, Helbig KJ, Mcsharry BP, Forwood JK, Sarker S. Adenoviruses in Avian Hosts: Recent Discoveries Shed New Light on Adenovirus Diversity and Evolution. Viruses 2022 Aug 13;14(8).
- Lee SK, Choi J, Yoon J, Jung J, Park JY, Park J, Kim Y, Park JY, Park D. Molecular Detection of Equine Adenovirus 1 in Nasal Swabs from Horses in the Republic of Korea. Vet Sci 2022 Apr 13;9(4).
- Hackenbrack N, Rogers MB, Ashley RE, Keel MK, Kubiski SV, Bryan JA, Ghedin E, Holmes EC, Hafenstein SL, Allison AB. Evolution and Cryo-electron Microscopy Capsid Structure of a North American Bat Adenovirus and Its Relationship to Other Mastadenoviruses. J Virol 2017 Jan 15;91(2).
- Lima FE, Cibulski SP, Elesbao F, Carnieli Junior P, Batista HB, Roehe PM, Franco AC. First detection of adenovirus in the vampire bat (Desmodus rotundus) in Brazil. Virus Genes 2013 Oct;47(2):378-81.
- Enkhbat M, Batzorig U, Dashdondog N, Trujillo-Vargas CM, Dambadarjaa D, Gray GC. The Highly Interrelated Morbidity Respiratory Viruses Cause Among Humans and Animals in Mongolia. Viruses 2025 Nov 28;17(12).
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