Glucose uptake in horses with polysaccharide storage myopathy.
Abstract: To determine whether excessive glycogen accumulation in skeletal muscle of Quarter Horses with polysaccharide storage myopathy (PSSM) is a result of enhanced cellular uptake of glucose. Methods: 6 horses with PSSM and 10 healthy (control) horses. Methods: Intravenous glucose tolerance tests (IVGTT), oral glucose tolerance tests (OGTT), and modified insulin tolerance tests (MITT) were performed. Plasma glucose and insulin concentrations were measured in blood samples collected before and for up to 8 hours after glucose or insulin administration. Results: Peak glucose concentrations during IVGTT were similar for both groups of horses, but rate of glucose clearance was 1.5 times faster in horses with PSSM than in controls. Moreover, circulating concentrations of insulin before and after glucose injection were lower in the PSSM group. Blood glucose concentrations from minute 90 to minute 300 of the OGTT were lower in horses with PSSM than in controls. The MITT resulted in acute decreases in blood glucose concentrations in both groups of horses; however, horses with PSSM sustained low blood glucose concentrations for more than 3 hours after insulin injection, whereas blood glucose concentrations in controls returned to baseline values within 2 hours. Conclusions: Quarter Horses with PSSM have enhanced cellular uptake of glucose that may be, in part, caused by an increased sensitivity to insulin. Conclusions: Horses with PSSM have an increased rate of glucose clearance in response to insulin secretion. Thus, diets low in soluble carbohydrate may be the most effective way to decrease glycogen accumulation in skeletal muscle of these horses.
Publication Date: 1999-04-22 PubMed ID: 10211689
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research aims to evaluate if the excessive glycogen storage in the muscles of Quarter Horses with polysaccharide storage myopathy (PSSM) is due to better cellular glucose absorption. The results indicate that these horses show increased glucose uptake, potentially due to heightened insulin sensitivity. Therefore, diets low in soluble carbohydrates can be a practical way to reduce this excessive muscle glycogen accumulation.
Methodology
- This study comprised two groups; one group consisted of six horses diagnosed with polysaccharide storage myopathy (PSSM) while the other group was a control group with ten healthy horses.
- Three different tests were conducted on all horses: Intravenous glucose tolerance tests (IVGTT), oral glucose tolerance tests (OGTT), and modified insulin tolerance tests (MITT).
- These tests were followed by measuring plasma glucose and insulin concentrations in blood samples taken before and up to 8 hours post glucose or insulin administration.
Results
- The peak glucose levels during the IVGTT were similar for both groups.
- However, horses with PSSM showed a 1.5 times faster rate of glucose clearance compared to control horses. These horses also displayed lower circulating insulin concentrations before and after glucose injection.
- In the OGTT, horses with PSSM maintained lower blood glucose levels from minute 90 to minute 300 as compared to the healthy horses.
- The MITT triggered acute drops in blood glucose levels in both groups. However, the horses with PSSM kept low blood glucose levels for over 3 hours post insulin injection, while the control group’s glucose levels returned to baseline within 2 hours.
Conclusions
- The research concluded that Quarter Horses with PSSM show enhanced cellular glucose uptake, possibly due to increased insulin sensitivity.
- Consequently, horses with PSSM display a heightened rate of glucose clearing following insulin release.
- Studies suggest that diets containing low soluble carbohydrates might be effective in reducing glycogen accumulation in the skeletal muscle of these horses.
Cite This Article
APA
De La Corte FD, Valberg SJ, MacLeay JM, Williamson SE, Mickelson JR.
(1999).
Glucose uptake in horses with polysaccharide storage myopathy.
Am J Vet Res, 60(4), 458-462.
Publication
Researcher Affiliations
- Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
MeSH Terms
- Animals
- Blood Glucose / metabolism
- Female
- Glucose / pharmacokinetics
- Glucose Tolerance Test / veterinary
- Glycogen / metabolism
- Glycogen Storage Disease / metabolism
- Glycogen Storage Disease / pathology
- Glycogen Storage Disease / veterinary
- Horse Diseases / metabolism
- Horses
- Insulin / blood
- Male
- Muscle, Skeletal / metabolism
- Muscular Diseases / metabolism
- Muscular Diseases / pathology
- Muscular Diseases / veterinary
- Polysaccharides / metabolism
- Rhabdomyolysis / metabolism
- Rhabdomyolysis / pathology
- Rhabdomyolysis / veterinary
Citations
This article has been cited 3 times.- Corley KTT. Metabolic disorders in foals. Equine Vet Educ 2012 Aug;24(8):392-395.
- Barrey E, Mucher E, Jeansoule N, Larcher T, Guigand L, Herszberg B, Chaffaux S, Guérin G, Mata X, Benech P, Canale M, Alibert O, Maltere P, Gidrol X. Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. BMC Vet Res 2009 Aug 7;5:29.
- McCue ME, Valberg SJ, Miller MB, Wade C, DiMauro S, Akman HO, Mickelson JR. Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis. Genomics 2008 May;91(5):458-66.
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