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Home / Equine Research Bank / Animals (Basel) / Hemodynamic Response to Lipopolysaccharide Infusion and Effe...
Animals : an open access journal from MDPI2024; 14(24); doi: 10.3390/ani14243660

Hemodynamic Response to Lipopolysaccharide Infusion and Effect of Meloxicam Administration on Cardiac Function in Donkeys.

Abstract: Systemic inflammatory response syndrome (SIRS) in donkeys is observed to be secondary to colic, diarrhea or pleuropneumonia, among other disorders. Horses with SIRS develop secondary disturbances such as hyperlipemia, laminitis, disseminated intravascular coagulopathy, and hemodynamic and cardiac derangements, which impair their prognosis and increase the mortality rate. In donkeys, no information is available on the effect of experimentally induced endotoxemia in the cardiovascular system. Acute experimental endotoxemia was induced by lipopolysaccharide (LPS) infusion in six healthy adult non-pregnant jennies. Physical signs, arterial (systolic, diastolic and mean) and central venous pressure were monitored during 360 min. Cardiac troponin I (cTnI) concentrations were measured in blood samples, and echocardiography was performed. LPS infusion caused an increase in cTnI, hypotension and diminution of central venous pressure, cardiac dysfunction, with a decrease in stroke volume (SV), cardiac output (CO) and cardiac index, and impairment of ultrasonographic ventricular function parameters. Intravenous meloxicam administration prevented the cTnI increase, hypotension, diminution of SV and CO, and changes in ultrasonographic parameters related to ventricular dysfunction. Thus, meloxicam could be proposed as an effective therapeutical option to control the hemodynamic and cardiac derangements observed in donkeys with SIRS.
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Publication Date: 2024-12-18 PubMed ID: 39765564PubMed Central: PMC11672460DOI: 10.3390/ani14243660Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study explores how a systemic inflammatory response syndrome (SIRS) in donkeys – commonly due to colic, diarrhea, or pleuropneumonia – can lead to heart problems and increase death rates. The research involved inducing experimental endotoxemia through a lipopolysaccharide (LPS) infusion in donkeys and studying the effect of meloxicam administration on their cardiac function.

Research Context

  • Often, donkeys experience systemic inflammatory response syndrome (SIRS), usually due to colic, diarrhea, or pleuropneumonia disorders. It’s observed that horses with SIRS show secondary disorders like hyperlipemia, laminitis, intravascular coagulopathy, and most importantly, cardiac and hemodynamic issues, increasing their mortality rate.
  • There was previously no data on the effect of induced endotoxemia on the cardiovascular system of donkeys. This study aims to bridge this gap by inducing acute experimental endotoxemia in donkeys using Lipopolysaccharide (LPS) infusion and studying the effect.

Methodology

  • The experiment involved six healthy adult non-pregnant donkeys. Researchers monitored their physical signs, arterial pressure (systolic, diastolic, and mean), and central venous pressure over six hours.
  • They also assessed cardiac troponin I (cTnI) concentrations in blood samples and carried out echocardiography tests.
  • The LPS infusion was observed to increase cTnI levels, drop blood pressure and central venous pressure, cause cardiac dysfunction, decrease stroke volume (SV), cardiac output (CO), cardiac index, and damage ultrasonographic ventricular function parameters.

Use of Meloxicam

  • The researchers then administered meloxicam intravenously to the donkeys.
  • The results showed that meloxicam prevented the cTnI increase, the fall in blood pressure, the reduction of SV and CO, and changes in ultrasonographic parameters related to ventricular dysfunction.

Conclusion

  • From the research, it can be concluded that meloxicam can effectively control the hemodynamic and cardiac problems in donkeys with SIRS. Therefore, it could be a potential therapeutic solution for these issues.

Cite This Article

APA
Mendoza FJ, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara CA, De Las Heras A, Perez-Ecija A. (2024). Hemodynamic Response to Lipopolysaccharide Infusion and Effect of Meloxicam Administration on Cardiac Function in Donkeys. Animals (Basel), 14(24). https://doi.org/10.3390/ani14243660

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 24

Researcher Affiliations

Mendoza, Francisco J
  • Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain.
Buzon-Cuevas, Antonio
  • Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain.
Aguilera-Aguilera, Raul
  • Egabro Veterinary Center, Cabra, 14940 Cordoba, Spain.
Gonzalez-De Cara, Carlos A
  • Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain.
De Las Heras, Adelaida
  • Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain.
Perez-Ecija, Alejandro
  • Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain.

Grant Funding

  • AGR-277 / Junta de Andalucía
  • Plan propio de investigacion / University of Córdoba

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 71 references
  1. Mendoza FJ, Toribio RE, Perez-Ecija A. Metabolic and endocrine insights in donkeys. Animals 2024;14:590.
    doi: 10.3390/ani14040590pmc: PMC10885905pubmed: 38396558google scholar: lookup
  2. Camillo F, Rota A, Biagini L, Tesi M, Fanelli D, Panzani D. The current situation and trend of donkey industry in Europe. J. Equine. Vet. Sci. 2018;65:44–49.
    doi: 10.1016/j.jevs.2017.11.008google scholar: lookup
  3. Costa LRR, Aleman M, Davis E. Comprehensive report of the caseload of donkeys and mules presented to a veterinary medical teaching hospital over a ten-year period. Animals 2019;9:413.
    doi: 10.3390/ani9070413pmc: PMC6680720pubmed: 31277260google scholar: lookup
  4. Mendoza FJ, Perez-Ecija RA, Monreal L, Estepa JC. Coagulation profiles of healthy Andalusian donkeys are different than those of healthy horses. J. Vet. Intern. Med. 2011;25:967–970.
    doi: 10.1111/j.1939-1676.2011.0748.xpubmed: 21736621google scholar: lookup
  5. Perez-Ecija A, Mendoza FJ. Characterisation of clotting factors, anticoagulant protein activities and viscoelastic analysis in healthy donkeys. Equine Vet. J. 2017;49:734–738.
    doi: 10.1111/evj.12685pubmed: 28323357google scholar: lookup
  6. Mendoza FJ, Toribio RE, Perez-Ecija A. Metabolic and endocrine disorders in donkeys. Vet. Clin. N. Am. Equine Pract. 2019;35:399–417.
    doi: 10.1016/j.cveq.2019.07.001pubmed: 31587976google scholar: lookup
  7. Mendoza FJ, Perez-Ecija RA, Toribio RE, Estepa JC. Thyroid hormone concentrations differ between donkeys and horses. Equine Vet. J. 2013;45:214–218.
    doi: 10.1111/j.2042-3306.2012.00622.xpubmed: 22909401google scholar: lookup
  8. Mendoza FJ, Toribio RE, Perez-Ecija A. Aspects of clinical relevance in donkeys. 2018. pp. 1513–1524.
  9. Taylor S. A review of equine sepsis. Equine Vet. Educ. 2015;27:99–109.
    doi: 10.1111/eve.12290pmc: PMC7163761pubmed: 32313390google scholar: lookup
  10. Mendoza FJ, Toribio RE, Perez-Ecija A. Donkey internal medicine—Part I: Metabolic, endocrine, and alimentary tract disturbances. J. Equine Vet. Sci. 2018;65:66–74.
    doi: 10.1016/j.jevs.2018.02.001google scholar: lookup
  11. Mendoza FJ, Toribio RE, Perez-Ecija A. Donkey Internal Medicine—Part II: Cardiovascular, respiratory, neurologic, urinary, ophthalmic, dermatology, and musculoskeletal Disorders. J. Equine Vet. Sci. 2018;65:86–97.
    doi: 10.1016/j.jevs.2018.02.025google scholar: lookup
  12. Mendoza FJ, Perez-Ecija A, Toribio RE. Clinical pharmacology in donkeys and mules. Vet. Clin. N. Am. Equine Pract. 2019;35:589–606.
    doi: 10.1016/j.cveq.2019.08.011pubmed: 31587974google scholar: lookup
  13. Sykes BW, Furr MO. Equine endotoxaemia—A state-of-the-art review of therapy. Aust. Vet. J. 2005;83:45–50.
    doi: 10.1111/j.1751-0813.2005.tb12191.xpubmed: 15971817google scholar: lookup
  14. Kelmer G. Update on treatments for endotoxemia. Vet. Clin. N. Am. Equine Pract. 2009;25:259–270.
    doi: 10.1016/j.cveq.2009.04.012pubmed: 19580938google scholar: lookup
  15. Werners AH, Bryant CE. Pattern recognition receptors in equine endotoxaemia and sepsis. Equine Vet. J. 2012;44:490–498.
    doi: 10.1111/j.2042-3306.2012.00574.xpmc: PMC7199481pubmed: 22607193google scholar: lookup
  16. El-Ashker M, El-Sebaei M, Aamer H. The influence of experimentally-induced endotoxaemia on clinical variables and markers of systemic inflammation in donkeys (Equus asinus). Vet. Med. Czech. 2017;62:117–124.
    doi: 10.17221/133/2016-VETMEDgoogle scholar: lookup
  17. Samimi AS, Samimi K, Karimiafshar M, Tajik J. Comparative anti-inflammatory effects of insulin and flunixin on acute-phase responses and cardiovascular biomarkers during inflammatory phase in miniature donkeys. J. Equine Vet. Sci. 2019;81:102788.
    doi: 10.1016/j.jevs.2019.102788pubmed: 31668307google scholar: lookup
  18. Mendoza Garcia FJ, Gonzalez-De Cara C, Aguilera-Aguilera R, Buzon-Cuevas A, Perez-Ecija A. Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys. J. Vet. Intern. Med. 2020;34:1631–1641.
    doi: 10.1111/jvim.15783pmc: PMC7379049pubmed: 32463537google scholar: lookup
  19. Perez-Ecija A, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara C, Mendoza FJ. Blood storage conditions affect hematological analysis in samples from healthy donkeys and donkeys with experimentally-induced endotoxemia. Front. Vet. Sci. 2020;7:640.
    doi: 10.3389/fvets.2020.00640pmc: PMC7511718pubmed: 33134340google scholar: lookup
  20. Perez-Ecija A, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara C, Mendoza Garcia FJ. Reference intervals of acute phase proteins in healthy Andalusian donkeys and response to experimentally induced endotoxemia. J. Vet. Intern. Med. 2021;35:580–589.
    doi: 10.1111/jvim.16015pmc: PMC7848381pubmed: 33336874google scholar: lookup
  21. Nostell K, Bröjer J, Höglund K, Edner A, Häggström J. Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia. Vet. J. 2012;192:171–175.
    doi: 10.1016/j.tvjl.2011.05.013pubmed: 21680208google scholar: lookup
  22. Pantaleon LG, Furr MO, McKenzie HC II, Donaldson L. Cardiovascular and pulmonary effects of Hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses. J. Vet. Intern. Med. 2006;20:1422–1428.
    doi: 10.1111/j.1939-1676.2006.tb00761.xpubmed: 17186860google scholar: lookup
  23. Hector RC, Rezende ML, Nelson BB, Monnet E. Cardiopulmonary function and intestinal blood flow in anaesthetised, experimentally endotoxaemic horses given a constant rate infusion of dexmedetomidine. Equine Vet. J. 2021;54:820–828.
    doi: 10.1111/evj.13513pubmed: 34528277google scholar: lookup
  24. Lazar DR, Lazar FL, Homorodean C, Cainap C, Focsan M, Cainap S, Olinic DM. High-sensitivity troponin: A review on characteristics, assessment, and clinical implications. Dis. Markers. 2022;2022:9713326.
    doi: 10.1155/2022/9713326pmc: PMC8965602pubmed: 35371340google scholar: lookup
  25. Barton MH, Moore JN, Norton N. Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin. Am. J. Vet. Res. 1997;58:1300–1307.
    doi: 10.2460/ajvr.1997.58.11.1300pubmed: 9361896google scholar: lookup
  26. Barton MH, Parviainen A, Norton N. Polymyxin B protects horses against induced endotoxaemia in vivo. Equine Vet. J. 2004;36:397–401.
    doi: 10.2746/0425164044868350pubmed: 15253079google scholar: lookup
  27. Jacobs CC, Holcombe SJ, Cook VL, Gandy JC, Hauptman JG, Sordillo LM. Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses. Equine Vet. J. 2013;45:333–339.
    doi: 10.1111/j.2042-3306.2012.00634.xpubmed: 22943507google scholar: lookup
  28. Mercer MA, Davis JL, McKenzie HC, Messenger KM, Schaefer E, Council-Troche RM, Werre SR. Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia. J. Vet. Intern. Med. 2023;37:718–727.
    doi: 10.1111/jvim.16663pmc: PMC10061170pubmed: 36840424google scholar: lookup
  29. Urayama S, Tanaka A, Kusano K, Sato H, Muranaka M, Mita H, Nagashima T, Matsuda H. Oral Administration of meloxicam and flunixin meglumine have similar analgesic effects after lipopolysaccharide-induced inflammatory response in Thoroughbred horses. J. Equine Vet. Sci. 2023;121:104205.
    doi: 10.1016/j.jevs.2022.104205pubmed: 36586521google scholar: lookup
  30. Sinclair MD, Mealey KL, Matthews NS, Peck KE, Taylor TS, Bennett BS. Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys. Am. J. Vet. Res. 2006;67:1082–1085.
    doi: 10.2460/ajvr.67.6.1082pubmed: 16740106google scholar: lookup
  31. Sheats MK. A comparative review of equine SIRS, sepsis, and neutrophils. Front. Vet. Sci. 2019;6:69.
    doi: 10.3389/fvets.2019.00069pmc: PMC6424004pubmed: 30931316google scholar: lookup
  32. Grenacher PA, Schwarzwald CC. Assessment of left ventricular size and function in horses using anatomical M-mode echocardiography. J. Vet. Cardiol. 2010;12:111–121.
    doi: 10.1016/j.jvc.2010.01.002pubmed: 20615777google scholar: lookup
  33. Schefer KD, Bitschnau C, Weishaupt MA, Schwarzwald CC. Quantitative analysis of stress echocardiograms in healthy horses with 2-dimensional (2D) echocardiography, anatomical M-mode, tissue Doppler imaging, and 2D speckle tracking. J. Vet. Intern. Med. 2010;24:918–931.
    doi: 10.1111/j.1939-1676.2010.0542.xpubmed: 20561187google scholar: lookup
  34. Hassan EA, Torad FA. Two-dimensional and M-mode echocardiographic measurements in the healthy donkey (Equus asinus). J. Equine Vet. Sci. 2015;35:283–289.
    doi: 10.1016/j.jevs.2015.01.016google scholar: lookup
  35. Roberts SL, Dukes-McEwan J. Echocardiographic reference ranges for sedentary donkeys in the UK. Vet. Rec. 2016;179:332.
    doi: 10.1136/vr.103734pubmed: 27539939google scholar: lookup
  36. Trim CM, Moore JN, Hardee MM, Hardee GE, Slade EA. Effects of an infusion of dopamine on the cardiopulmonary effects of Escherichia coli endotoxin in anaesthetised horses. Res. Vet. Sci. 1991;50:54–63.
    doi: 10.1016/0034-5288(91)90053-Qpubmed: 2047592google scholar: lookup
  37. Friedrichs KR, Harr KE, Freeman KP, Szladovits B, Walton RM, Barnhart KF, Blanco-Chavez J. ASVCP reference interval guidelines: Determination of de novo reference intervals in veterinary species and other related topics. Vet. Clin. Pathol. 2012;41:441–453.
    doi: 10.1111/vcp.12006pubmed: 23240820google scholar: lookup
  38. Tharwat M, Al-Sobayil F. Influence of the cardiac glycoside digoxin on cardiac troponin I, acid-base and electrolyte balance, and haematobiochemical profiles in healthy donkeys (Equus asinus). BMC Vet. Res. 2014;10:6.
    doi: 10.1186/1746-6148-10-64pmc: PMC3984684pubmed: 24621180google scholar: lookup
  39. Samimi AS, Poostfroush S, Samimi K, Tajik J. Comparative anti-inflammatory effects of insulin and dexamethasone on cardiovascular biomarkers and antioxidants in miniature donkeys subjected to induced carbohydrate overload. Equine Vet. Educ. 2022;34:e445–e450.
    doi: 10.1111/eve.13524google scholar: lookup
  40. Bikdeli B, Muriel A, Rodríguez C, González S, Briceño W, Mehdipoor G, Piazza G, Ballaz A, Lippi G, Yusen RD. High-sensitivity vs conventional troponin cutoffs for risk stratification in patients with acute pulmonary embolism. JAMA Cardiol. 2024;9:64–70.
    doi: 10.1001/jamacardio.2023.4356pmc: PMC10666041pubmed: 37991780google scholar: lookup
  41. Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW. Analytical validation of cardiac troponin I assays in horses. J. Vet. Diagn. Investig. 2018;30:226–232.
    doi: 10.1177/1040638717747070pmc: PMC6505877pubmed: 29224512google scholar: lookup
  42. Hassan MH, El-Beshbishy HA, Aly H, Attia SM, Bahashwan SA, Ghobara MM. Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice. Cancer Chemother. Pharmacol. 2014;74:559–569.
    doi: 10.1007/s00280-014-2544-3pubmed: 25053391google scholar: lookup
  43. Nakhaee P, Mosleh N, Nazifi S, Abdi-Hachesoo B, Hosseinian SA, Tavakoli Mohadeseh M. Comparative effects of meloxicam and dexamethasone in chickens with experimental systemic inflammation: Clinical outcome and cardiovascular parameters. Comp. Clin. Path. 2021;30:681–691.
    doi: 10.1007/s00580-021-03261-wgoogle scholar: lookup
  44. De Gennaro L, Brunetti ND, Cuculo A, Pellegrino PL, Izzo P, Roma F, Di Biase M. Increased troponin levels in nonischemic cardiac conditions and noncardiac diseases. J. Interv. Cardiol. 2008;21:129–139.
    doi: 10.1111/j.1540-8183.2007.00336.xpubmed: 18248355google scholar: lookup
  45. Kraus MS, Jesty SA, Gelzer AR, Ducharme NG, Mohammed HO, Mitchell LM, Soderholm LV, Divers TJ. Measurement of plasma cardiac troponin I concentration by use of a point-of-care analyzer in clinically normal horses and horses with experimentally induced cardiac disease. Am. J. Vet. Res. 2010;71:55–59.
    doi: 10.2460/ajvr.71.1.55pubmed: 20043781google scholar: lookup
  46. Wagner AE, Dunlop CI, Wertz EM, Chapman PL, Baxter GM, Klopp LS. Hemodynamic responses of horses to anesthesia and surgery, before and after administration of a low dose of endotoxin. Vet. Surg. 1995;24:78–85.
    doi: 10.1111/j.1532-950X.1995.tb01300.xpubmed: 7701776google scholar: lookup
  47. Borde L, Amory H, Leroux AA, Alhaidar A, Bordet FI, Detilleux J, Sandersen CC. Echocardiographic assessment of left ventricular systolic function in colic horses. J. Equine Vet. Sci. 2011;31:481–487.
    doi: 10.1016/j.jevs.2011.01.011google scholar: lookup
  48. Burrows GE. Endotoxaemia in the horse. Equine Vet. J. 1981;13:89–94.
    doi: 10.1111/j.2042-3306.1981.tb04120.xpubmed: 6265207google scholar: lookup
  49. Bottoms GD, Templeton CB, Fessler JF, Johnson MA, Roesel OF, Ewert KM, Adams SB. Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. Am. J. Vet. Res. 1982;43:999–1002.
    pubmed: 7049018
  50. Menzies-Gow NJ, Bailey SR, Katz LM, Marr CM, Elliott J. Endotoxin-induced digital vasoconstriction in horses: Associated changes in plasma concentrations of vasoconstrictor mediators. Equine Vet. J. 2004;36:273–278.
    doi: 10.2746/0425164044877260pubmed: 15147137google scholar: lookup
  51. Cudmore LA, Muurlink T, Whittem T, Bailey SR. Effects of oral clenbuterol on the clinical and inflammatory response to endotoxaemia in the horse. Res. Vet. Sci. 2013;94:682–686.
    doi: 10.1016/j.rvsc.2013.01.003pubmed: 23462621google scholar: lookup
  52. Pratt S, Barnes TS, Cowling N, de Klerk K, Rainger J, Sole-Guitart A, Woldeyohannes S, Goodwin W. Bias associated with peripheral non-invasive compared to invasive arterial blood pressure monitoring in healthy anaesthetised and standing horses using the Bionet BM7Vet. Vet. Sci. 2022;9:52.
    doi: 10.3390/vetsci9020052pmc: PMC8878245pubmed: 35202305google scholar: lookup
  53. Giguere S, Knowles HA, Valverde A, Bucki E, Young L. Accuracy of indirect measurement of blood pressure in neonatal foals. J. Vet. Intern. Med. 2005;19:571–576.
    doi: 10.1111/j.1939-1676.2005.tb02729.xpubmed: 16095176google scholar: lookup
  54. Heliczer N, Lorello O, Casoni D, Navas de Solis C. Accuracy and precision of noninvasive blood pressure in normo-, hyper-, and hypotensive standing and anesthetized adult horses. J. Vet. Intern. Med. 2016;30:866–872.
    doi: 10.1111/jvim.13928pmc: PMC4913577pubmed: 27059803google scholar: lookup
  55. Amory H, Bertrand P, Delvaux V, Sandersen C. Doppler echocardiographic reference values in healthy donkeys. 2004.
  56. Roberts SL, Dukes-McEwan J. Assessment of cardiovascular disease in the donkey: Clinical, echocardiographic and pathological observations. Vet. Rec. 2016;179:384.
    doi: 10.1136/vr.103733pubmed: 27534982google scholar: lookup
  57. Youssef MA, Ibrahim HM, Farag ESM, El-Khodery SA. Effects of tilmicosin phosphate administration on echocardiographic parameters in healthy donkeys (Equus asinus): An experimental study. J. Equine Vet. Sci. 2016;38:24–29.
    doi: 10.1016/j.jevs.2016.01.004google scholar: lookup
  58. Farag AMM, Ibrahim HMM. Reference values and repeatability of B-Mode and M-Mode echocardiographic parameters in healthy donkey (Equus asinus)—The guide to assess healthy heart. J. Equine Vet. Sci. 2020;88:102929.
    doi: 10.1016/j.jevs.2020.102929pubmed: 32303309google scholar: lookup
  59. Cruz-Aleixo AS, de Oliveira KC, de Oliveira Ferreira LV, Cedeo Quevedo DA, Cruz RKS, Tsunemi MH, Chiacchio SB, Lourenço MLG. Electrocardiographic and echocardiographic parameters in Pega breed donkeys: A descriptive study. Animals 2023;13:861.
    doi: 10.3390/ani13050861pmc: PMC10000045pubmed: 36899718google scholar: lookup
  60. Marzok M, Kandeel M, Alkhodair K, Abdel-Raheem S, Ismail H, Farag A, Ibrahim H, El-Ashkar M, Shousha S, El-Khodery S. Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): An experimental study. Front. Vet. Sci. 2023;10:1189710.
    doi: 10.3389/fvets.2023.1189710pmc: PMC10480612pubmed: 37680391google scholar: lookup
  61. Patteson MW, Gibbs C, Wotton PR, Cripps PJ. Echocardiographic measurements of cardiac dimensions and indices of cardiac function in normal adult thoroughbred horses. Equine Vet. J. Suppl. 1995;27:18–27.
    doi: 10.1111/j.2042-3306.1995.tb04985.xpubmed: 8933065google scholar: lookup
  62. Young LE, Marlin DJ, Deaton C, Brown-Feltner H, Roberts CA, Wood JL. Heart size estimated by echocardiography correlates with maximal oxygen uptake. Equine Vet. J. Suppl. 2002;34:467–471.
    doi: 10.1111/j.2042-3306.2002.tb05467.xpubmed: 12405735google scholar: lookup
  63. Al-haidar A, Farnir F, Deleuze S, Sandersen CF, Leroux AA, Borde L, Cerri S, Amory H. Effect of breed, sex, age and body weight on echocardiographic measurements in the Equine species. Res. Vet. Sci. 2013;95:255–260.
    doi: 10.1016/j.rvsc.2013.02.014pubmed: 23540604google scholar: lookup
  64. Borde L, Amory H, Grulke S, Leroux AA, Houben RM, Detilleux J, Sandersen CC. Prognostic value of echocardiographic and Doppler parameters in horses admitted for colic complicated by systemic inflammatory response syndrome. J. Vet. Emerg. Crit. Care. 2014;24:302–310.
    doi: 10.1111/vec.12177pubmed: 24690095google scholar: lookup
  65. Nath LC, Anderson GA, Hinchcliff KW, Savage CJ. Clinicopathologic evidence of myocardial injury in horses with acute abdominal disease. J. Am. Vet. Med. Assoc. 2012;241:1202–1208.
    doi: 10.2460/javma.241.9.1202pubmed: 23078568google scholar: lookup
  66. McConachie E, Barton MH, Rapoport G, Giguere S. Doppler and volumetric echocardiographic methods for cardiac output measurement in standing adult horses. J. Vet. Intern. Med. 2013;27:324–330.
    doi: 10.1111/jvim.12034pubmed: 23323806google scholar: lookup
  67. Baskett A, Barton MH, Norton N, Anders B, Moore JN. Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. Am. J. Vet. Res. 1997;58:1291–1299.
    doi: 10.2460/ajvr.1997.58.11.1291pubmed: 9361895google scholar: lookup
  68. Urayama S, Tanaka A, Kusano K, Sato H, Nagashima T, Fukuda I, Fujisawa C, Matsuda H. Oral Administration of meloxicam suppresses low-dose endotoxin challenge–induced pain in Thoroughbred horses. J. Equine Vet. Sci. 2019;77:139–143.
    doi: 10.1016/j.jevs.2019.03.001pubmed: 31133308google scholar: lookup
  69. Regan FH, Hockenhull J, Pritchard JC, Waterman-Pearson AE, Whay HR. Identifying behavioural differences in working donkeys in response to analgesic administration. Equine Vet. J. 2016;48:33–38.
    doi: 10.1111/evj.12356pubmed: 25256702google scholar: lookup
  70. Kriz NG, Rose RJ. Repeatability of standard transthoracic echocardiographic measurements in horses. Aust. Vet. J. 2002;80:362–370.
    doi: 10.1111/j.1751-0813.2002.tb14790.xpubmed: 12153063google scholar: lookup
  71. Slack J, Durando MM, Belcher CN, Collins N, Palmer L, Ousey J, Birks EK, Marr CM. Intraoperator, intraobserver and interoperator variability of echocardiographic measurements in healthy foals. Equine Vet. J. 2012;44:69–75.
    doi: 10.1111/j.2042-3306.2011.00503.xpubmed: 22594030google scholar: lookup
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