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Emerging infectious diseases2010; 16(11); 1767-1769; doi: 10.3201/eid1611.100501

Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia.

Abstract: Bat-to-horse transmission of Hendra virus has occurred at least 14 times. Although clinical signs in horses have differed, genome sequencing has demonstrated little variation among the isolates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks.
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Publication Date: 2010-10-30 PubMed ID: 21029540PubMed Central: PMC3294518DOI: 10.3201/eid1611.100501Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the examination of Hendra virus transmission from bats to horses in Australia. Through genome sequencing of multiple isolates, it is found that there is little variation among the virus strains, and no correlation between sequences, time, and geographic location of the outbreaks.

Introduction to the Research

  • The article addresses the instance of at least 14 transmissions of the Hendra virus from bats to horses, a scenario that has previously occurred in Australia.
  • The research focuses on understanding the genome sequence conservation of these virus isolates during the spillover, or transmission, from one host species (bats) to another (horses).

Methodology

  • The researchers conducted genome sequencing of the Hendra virus from 5 isolates obtained during recent outbreaks in horses.
  • This sequencing allowed them to study the genetic material of the virus, to understand the magnitude of variation among different strains, and to explore any potential correlations with other variables such as time of outbreak and geographic location.

Key Findings

  • Despite observable differences in clinical signs among infected horses, the genome sequencing showed minimal variation among the Hendra virus isolates. This suggests a high degree of genetic stability in the virus during its spillover events.
  • Additionally, the researchers found no correlation between the genome sequences of these virus isolates and the time of outbreak or geographic locations. This finding contradicts the possibility that specific viral strains are associated with certain regions or periods, a pattern often observed in other pathogens.

Significance of the Research

  • The presence of a highly conserved Hendra virus genome in multiple spillover events indicates that the virus is capable of efficiently infecting and spreading among horses despite not adapting significantly at a genetic level.
  • Further understanding of this feature could potentially aid the development of more effective therapeutic interventions and preventative measures against the Hendra virus in horses.

Cite This Article

APA
Marsh GA, Todd S, Foord A, Hansson E, Davies K, Wright L, Morrissy C, Halpin K, Middleton D, Field HE, Daniels P, Wang LF. (2010). Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia. Emerg Infect Dis, 16(11), 1767-1769. https://doi.org/10.3201/eid1611.100501

Publication

Emerging infectious diseases
ISSN: 1080-6059
NlmUniqueID: 9508155
Country: United States
Language: English
Volume: 16
Issue: 11
Pages: 1767-1769

Researcher Affiliations

Marsh, Glenn A
  • Australian Animal Health Laboratory, Geelong, Victoria, Australia. glenn.marsh@csiro.au
Todd, Shawn
    Foord, Adam
      Hansson, Eric
        Davies, Kelly
          Wright, Lynda
            Morrissy, Chris
              Halpin, Kim
                Middleton, Deborah
                  Field, Hume E
                    Daniels, Peter
                      Wang, Lin-Fa

                        MeSH Terms

                        • Animals
                        • Australia / epidemiology
                        • Chiroptera
                        • Disease Outbreaks / veterinary
                        • Genome, Viral
                        • Hendra Virus / genetics
                        • Henipavirus Infections / epidemiology
                        • Henipavirus Infections / veterinary
                        • Henipavirus Infections / virology
                        • Horse Diseases / epidemiology
                        • Horse Diseases / virology
                        • Horses
                        • Phylogeny

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