Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Haemodynamic effects of hyoscine-N-butylbromide in ponies.
Abstract: The haemodynamic effects of hyoscine-N-butylbromide (0.30 mg/kg, intravenously) were studied in eight adult ponies in a blinded two-period crossover experiment with repeated measures. Values for heart rate were 63%, 48% and 13% greater than control values at 1, 16 and 46 min, respectively, after administration of hyoscine-N-butylbromide. Cardiac output increased by 16% at 16 min after drug injection. Mean right atrial pressure was decreased by 79%, 63%, 45% and 52% at 1, 16, 46 and 61 min, respectively, after drug administration. Stroke volume was decreased by 32% at 1 min and pulmonary arterial wedge pressure was decreased by 44% at 16 min. We detected no significant difference in mean systemic arterial pressure, mean pulmonary arterial pressure, systemic vascular resistance or pulmonary vascular resistance at any time.
Publication Date: 1995-02-01 PubMed ID: 7752300DOI: 10.1111/j.1365-2885.1995.tb00544.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research study looks at how hyoscine-N-butylbromide, a drug, impacts the heart functions of adult ponies when administered intravenously.
Research Overview
- The research was conducted on eight adult ponies in a blinded two-period crossover experiment. This design ensured that each pony served as its own control and the results could be repeated to verify the findings.
- The drug used in this study, hyoscine-N-butylbromide or HBB, was administered intravenously at a dosage of 0.30 mg/kg.
- The researchers then monitored various parameters to measure the haemodynamic effects (how the drug influences the circulation of blood in the body) of HBB over time.
Findings
The drug HBB triggered changes in the horses’ cardiac functions, such as:
- Heart rate: The heart rate increased by 63%, 48%, and 13% in 1 minute, 16 minutes, and 46 minutes respectively, after the administration of the drug.
- Cardiac output: The amount of blood that the heart pumps in one minute increased by 16% just 16 minutes after the drug was injected.
- Mean right atrial pressure: The average pressure in the right atrium decreased significantly over time – by 79% at 1 minute, 63% at 16 minutes, 45% at 46 minutes, and 52% at 61 minutes after administration of the drug.
- Stroke volume and pulmonary arterial wedge pressure: The quantity of blood pumped by the heart per beat (stroke volume) was reduced by 32% at 1 minute after drug administration. At the same time, the pressure exerted by the blood within the pulmonary artery decreased by 44% after 16 minutes.
Significant Points
Despite the changes in other parameters, the researchers noted:
- There was no significant difference in the mean systemic arterial pressure, which is the blood pressure in the large arteries that deliver oxygenated blood to the body.
- The systemic vascular resistance (resistance faced in the peripheral blood vessels) and pulmonary vascular resistance (resistance in the lungs’ blood vessels) remained unaffected, showing no significant changes at all monitored points in time.
In conclusion, this study found that Hyoscine-N-butylbromide has broad-ranging impacts on the cardiovascular function of ponies when injected, causing notable alterations in heart rate, cardiac output, and various pressure measures, while leaving other parameters untouched.
Cite This Article
APA
Geimer TR, Ekström PM, Ludders JW, Erichsen DF, Gleed RD.
(1995).
Haemodynamic effects of hyoscine-N-butylbromide in ponies.
J Vet Pharmacol Ther, 18(1), 13-16.
https://doi.org/10.1111/j.1365-2885.1995.tb00544.x Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA.
MeSH Terms
- Animals
- Blood Pressure / drug effects
- Butylscopolammonium Bromide / administration & dosage
- Butylscopolammonium Bromide / pharmacology
- Butylscopolammonium Bromide / therapeutic use
- Cardiac Output / drug effects
- Cross-Over Studies
- Heart Rate / drug effects
- Hemodynamics / drug effects
- Horses / physiology
- Injections, Intravenous
- Pulmonary Wedge Pressure / drug effects
- Stroke Volume / drug effects
- Vascular Resistance / drug effects
Citations
This article has been cited 2 times.- Dufourni A, Demeyere M, Vernemmen I, Van Steenkiste G, Verhaeghe LM, van Loon G, Decloedt A. Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation. J Vet Intern Med 2025 Nov-Dec;39(6):e70254.
- Dufourni A, Buschmann E, Vernemmen I, Van Steenkiste G, van Loon G, Decloedt A. Effect of physiological and pharmacological stress on heart rate, blood pressure, and echocardiographic measurements in healthy Warmblood horses. J Vet Intern Med 2024 Jan-Feb;38(1):398-410.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
