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Home / Equine Research Bank / Vet J / Herpesviral abortion in domestic animals.
Veterinary journal (London, England : 1997)1997; 153(3); 253-268; doi: 10.1016/s1090-0233(97)80061-5

Herpesviral abortion in domestic animals.

Abstract: Abortion or neonatal disease may follow infection with several alpha, beta and gamma-herpesviruses. The alpha-herpesvirus, equid herpesvirus-1 (EHV-1), causes single or epizootic abortions or neonatal deaths in equids, and the closely related virus EHV-4 causes sporadic equine abortions. In cattle, the alpha-herpesviruses, bovine herpesvirus-1 (infectious bovine rhinotracheitis virus) and bovine herpesvirus-5 (bovine encephalitis virus), and a gamma-herpesvirus, bovine herpesvirus-4, have all been implicated as causes of abortion. In pigs, suid herpesvirus-1 (SHV-1: pseudorabies virus), an alpha-herpesvirus, and SHV-2 (porcine cytomegalovirus), a beta-herpesvirus, each cause abortion or neonatal piglet losses. Caprine herpesvirus-1, canine herpesvirus and feline herpesvirus-1, all alpha-herpesviruses, cause abortions or neonatal deaths in goats, dogs and cats, respectively. This review discusses the pathogenesis, pathology and laboratory diagnosis of these herpesviral abortions and neonatal diseases, with an emphasis on experimental studies of each disease. Alternative reviews covering other aspects of each infection, such as the genetic and antigenic structure of the viruses, host immune responses and approaches to vaccination and disease control are indicated at appropriate points in the text.
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Publication Date: 1997-05-01 PubMed ID: 9232116DOI: 10.1016/s1090-0233(97)80061-5Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the impact of various types of herpesviruses on the reproductive health of domestic animals, often leading to abortions or neonatal diseases. The authors elaborate on the pathogenesis, pathology and laboratory diagnosis, with a focus on experimental studies of each disease.

Research Background and Objective

  • The research focuses on understanding the impact of herpesvirus infections in various domestic animals. The herpesviral types that affect these animals are classified as alpha, beta, and gamma-herpesviruses.
  • The authors aim to answer questions about disease occurrence, spread, detection, and the specific impacts of these herpesviruses when it comes to neonatal loss and abortion rates in these affected animals.

Herpesviruses and Affected Species

  • The alpha-herpesvirus, equid herpesvirus-1 (EHV-1), tends to affect equines (horses), leading to single or widespread abortions or neonatal deaths. A closely related virus, EHV-4, triggers sporadic abortions in horses.
  • In cattle, alpha-herpesviruses, namely bovine herpesvirus-1 and herpesvirus-5, along with a gamma-herpesvirus, bovine herpesvirus-4, are known to cause abortions.
  • Pigs are susceptible to suid herpesvirus-1 (an alpha-herpesvirus) and SHV-2 (a beta-herpesvirus), both of which can cause abortion or neonatal piglet losses.
  • Other alpha-herpesviruses, such as caprine herpesvirus-1, canine herpesvirus, and feline herpesvirus-1 are reported to cause abortions or neonatal deaths in goats, dogs, and cats, respectively.

Disease Pathogenesis and Diagnosis

  • The paper reviews the disease’s pathogenesis – that is, how the virus causes disease in the host animal – the subsequent pathology, and the options for laboratory diagnosis.
  • It emphasizes how experimental studies have helped contribute to our understanding of the disease, its spread and its effects, particularly in the light of abortion rates and neonatal deaths amongst affected animals.

Additional Aspects

  • The authors also include indications of alternative reviews that cover other aspects of each infection, such as the genetic and antigenic structure of the viruses, host immune responses, and possible approaches to vaccination and disease control.
  • These additional details provide a holistic view of the impact and mitigation strategies for herpesviral diseases in domestic animals.

Cite This Article

APA
Smith KC. (1997). Herpesviral abortion in domestic animals. Vet J, 153(3), 253-268. https://doi.org/10.1016/s1090-0233(97)80061-5

Publication

Veterinary journal (London, England : 1997)
ISSN: 1090-0233
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 153
Issue: 3
Pages: 253-268

Researcher Affiliations

Smith, K C
  • Centre for Preventive Medicine, Animal Health Trust, Newmarket, Suffolk, UK.

MeSH Terms

  • Abortion, Veterinary / diagnosis
  • Abortion, Veterinary / virology
  • Animals
  • Animals, Domestic / virology
  • Animals, Newborn / virology
  • Cats
  • Cattle
  • Dogs
  • Female
  • Fetal Death / virology
  • Herpesviridae / pathogenicity
  • Herpesviridae Infections / diagnosis
  • Herpesviridae Infections / veterinary
  • Herpesviridae Infections / virology
  • Pregnancy

Citations

This article has been cited 15 times.
  1. Tsai MS, Newman C, Macdonald DW, Buesching CD. Adverse weather during in utero development is linked to higher rates of later-life herpesvirus reactivation in adult European badgers, Meles meles.. R Soc Open Sci 2022 May;9(5):211749.
    doi: 10.1098/rsos.211749pubmed: 35582658google scholar: lookup
  2. Tsai MS, Fogarty U, Byrne AW, O'Keeffe J, Newman C, Macdonald DW, Buesching CD. Effects of Mustelid gammaherpesvirus 1 (MusGHV-1) Reactivation in European Badger (Meles meles) Genital Tracts on Reproductive Fitness.. Pathogens 2020 Sep 20;9(9).
    doi: 10.3390/pathogens9090769pubmed: 32962280google scholar: lookup
  3. Oliveira IVPM, Freire DAC, Ferreira HIP, Moura GHF, da Rocha CS, Calabuig CIP, Kurissio JK, Junior JPA, Antunes JMAP. Research on viral agents associated with feline reproductive problems reveals a high association with feline panleukopenia virus.. Vet Anim Sci 2018 Dec;6:75-80.
    doi: 10.1016/j.vas.2018.06.004pubmed: 32734056google scholar: lookup
  4. Holz CL, Sledge DG, Kiupel M, Nelli RK, Goehring LS, Soboll Hussey G. Histopathologic Findings Following Experimental Equine Herpesvirus 1 Infection of Horses.. Front Vet Sci 2019;6:59.
    doi: 10.3389/fvets.2019.00059pubmed: 30886853google scholar: lookup
  5. Poelaert KCK, Van Cleemput J, Laval K, Favoreel HW, Soboll Hussey G, Maes RK, Nauwynck HJ. Abortigenic but Not Neurotropic Equine Herpes Virus 1 Modulates the Interferon Antiviral Defense.. Front Cell Infect Microbiol 2018;8:312.
    doi: 10.3389/fcimb.2018.00312pubmed: 30258819google scholar: lookup
  6. Tavis JE, Wang H, Tollefson AE, Ying B, Korom M, Cheng X, Cao F, Davis KL, Wold WS, Morrison LA. Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication.. Antimicrob Agents Chemother 2014 Dec;58(12):7451-61.
    doi: 10.1128/AAC.03875-14pubmed: 25267681google scholar: lookup
  7. Schulman M, Becker A, Ganswindt S, Guthrie A, Stout T, Ganswindt A. The effect of consignment to broodmare sales on physiological stress measured by faecal glucocorticoid metabolites in pregnant Thoroughbred mares.. BMC Vet Res 2014 Jan 17;10:25.
    doi: 10.1186/1746-6148-10-25pubmed: 24433380google scholar: lookup
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    pubmed: 17695599
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    doi: 10.1128/JCM.44.2.666-668.2006pubmed: 16455943google scholar: lookup
  12. Keuser V, Gogev S, Schynts F, Thiry E. Demonstration of generalized infection with caprine herpesvirus 1 diagnosed in an aborted caprine fetus by PCR.. Vet Res Commun 2002 Apr;26(3):221-6.
    doi: 10.1023/a:1015205705149pubmed: 12090293google scholar: lookup
  13. Pickard GE, Smeraski CA, Tomlinson CC, Banfield BW, Kaufman J, Wilcox CL, Enquist LW, Sollars PJ. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits.. J Neurosci 2002 Apr 1;22(7):2701-10.
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    pubmed: 11041495
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    doi: 10.1023/a:1006210619910pubmed: 10359157google scholar: lookup
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