Histological evidence of superficial inflammation is associated with lower recurrence of equine sarcoids following surgical removal: A follow-up study of 106 tumours in 64 horses.
Abstract: Although the equine sarcoid is the most common skin neoplasm in domesticated horses, histopathological characteristics have not previously been evaluated for association with recurrence. The aim of this retrospective cohort study was to investigate clinical and histopathological features of excised equine sarcoids and to evaluate their association with recurrence at the original surgical site and at new sites. Clinical records and excisional biopsies from 106 equine sarcoids from 64 horses referred to Leahurst Equine Hospital, University of Liverpool, between March 2010 and February 2015 were retrieved. Biopsies were re-evaluated histologically. Clinical data were obtained from hospital records, and owner-reported follow-up data were obtained by telephone questionnaire. Associations between clinical and histopathological features of sarcoids and their recurrence at the surgical site were determined using uni- and multivariable mixed effects logistic regression. Recurrence of sarcoids at the surgical site occurred in 30 horses (46.9%). Sarcoids developed at a distant site in 21 horses (32.8%). In the final mixed effects logistic regression model, only superficial inflammation was associated with reduced odds of recurrence at the surgical site (adjusted odds ratio, 0.32; 95% confidence intervals, 0.10-0.96; P = 0.04). This suggests that the inflammatory process may play a role in protecting horses against the recurrence of sarcoids.
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication Date: 2023-02-11 PubMed ID: 36775186DOI: 10.1016/j.tvjl.2023.105953Google Scholar: Lookup
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- Journal Article
Summary
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The study focuses on the recurrence of equine sarcoids, a common type of skin tumor in horses, after surgical removal. It particularly looks into how characteristics from histopathological examinations may predict this recurrence. The results imply that inflammation near the skin’s surface might be instrumental in reducing the odds of sarcoids returning post-surgery.
Objective and Methodology
- The research aimed to discover the correlation between the histopathological features of removed equine sarcoids and their likelihood to reappear, either at the initial surgical site or elsewhere.
- The study reviewed clinical documents and excisional biopsies from 106 equine sarcoids obtained from 64 horses that were treated at Leahurst Equine Hospital, University of Liverpool, between 2010 and 2015.
- Biopsies were reanalyzed from a histological perspective to gather precise data on the sarcoid qualities, while clinical data was derived from hospital records.
- Follow-up information regarding the horses’ statuses post-surgery was procured from their owners via telephone and used to understand the recurrence of sarcoids.
Findings and Analysis
- After surgery, sarcoids recurred at the initial site in 46.9% of the horses (30 out of 64), while they also developed in distant areas in 32.8% of the horses (21 out of 64).
- The research utilized uni- and multivariable mixed effects logistic regression to establish potential links between the clinical and histopathological features of the sarcoids and their recurrence.
- According to the final logistic regression model, superficial inflammation – that is, inflammation at or just below the skin’s surface – was the sole feature associated with lower odds of sarcoid reappearance at the surgical site.
Implications
- The paper suggests that the superficial inflammatory process might have a protective role against the recurrence of sarcoids in horses.
- With the adjusted odds ratio at 0.32, demonstrating a 68% decrease with the presence of inflammation, these findings could be substantial for therapeutic strategies and preventive measures in equine healthcare.
Cite This Article
APA
Curnow B, Rich AF, Ireland J, Correa DC, Dunn J, Jenkins D, Carslake H, Ressel L.
(2023).
Histological evidence of superficial inflammation is associated with lower recurrence of equine sarcoids following surgical removal: A follow-up study of 106 tumours in 64 horses.
Vet J, 292, 105953.
https://doi.org/10.1016/j.tvjl.2023.105953 Publication
Researcher Affiliations
- Department of Equine Clinical Science, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK. Electronic address: benc@liv.ac.uk.
- Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Equine Clinical Science, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Equine Clinical Science, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Equine Clinical Science, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Equine Clinical Science, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
- Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
Conflict of Interest Statement
Conflict of interest statement None of the authors have any financial or personal relationships that could inappropriately influence or bias the results of this paper.
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