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Home / Equine Research Bank / J Virol / Identification of a pegivirus (GB virus-like virus) that inf...
Journal of virology2013; 87(12); 7185-7190; doi: 10.1128/JVI.00324-13

Identification of a pegivirus (GB virus-like virus) that infects horses.

Abstract: The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
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Publication Date: 2013-04-17 PubMed ID: 23596285PubMed Central: PMC3676142DOI: 10.1128/JVI.00324-13Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on the discovery of a new virus, named equine pegivirus (EPgV), that infects horses. It further explores its unique genomic features and persistent viremia caused by the virus, while leaving its clinical significance undetermined.

Nonprimate Hepaciviruses in Canines and Horses

  • Earlier research identified nonprimate hepaciviruses in dogs and horses, which led researchers to investigate the existence of pegiviruses (viruses similar to GB virus) in these species.
  • Pegiviruses were not found in canines, but were present in horses, indicating a new species-specific pattern of infection.

Discovery of a New Virus in Horses: Equine Pegivirus

  • The researchers found widespread, natural infection of horses by a novel pegivirus, which they tentatively named equine pegivirus (EPgV).
  • This virus is unique and does not resemble any previously identified virus, suggesting its classification as a new species within the Pegivirus genus.

Genomic Features and Phylogenetic Analysis of Equine Pegivirus

  • The study also looked into the unique genomic features of the EPgV. These features were used to confirm its status as a novel species within the Pegivirus genus.
  • Phylogenetic analysis — an evolutionary analysis used to deduce relationships among species or individuals — was used to further cement EPgV’s status as a unique virus.

Persistent Viremia Caused by Equine Pegivirus

  • The study found that EPgV causes persistent viremia — a condition where the virus continues to exist in the bloodstream for a long period.
  • However, the clinical significance of this persistent viremia caused by EPgV is yet to be determined. Meaning, it is not clear whether this persistent viremia induces any disease or syndrome in the infected horses.

Cite This Article

APA
Kapoor A, Simmonds P, Cullen JM, Scheel TK, Medina JL, Giannitti F, Nishiuchi E, Brock KV, Burbelo PD, Rice CM, Lipkin WI. (2013). Identification of a pegivirus (GB virus-like virus) that infects horses. J Virol, 87(12), 7185-7190. https://doi.org/10.1128/JVI.00324-13

Publication

Journal of virology
ISSN: 1098-5514
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 87
Issue: 12
Pages: 7185-7190

Researcher Affiliations

Kapoor, Amit
  • Center for Infection and Immunity, Columbia University, New York, New York, USA. ak3117@columbia.edu
Simmonds, Peter
    Cullen, John M
      Scheel, Troels K H
        Medina, Jan L
          Giannitti, Federico
            Nishiuchi, Eiko
              Brock, Kenny V
                Burbelo, Peter D
                  Rice, Charles M
                    Lipkin, W Ian

                      MeSH Terms

                      • Amino Acid Sequence
                      • Animals
                      • Base Sequence
                      • Flaviviridae / classification
                      • Flaviviridae / genetics
                      • Flaviviridae Infections / epidemiology
                      • Flaviviridae Infections / veterinary
                      • Flaviviridae Infections / virology
                      • Horse Diseases / epidemiology
                      • Horse Diseases / virology
                      • Horses / virology
                      • Molecular Sequence Data
                      • Phylogeny
                      • Prevalence
                      • Sequence Analysis, DNA
                      • Species Specificity
                      • United States / epidemiology
                      • Viremia / epidemiology
                      • Viremia / virology

                      Grant Funding

                      • R01 AI072613 / NIAID NIH HHS
                      • AI090055 / NIAID NIH HHS
                      • AI070411 / NIAID NIH HHS
                      • U01 AI070411 / NIAID NIH HHS
                      • 095831 / Wellcome Trust
                      • R01 AI090055 / NIAID NIH HHS
                      • U54 AI057158 / NIAID NIH HHS
                      • AI072613 / NIAID NIH HHS
                      • EY017404 / NEI NIH HHS
                      • R21 AI090196 / NIAID NIH HHS
                      • R01 AI079231 / NIAID NIH HHS
                      • AI57158 / NIAID NIH HHS
                      • CA057973 / NCI NIH HHS
                      • R24 EY017404 / NEI NIH HHS
                      • AI079231 / NIAID NIH HHS
                      • AI090196 / NIAID NIH HHS
                      • R01 CA057973 / NCI NIH HHS

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