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Genetic parameters for the prevalence of osteochondrosis in the limb joints of South German Coldblood horses.

Abstract: Heritabilities were estimated for osteochondrosis (OC) in fetlock and hock joints and palmar/plantar osseous fragments in fetlock joints of South German Coldblood (SGC) horses using Residual Maximum Likelihood (REML) under a linear animal model. The analyses were based on the results of a standardized radiographic examination of 167 SGC horses with a mean age of 14 months. The heritabilities linearly estimated and transformed onto the liability scale were for OC in fetlock joints 0.16 and for OC in hock joints 0.04. Considering fetlock and hock OC together, results in a heritability of 0.17. Palmar/plantar osseus fragments of the fetlock joints showed a heritability of 0.48. We concluded that there is most likely a genetic component in the variation of the development of osteochondrosis in fetlock and hock joints as well as for palmar/plantar osseus fragments of fetlock joints of the investigated population of SGC horses.
Publication Date: 2007-09-18 PubMed ID: 17868083DOI: 10.1111/j.1439-0388.2007.00670.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research investigates the heritability of osteochondrosis, a joint condition, in South German Coldblood horses. It finds a genetic component in the variation of the development of the condition in different joints.

Overview of the Research

  • The study focuses on analyzing the genetic parameters that influence the prevalence of a joint condition, osteochondrosis (OC), in South German Coldblood (SGC) horses.
  • Osteochondrosis is a developmental disorder in horses that affects the cartilage, leading to pain and impaired movement.
  • The prevalence of OC was examined in two main areas of the horse’s limbs, including the fetlock and hock joints, along with an analysis of palmar/plantar osseous fragments in fetlock joints. These terms refer to specific parts of a horse’s anatomy.

Methodology

  • Data for the study was collected by conducting a standardized radiographic examination (X-ray imaging) of 167 South German Coldblood horses, which had an average age of 14 months.
  • The researchers used a statistical analysis approach called Residual Maximum Likelihood (REML), under a linear animal model, to estimate the heritabilities of OC in the aforementioned joints.

Findings and Conclusion

  • The heritability of OC in fetlock joints was calculated to be 0.16, while in hock joints, it was 0.04. When both these joints were considered together, the heritability increased to 0.17.
  • The research showed that palmar/plantar osseus fragments of the fetlock joints had a remarkably high heritability of 0.48.
  • The results suggest that there likely exists a genetic component that accounts for the variation in the development of osteochondrosis in both fetlock and hock joints, as well as for palmar/plantar osseus fragments of the fetlock joints in the South German Coldblood horse population studied.

Cite This Article

APA
Wittwer C, Hamann H, Rosenberger E, Distl O. (2007). Genetic parameters for the prevalence of osteochondrosis in the limb joints of South German Coldblood horses. J Anim Breed Genet, 124(5), 302-307. https://doi.org/10.1111/j.1439-0388.2007.00670.x

Publication

ISSN: 0931-2668
NlmUniqueID: 100955807
Country: Germany
Language: English
Volume: 124
Issue: 5
Pages: 302-307

Researcher Affiliations

Wittwer, C
  • Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.
Hamann, H
    Rosenberger, E
      Distl, O

        MeSH Terms

        • Animals
        • Female
        • Forelimb
        • Genetic Markers
        • Hindlimb
        • Horse Diseases / diagnostic imaging
        • Horse Diseases / genetics
        • Horses
        • Joints
        • Likelihood Functions
        • Male
        • Osteochondritis / diagnostic imaging
        • Osteochondritis / genetics
        • Osteochondritis / veterinary
        • Radiography
        • Tarsal Bones / diagnostic imaging
        • Tarsus, Animal / diagnostic imaging

        Citations

        This article has been cited 5 times.
        1. Zimmermann E, Distl O. SNP-Based Heritability of Osteochondrosis Dissecans in Hanoverian Warmblood Horses. Animals (Basel) 2023 Apr 25;13(9).
          doi: 10.3390/ani13091462pubmed: 37174498google scholar: lookup
        2. Russell J, Matika O, Russell T, Reardon RJ. Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses. Equine Vet J 2017 May;49(3):282-287.
          doi: 10.1111/evj.12613pubmed: 27448988google scholar: lookup
        3. McCoy AM, Beeson SK, Splan RK, Lykkjen S, Ralston SL, Mickelson JR, McCue ME. Identification and validation of risk loci for osteochondrosis in standardbreds. BMC Genomics 2016 Jan 12;17:41.
          doi: 10.1186/s12864-016-2385-zpubmed: 26753841google scholar: lookup
        4. Bates JT, Jacobs JC Jr, Shea KG, Oxford JT. Emerging genetic basis of osteochondritis dissecans. Clin Sports Med 2014 Apr;33(2):199-220.
          doi: 10.1016/j.csm.2013.11.004pubmed: 24698039google scholar: lookup
        5. Corbin LJ, Blott SC, Swinburne JE, Sibbons C, Fox-Clipsham LY, Helwegen M, Parkin TD, Newton JR, Bramlage LR, McIlwraith CW, Bishop SC, Woolliams JA, Vaudin M. A genome-wide association study of osteochondritis dissecans in the Thoroughbred. Mamm Genome 2012 Apr;23(3-4):294-303.
          doi: 10.1007/s00335-011-9363-1pubmed: 22052004google scholar: lookup