Histamine inhalation challenge in normal horses and in horses with small airway disease.
Abstract: A histamine inhalation challenge (HIC) procedure was developed to assess hyperreactive states in horses. Following clinical evaluation, percutaneous lung biopsies were performed on nine light breed mares aged 6 to 15 years. Five horses, with normal small airways, were classified as group A and four subjects with small airway disease (SAD) lesions formed group B. Pulmonary mechanics parameters were monitored following an aerosol of 0.9% saline and every 5 min for up to 30 min after HIC with 0.5% w/v of histamine diphosphate, administered through a face mask for 2.5 min. Tidal volume (VT) and airflow (V) values were obtained with a pneumotachograph. Transpulmonary pressure (delta Ppl) was measured by the esophageal balloon catheter method. Dynamic compliance (Cdyn), total pulmonary resistance (RL), end expiratory work of breathing (EEW) and respiratory rate (f) were calculated by a pulmonary mechanics computer. Group A horses had increases in RL, and decreases in Cdyn whereas horses in group B were hyperreactive and showed greater changes in EEW, Cdyn, and delta Ppl but with a relatively lower variation of RL. One horse in clinical remission from SAD, but with a high biopsy score (group B), and one clinically normal horse belonging to group A showed marked hyperreactivity as shown by increases in EEW, maximum change in delta Ppl and RL and decreases in Cdyn. These results suggest that the HIC described can be used as a method to investigate airway hyperreactivity and SAD in horses.
Publication Date: 1991-07-01 PubMed ID: 1889039PubMed Central: PMC1263466
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Airway Disease
- Asthma
- Biopsy
- Clinical Examination
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Diagnosis
- Diagnostic Technique
- Disease Diagnosis
- Disease Treatment
- Equine Diseases
- Equine Health
- Histamine
- Horses
- Lung Health
- Pathophysiology
- Pulmonary Health
- Respiratory Disease
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is about the development of a histamine inhalation challenge (HIC) procedure to assess lung hyperactivity in horses, particularly those with small airway disease.
Research Methodology
- The study participants were nine light breed mares aged between 6 to 15 years.
- After clinical evaluation, percutaneous lung biopsies were carried out on all participants.
- The horses were divided into two groups. Group A with normal small airways included 5 horses, while group B was comprised of 4 horses that had small airway disease lesions.
- An aerosol containing 0.9% saline was administered, followed by HIC with 0.5% w/v of histamine diphosphate. This administration was done via a face mask for a duration of 2.5 minutes.
- Pulmonary mechanics parameters were monitored for up to 30 minutes, with measures being taken every 5 minutes.
Data Collection
- A pneumotachograph was used to obtain Tidal volume (VT) and airflow (V) values.
- Transpulmonary pressure (delta Ppl) was gauged through the use of an esophageal balloon catheter method.
- Dynamic compliance (Cdyn), total pulmonary resistance (RL), end expiratory work of breathing (EEW), and respiratory rate (f) were calculated using a pulmonary mechanics computer.
Findings
- Horses in group A showed increases in RL and decreases in Cdyn.
- Horses in group B, on the other hand, showed heightened reactivity (hyperreactivity), with greater changes seen in EEW, Cdyn, and delta Ppl. However, their RL variation was relatively lower.
- One horse in clinical remission from SAD, but which had a high biopsy score (group B), and one clinically normal horse from group A showed pronounced hyperreactive responses. This was characterized by increased EEW, maximum change in delta Ppl and RL, and decreased Cdyn.
Conclusion
- The findings suggest that the HIC as described in the study can serve as an effective method for investigating airway hyperreactivity and SAD in horses.
Cite This Article
APA
Doucet MY, Vrins AA, Ford-Hutchinson AW.
(1991).
Histamine inhalation challenge in normal horses and in horses with small airway disease.
Can J Vet Res, 55(3), 285-293.
Publication
Researcher Affiliations
- Départment de médecine, Faculté de Médecine vétérinaire, Université de Montréal, Québec.
MeSH Terms
- Aerosols
- Airway Resistance
- Animals
- Biopsy / veterinary
- Bronchial Provocation Tests / veterinary
- Female
- Forced Expiratory Flow Rates
- Histamine
- Horse Diseases / physiopathology
- Horses
- Lung / pathology
- Lung Compliance
- Lung Diseases, Obstructive / physiopathology
- Lung Diseases, Obstructive / veterinary
- Nebulizers and Vaporizers / veterinary
- Pressure
- Respiration
- Respiratory Function Tests / veterinary
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Citations
This article has been cited 3 times.- Frippiat T, Art T, Tosi I. Airway Hyperresponsiveness, but Not Bronchoalveolar Inflammatory Cytokines Profiles, Is Modified at the Subclinical Onset of Severe Equine Asthma.. Animals (Basel) 2023 Aug 1;13(15).
- Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ. Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.. J Vet Intern Med 2017 Jul;31(4):1193-1201.
- Khol-Parisini A, van den Hoven R, Leinker S, Hulan HW, Zentek J. Effects of feeding sunflower oil or seal blubber oil to horses with recurrent airway obstruction.. Can J Vet Res 2007 Jan;71(1):59-65.
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