Hereditary Multiple Exostoses-A Comprehensive Examination of a 4-Year-Old Dutch Warmblood Male With Maternal Links to HME in First and Second Generations.
Abstract: Hereditary multiple exostoses (HME) is a condition rarely diagnosed in horses, which has not been previously reported in Dutch Warmblood horses. Its presentation resembles that diagnosed in humans, and it is predominantly active during periods of skeletal maturation. This case study reports a link between a granddam with no obvious HME lesions and its first and second generations presenting with HME, albeit with different sires. The severity in affected horses (n = 5) varied from one foreleg to the other with extensive multiple lesions of 123 of 205 bones in a half sibling in the first generation. In the second generation, axial deviations were reported, including similar lesions to those found in the first generation. Rib and limb lesions were the most commonly reported in the first and second generations by age four. However, an extensive examination of the 4-year Dutch Warmblood first generation male revealed lesions from the first cervical vertebra to the first caudal vertebra, inclusive of rib and limb lesions. As all horses with this condition are untreatable, early detection and diagnosis would provide the owner/breeder with options to avoid financial loss and emotional stress.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication Date: 2018-02-21 PubMed ID: 30973153DOI: 10.1016/j.jevs.2018.02.009Google Scholar: Lookup
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- Journal Article
Summary
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The study focuses on the existence of the rare condition, Hereditary Multiple Exostoses (HME), in Dutch Warmblood horses. Researchers in this case study observed the condition from its late manifestation in the maternal line to its full development in the first and second generations.
Background and Objectives
- The research aims to provide a comprehensive understanding of Hereditary multiple exostoses (HME), a condition that has seldom been diagnosed in horses, particularly Dutch Warmblood ones.
- The scientists in this case study aim at unraveling the genetic interplay in the manifestation of HME by studying its presentation in a maternal lineage over two generations.
- An essential objective of the study is exploring the possibility of early detection to help horse owners and breeders avoid financial losses and emotional distress.
Methods
- The researchers studied an affected granddam without apparent HME lesions and its first and second-generation offspring bearing the condition.
- The variations in severity among the affected horses (n=5), from significant limb differences to vast multiple lesions, were analyzed.
- They also used half a sibling from the first generation, with lesions on 123 of his 205 bones, to understand the extent of the condition.
Findings
- The researchers observed axial deviations in the second generation, including lesions similar to those seen in the first generation.
- Rib and limb lesions were the most frequently reported by the fourth year in both generations.
- An extensive examination of a 4-year Dutch Warmblood male from the first generation revealed lesions from the first cervical vertebra to the first caudal vertebra, including limb and rib lesions.
Implications
- The findings of this study have implications for the treatment and management of this currently untreatable condition.
- They add a higher accuracy understanding to the genetic build-up and manifestations of HME in horses, particularly Dutch Warmblood horses.
- They provide insights on early detection and diagnosis, necessary for horse owners and breeders to mitigate unfavorable outcomes.
Cite This Article
APA
May-Davis S, Doveren A, Sweere R, Smak J, Vermeulen Z.
(2018).
Hereditary Multiple Exostoses-A Comprehensive Examination of a 4-Year-Old Dutch Warmblood Male With Maternal Links to HME in First and Second Generations.
J Equine Vet Sci, 64, 55-58.
https://doi.org/10.1016/j.jevs.2018.02.009 Publication
Researcher Affiliations
- The University of New England, Canine and Equine Research Group, Armidale, New South Wales, Australia. Electronic address: maydavis@bigpond.com.
- The University of New England, Canine and Equine Research Group, Armidale, New South Wales, Australia.
- The University of New England, Canine and Equine Research Group, Armidale, New South Wales, Australia.
- The University of New England, Canine and Equine Research Group, Armidale, New South Wales, Australia.
- The University of New England, Canine and Equine Research Group, Armidale, New South Wales, Australia.
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