Hyperlipoproteinaemia in ponies: mechanisms and response to therapy.
Abstract: (I) The lipid and lipoprotein concentrations in sera of 4 healthy and 9 hyperlipaemic patients were determined. From the results of the analyses, it is suggested that three types of hyperlipoproteinaemia can be distinguished in ponies: (a) Type 1, characterised by a very pronounced increase in only the very low density lipoproteins (VLDL); (b) Type 2, in which there is a pronounced increase in the chylomicrons (Chylo) and the very low density lipoproteins (VLDL); (c) Type 3, which can be the result of fasting and is characterised by a moderate increase in the concentration of chylomicrons and a greater increase in very low density lipoproteins. It is suggested that hyperlipoproteinaemia in ponies can be classified on the basis of electrophoretic patterns. (II) To gather more information on the metabolism of extra offered lipids, blood from ponies suffering from two different types of hyperlipoproteinaemia was transfused into normal ponies and the changes in lipid and lipoprotein concentrations in the blood serum were followed. The reactions were different. When heparin was used as anticoagulant a great increase in chylomicrons and a significant increase in very low density lipoproteins in a healthy pony was observed. When sodium citrate was used as anticoagulant a clear increase in the VLDL fraction only was noticed.
Publication Date: 1975-01-06 PubMed ID: 164302DOI: 10.1016/0009-8981(75)90479-9Google Scholar: Lookup
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- Journal Article
Summary
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The research involves studying lipid and lipoprotein concentrations in the blood serum of ponies, distinguishing three types of hyperlipoproteinaemia, and observing the metabolic response to transfusing blood from hyperlipaemic ponies to healthy ones.
Types of Hyperlipoproteinaemia in Ponies
- The paper initially presents the classification of hyperlipoproteinaemia in ponies into three types based on an analysis of lipid and lipoprotein concentrations in the serum of healthy and hyperlipaemic ponies.
- Type 1 is characterized by a significant increase in very low density lipoproteins (VLDL) only.
- Type 2 shows a pronounced increase in both chylomicrons (Chylo) and very low density lipoproteins.
- Type 3 could result from fasting and is marked by a modest rise in chylomicron concentration and a greater increase in very low density lipoproteins.
- The researchers suggest that hyperlipoproteinaemia in ponies can be classified based on electrophoretic patterns.
Metabolic Response to Lipid Transfusion
- Further, the paper studies the impact of extra offered lipids on the organism’s metabolism. The researchers transfuse blood from ponies with two different types of hyperlipoproteinaemia into healthy ponies and monitor changes in lipid and lipoprotein concentrations in the serum.
- The results are varied depending on the anticoagulant used. When heparin was used, a significant increase in chylomicrons and very low density lipoproteins was observed in the healthy pony’s serum.
- Conversely, when sodium citrate was used as the anticoagulant, a clear increase was noticed in the VLDL fraction only.
Implications of the Findings
- The findings from this research potentially provide scientists with a more nuanced understanding of hyperlipoproteinaemia in ponies, paving way for more effective therapeutic interventions.
- Understanding how different lipid types and anticoagulant solutions affect lipoprotein concentrations in blood transfusions may help in optimizing procedures.
Cite This Article
APA
Wensing T, van Gent DM, Schotman AJ, Kroneman J.
(1975).
Hyperlipoproteinaemia in ponies: mechanisms and response to therapy.
Clin Chim Acta, 58(1), 1-15.
https://doi.org/10.1016/0009-8981(75)90479-9 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Blood Transfusion
- Cholesterol / blood
- Diglycerides / blood
- Fatty Acids, Nonesterified / blood
- Horses / blood
- Hyperlipidemias / blood
- Hyperlipidemias / drug therapy
- Hyperlipidemias / genetics
- Hyperlipidemias / veterinary
- Lipoproteins / blood
- Lipoproteins, VLDL / blood
- Phospholipids / blood
- Triglycerides / blood
Citations
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