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Equine veterinary journal. Supplement2001; (32); 19-25; doi: 10.1111/j.2042-3306.2000.tb05329.x

Hypercoagulation and hypofibrinolysis in horses with colic and DIC.

Abstract: Changes in haemostasis in horses with colic were assessed by using specific and sensitive markers of coagulation and fibrinolysis activity. Blood samples from 41 horses with severe colic and from 30 healthy control horses were tested. Diagnosis of DIC was based on the findings of at least 3 of 6 abnormalities: thrombocytopenia, prolonged clotting times (PT and APTT), increased polyclonal FDPs, decreased fibrinogen and decreased AT-III activity. Plasma thrombin-antithrombin III complexes (TAT), monoclonal fibrin degradation products fragment D (D-dimer) and monoclonal fibrinogen degradation products (FgDP) were also tested by using ELISA kits. DIC was diagnosed in 16 of 41 horses with colic. Compared to control and non-DIC colic values, TAT was significantly (P < 0.000) greater in horses with colic and DIC (Control group, mean +/- s.d. 2.6 +/- 2; non-DIC colic group, 7.5 +/- 9, and DIC colic group, 30.9 +/- 36 ng/ml). Also, D-dimer was significantly (P < 0.000) less in the DIC group when compared to control and non-DIC colic values (mean +/- s.d. 677 +/- 119, 682 +/- 220 and 399 +/- 234 ng/ml, respectively). Compared to non-DIC colic values, FgDP was significantly (P < 0.05) lower in the DIC group (363 +/- 111, 437 +/- 230 and 293 +/- 187 ng/ml respectively). Both PT and APTT showed a significant positive correlation with TAT. DIC was more common among nonsurvivors and horses with ischaemic bowel. We conclude that a hypercoagulative state was detected in horses with colic, which was stronger in horses with colic and DIC. Hypofibrinolysis was present only in horses with DIC. Therefore, marked hypercoagulation together with hypofibrinolysis are associated with DIC in horses.
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Publication Date: 2001-02-24 PubMed ID: 11202377DOI: 10.1111/j.2042-3306.2000.tb05329.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study evaluates changes in the clotting and dissolving of clots in 41 horses with severe colic symptoms. It was found that there is a higher rate of clot formation (hypercoagulation) and a decreased rate of clot dissolution (hypofibrinolysis) in horses with colic and disseminated intravascular coagulation (DIC) compared to healthy or colic-only horses.

Research Methods

  • The researchers collected blood samples from 41 horses suffering from severe colic and 30 healthy control horses.
  • The diagnosis of DIC was based on at least 3 of 6 abnormities including thrombocytopenia, prolonged clotting times, high fibrin degradation products, low fibrinogen, and decreased antithrombin activity.
  • Blood test markers were used to determine the level of clotting (hypercoagulation) and lack of clot breakdown (hypofibrinolysis) in the horse’s systems.

Key Findings

  • DIC was diagnosed in 16 out of the 41 horses with severe colic.
  • Those horses with both colic and DIC had much higher levels of the clotting indicator thrombin-antithrombin III complexes (TAT) in comparison to the healthy or colic-only horses.
  • In horses with DIC, there was a significant decrease in D-dimer, an indicator of clot breakdown (fibrinolysis), as well as fibrinogen degradation products (FgDP), another fibrinolytic indicator, as compared to healthy and non-DIC colic horses.
  • Both prolonged clotting times (PT and APTT) showed significant positive correlation with levels of TAT, indicating that increased clotting is associated with prolonged clotting times.
  • DIC was more common among nonsurvivors and horses with ischemic bowel.

Conclusions

  • The study concludes that a state of hypercoagulation is detected in horses with colic and is strongest in the presence of DIC.
  • Hypofibrinolysis was only evident in horses with DIC.
  • Therefore, a high rate of clot formation coupled with a reduced rate of clot breakdown are associated with DIC in horses.

Cite This Article

APA
Monreal L, Anglés A, Espada Y, Monasterio J, Monreal M. (2001). Hypercoagulation and hypofibrinolysis in horses with colic and DIC. Equine Vet J Suppl(32), 19-25. https://doi.org/10.1111/j.2042-3306.2000.tb05329.x

Publication

Equine veterinary journal. Supplement
NlmUniqueID: 9614088
Country: United States
Language: English
Issue: 32
Pages: 19-25

Researcher Affiliations

Monreal, L
  • Unitat Experimental de Trombosi, Dept. Patologia Mèdica, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193-Barcelona, Spain.
Anglés, A
    Espada, Y
      Monasterio, J
        Monreal, M

          MeSH Terms

          • Animals
          • Antithrombin III / metabolism
          • Antithrombin III Deficiency / veterinary
          • Colic / diagnosis
          • Colic / veterinary
          • Disseminated Intravascular Coagulation / diagnosis
          • Disseminated Intravascular Coagulation / veterinary
          • Fibrin Fibrinogen Degradation Products / analysis
          • Fibrinolysis
          • Gastrointestinal Diseases / blood
          • Gastrointestinal Diseases / diagnosis
          • Gastrointestinal Diseases / mortality
          • Hemostasis
          • Horse Diseases / blood
          • Horse Diseases / diagnosis
          • Horse Diseases / mortality
          • Horses
          • Peptide Hydrolases / blood
          • Predictive Value of Tests
          • Sensitivity and Specificity
          • Spain / epidemiology
          • Thrombophilia / veterinary

          Citations

          This article has been cited 12 times.
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