Hypercalcaemia and soft tissue mineralisation associated with lymphosarcoma in two horses.
Abstract: Two horses with deposits of lymphosarcoma, one in the spleen, the other in the mediastinum, several lymph nodes and kidneys, lost weight rapidly and became depressed and weak. They were hypercalcaemic and post mortem examination revealed extensive calcification of the heart and major vessels. There was no evidence of bone marrow metastases in the one horse whose marrow was examined, and the thyroid and parathyroid glands of both horses were grossly normal.
Publication Date: 1990-02-03 PubMed ID: 2309415
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- Case Reports
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article discusses about hypercalcaemia and soft tissue mineralisation related to lymphosarcoma in two horses. The horses presented significant weight loss, weakness and showed extensive calcification of the heart and major vessels after post mortem examination.
Introduction and Objective
- The research paper focuses on the occurrence of hypercalcaemia and soft tissue mineralisation, conditions associated with lymphosarcoma in two horses.
- Lymphosarcoma, a type of cancer that affects the lymphatic system was found in different internal organs in two horses.
Methodology and Results
- One horse had lymphosarcoma deposits in the spleen while the other had the deposits in the mediastinum, several lymph nodes and kidneys.
- The two horses exhibited rapid weight loss, general weakness and debility due to this malignancy.
- Both the horses were found to have hypercalcaemia, a condition characterised by high levels of calcium in the blood.
- After the death of these horses, post-mortem examinations revealed extensive calcification of the heart and major blood vessels, indicating the condition of soft tissue mineralisation.
Additional Analysis
- Further, in this study, no evidence of bone marrow metastases, or spread of cancer to the bone marrow, was found in the horse whose marrow was examined.
- Examination of the thyroid and parathyroid glands of both horses were observed to appear normal, with no gross abnormalities, suggesting these conditions were not influenced by dysfunction of these glands.
Conclusion
- The research concludes by linking the conditions of hypercalcaemia and soft tissue mineralisation with lymphosarcoma in horses, adding to the understanding of this disease in equine medicine.
- This study is important as it informs about the potential systemic effects of lymphosarcoma in horses, which can present itself beyond just the lymphatic system impacting the overall health and survival of the horses.
Cite This Article
APA
Mair TS, Yeo SP, Lucke VM.
(1990).
Hypercalcaemia and soft tissue mineralisation associated with lymphosarcoma in two horses.
Vet Rec, 126(5), 99-101.
Publication
Researcher Affiliations
- Department of Veterinary Medicine, University of Bristol, School of Veterinary Science.
MeSH Terms
- Animals
- Calcinosis / etiology
- Calcinosis / veterinary
- Cardiovascular Diseases / etiology
- Cardiovascular Diseases / veterinary
- Female
- Horse Diseases / etiology
- Horses
- Hypercalcemia / etiology
- Hypercalcemia / veterinary
- Kidney Neoplasms / complications
- Kidney Neoplasms / veterinary
- Lymph Nodes / pathology
- Lymphoma, Non-Hodgkin / complications
- Lymphoma, Non-Hodgkin / veterinary
- Mediastinal Neoplasms / complications
- Mediastinal Neoplasms / veterinary
- Splenic Neoplasms / complications
- Splenic Neoplasms / veterinary
Grant Funding
- Wellcome Trust
Citations
This article has been cited 3 times.- Drozdzewska K, Gehlen H. Markers for internal neoplasia in the horse. Vet Med Sci 2023 Jan;9(1):132-143.
- Muñoz A, Riber C, Trigo P, Castejón F. Hematopoietic neoplasias in horses: myeloproliferative and lymphoproliferative disorders. J Equine Sci 2009;20(4):59-72.
- Tan JY, Valberg SJ, Sebastian MM, Davis GD, Kelly JR, Goehring LS, Harland MM, Kuebelbeck KL, Waldridge BM, Newton JC, Reimer JM. Suspected systemic calcinosis and calciphylaxis in 5 horses. Can Vet J 2010 Sep;51(9):993-9.
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