Haematological changes in 2 ponies before and during an infection with equine influenza.
Abstract: MOST viral infections in animals, including man, have been
shown to alter the absolute and relative numbers of circulating
leucocytes. This usually causes a lymphopenia or neutropenia
but, occasionally, a lymphocytosis occurs (Gresser and Lang
1966). Several studies and reviews of respiratory viral
infections in horses have noted changes in the blood pictures
of infected animals, particularly during the early stages of the
disease (Steck and Gerber 1965; Gerber 1966, 1969; Bryans
and Gerber 1972; Hofer, Steck and Gerber 1978). The
transient nature of the leucocyte response is, probably,
responsible for the contradictory leucocyte changes reported in
influenza and other viral infections (Mumford and Rossdale
1980). Thus, demonstration of the leucocyte changes depends,
largely, upon the frequency with which blood samples are
collected throughout the course of the disease.
If the haematological response to viral infections is to be
used as an aid to diagnosis, then the changes occurring at
various stages of the disease have to be identified. This report
describes the haematological changes in 2 adult ponies before,
during and after infection by influenza A/equi/2 acquired
naturally, but coinciding with the administration of an
inactivated equine influenza vaccine.
Publication Date: 1982-04-01 PubMed ID: 6282583DOI: 10.1111/j.2042-3306.1982.tb02382.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates the changes in blood composition in two adult ponies during and after an infection with equine influenza. It also studies whether these changes can be used to identify the stages of the disease, which could potentially help in diagnosis and treatment.
Understanding the Context: Viral Infections and Blood Composition
- The research is based on the general understanding that viral infections tend to modify the count of circulating leucocytes (white blood cells), leading typically to lymphopenia (reduced level of certain white blood cells) or neutropenia (low count of neutrophils, a type of white blood cell), and sometimes to lymphocytosis (increase in certain type of white blood cells).
- With specific reference to respiratory viral infections in horses, changes in blood composition, especially in the early stages of the disease, have been observed in previous studies.
- These leucocyte changes can sometimes seem contradictory due to their transient nature. Their detection largely depends on how frequently blood samples are taken during the course of the disease.
The Aim of the Study: Hematological Response as a Diagnostic Tool
- The primary aim of this study is to understand whether the hematological responses (changes in blood composition) to viral infections can be used as a diagnostic tool.
- This requires the identification of the changes occurring at various stages of the disease.
The Study: Focusing on Equine Influenza
- The specific focus of this paper is equine influenza, a disease that affects horses.
- The research examines the hematological changes in two adult ponies before, during and after an infection by influenza type A/equi/2.
- The infection is acquired naturally, coinciding with the application of an inactivated equine influenza vaccine, adding an additional layer of complexity to measuring and understanding the hematological changes.
Implications and Potential Applications
- Understanding the hematological changes occurring throughout the course of equine influenza could provide valuable insight into not only disease progression but also the effectiveness of treatments like the equine influenza vaccine.
- If successful, the results could pave the way for blood composition changes to be used as a reliable, non-invasive method of disease stage diagnosis and progression tracking in equine diseases.
Cite This Article
APA
Allen BV, Frank CJ.
(1982).
Haematological changes in 2 ponies before and during an infection with equine influenza.
Equine Vet J, 14(2), 171-172.
https://doi.org/10.1111/j.2042-3306.1982.tb02382.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Eosinophils / cytology
- Female
- Horse Diseases / blood
- Horses / blood
- Influenza A virus
- Leukocyte Count
- Neutrophils / cytology
- Orthomyxoviridae Infections / blood
- Orthomyxoviridae Infections / veterinary
Citations
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