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Home / Equine Research Bank / BMC Genomics / Hair follicle regional specificity in different parts of bay...
BMC genomics2020; 21(1); 651; doi: 10.1186/s12864-020-07064-1

Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling.

Abstract: Different morphological structures of hairs having properties like defense and camouflage help animals survive in the wild environment. Horse is one of the rare kinds of animals with complex hair phenotypes in one individual; however, knowledge of horse hair follicle is limited in literature and their molecular basis remains unclear. Therefore, the investigation of horse hair follicle morphogenesis and pigmentogenesis attracts considerable interest. Results: Histological studies revealed the morphology and pigment synthesis of hair follicles are different in between four different parts (mane, dorsal part, tail, and fetlock) of the bay Mongolian horse. Hair follicle size, density, and cycle are strongly associated with the activity of alkaline phosphatase (ALP). We observed a great difference in gene expression between the mane, tail, and fetlock, which had a greater different gene expression pattern compared with the dorsal part through transcriptomics. The development of the hair follicle in all four parts was related to angiogenesis, stem cells, Wnt, and IGF signaling pathways. Pigmentogenesis-related pathways were involved in their hair follicle pigment synthesis. Conclusions: Hair follicle morphology and the activity of ALP differ among four body parts in bay Mongolian horse. Hair follicles of the different body parts of the are not synchronized in their cycle stages. GO terms show a regional specificity pattern between different skin parts of the bay Mongolian horse. These results provide an insight into the understanding of the biological mechanism of the hair follicle in other mammals.
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Publication Date: 2020-09-22 PubMed ID: 32962644PubMed Central: PMC7510135DOI: 10.1186/s12864-020-07064-1Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the difference in hair follicle structures and related gene expressions in different parts of the Bay Mongolian horse’s body. The focus of the study includes the mane, dorsal part, tail, and fetlock, with a keen interest in their morphogenesis and pigmentogenesis.

Hair Follicle Morphology and Pigment Synthesis

  • The study found that the morphology and pigment synthesis of hair follicles differ significantly between the four areas studied in the Bay Mongolian horse.
  • Sizing, density, and even the cyclical nature of the hair follicle seem closely related to alkaline phosphatase (ALP) activity. ALP is an enzyme that is commonly associated with processes like growth and differentiation in several tissues.
  • Interestingly, the hair follicles in the different parts of the horse’s body are not synchronized in their cycle stages.

Examining Gene Expression

  • A significant focus of the research was the examination of differential gene expression in the mane, tail, and fetlock in comparison to the dorsal part.
  • This segment of the study involved transcriptomics, a method of studying the complete set of RNA transcripts produced by the genome, to discover differences in gene expression patterns between these areas.

Biological Pathways Involved

  • The study also found that the development of hair follicles in all four parts had close connections to certain biological pathways, including angiogenesis, stem cells, Wnt, and IGF signaling pathways.
  • Angiogenesis relates to the process where new blood vessels form from pre-existing vessels. The Wnt and IGF signaling pathways are essential communication routes between cells that coordinate numerous cellular functions like cell fate determination and stem cell maintenance.
  • The researchers noted that pigmentogenesis-related pathways were involved in hair follicle pigment synthesis.

Conclusions and Further Inspirations

  • The outcomes of this investigation showed that there is regional specificity in the morphology and activity of hair follicles between different skin parts of the bay Mongolian horses.
  • These findings provide insights that can be useful in understanding the biological mechanisms of hair follicles in other mammals, sparking potential for further research in this direction.

Cite This Article

APA
Zhao R, Yihan W, Zhao Y, Li B, Han H, Mongke T, Bao T, Wang W, Dugarjaviin M, Bai D. (2020). Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling. BMC Genomics, 21(1), 651. https://doi.org/10.1186/s12864-020-07064-1

Publication

BMC genomics
ISSN: 1471-2164
NlmUniqueID: 100965258
Country: England
Language: English
Volume: 21
Issue: 1
Pages: 651
PII: 651

Researcher Affiliations

Zhao, Ruoyang
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Yihan, Wu
  • Inner Mongolia Center for Disease Comprehensive Control and Prevention, Hohhot, 010030, China.
Zhao, Yiping
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Li, Bei
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Han, Haige
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Mongke, Togtokh
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Bao, Tugeqin
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Wang, Wenxing
  • Inner Mongolia Zhong Yun Horse Industry Group, Xilinhot, 026000, China.
Dugarjaviin, Manglai
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China.
Bai, Dongyi
  • lnner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction; Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs; Equine Research Center, College of animal science, Inner Mongolia Agricultural University, Zhao Wu Da Road, Hohhot, 306 010018, Inner Mongolia, China. baidongyi1983@163.com.

MeSH Terms

  • Alkaline Phosphatase / genetics
  • Alkaline Phosphatase / metabolism
  • Animals
  • Hair Follicle / cytology
  • Hair Follicle / metabolism
  • Horses / genetics
  • Organ Specificity
  • Skin Pigmentation
  • Transcriptome

Grant Funding

  • No.31960657, 31961143025 / National Natural Science Foundation of China
  • No.2017ZD06 / Natural Science Foundation Special Project of Inner Mongolia
  • No.ZD20190039 / Science and Technology major project of Inner Mongolia
  • No.2019MS03064 / National Natural Science Foundation of Inner Mongolia
  • No.QN202006, QN201909 / Youth Fund Project of Collage of Animal Science of Inner Mongolia Agricultural University
  • No.2017YFE0108700 / National Basic Research Program of China

Conflict of Interest Statement

The authors declare that they have no competing interests.

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