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Home / Equine Research Bank / Genes Immun / IgE-binding monocytes upregulate the coagulation cascade in ...
Genes and immunity2023; 24(3); 130-138; doi: 10.1038/s41435-023-00207-w

IgE-binding monocytes upregulate the coagulation cascade in allergic horses.

Abstract: IgE-binding monocytes are a rare peripheral immune cell type involved in the allergic response through binding of IgE on their surface. IgE-binding monocytes are present in both healthy and allergic individuals. We performed RNA sequencing to ask how the function of IgE-binding monocytes differs in the context of allergy. Using a large animal model of allergy, equine Culicoides hypersensitivity, we compared the transcriptome of IgE-binding monocytes in allergic and non-allergic horses at two seasonal timepoints: (i) when allergic animals were clinical healthy, in the winter "Remission Phase", and (ii) during chronic disease, in the summer "Clinical Phase". Most transcriptional differences between allergic and non-allergic horses occurred only during the "Remission Phase", suggesting principal differences in monocyte function even in the absence of allergen exposure. F13A1, a subunit of fibrinoligase, was significantly upregulated at both timepoints in allergic horses. This suggested a role for increased fibrin deposition in the coagulation cascade to promote allergic inflammation. IgE-binding monocytes also downregulated CCR10 expression in allergic horses during the "Clinical Phase", suggesting a defect in maintenance of skin homeostasis, which further promotes allergic inflammation. Together, this transcriptional analysis provides valuable clues into the mechanisms used by IgE-binding monocytes in allergic individuals.
© 2023. The Author(s).
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Publication Date: 2023-05-16 PubMed ID: 37193769PubMed Central: PMC10266973DOI: 10.1038/s41435-023-00207-wGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examines the role of a unique immune cell type, IgE-binding monocytes, in allergic responses in horses. The research identifies significant differences in the function of these cells in allergic versus non-allergic horses, suggesting they may play a prominent role in allergic inflammation.

Research Methodology

  • The researchers performed RNA sequencing to investigate the function of IgE-binding monocytes in allergic environments compared to non-allergic ones. This high-throughput method allows for analyzing the expression of thousands of genes simultaneously, giving a comprehensive picture of cellular function.
  • The study used a large animal model of allergy, specifically equine Culicoides hypersensitivity, a common and severe allergic disease in horses.
  • The team compared the gene expression of IgE-binding monocytes in allergic and non-allergic horses at two seasonal times: during winter “Remission Phase” when allergic horses were clinically healthy and during summer “Clinical Phase”, a time of chronic disease.

Key Findings

  • Most differences in gene expression between allergic and non-allergic horses were observed in the “Remission Phase”, indicating key differences in monocyte function even without allergen exposure.
  • The gene F13A1, a subunit of the enzyme responsible for fibrin formation in blood clotting, was more active in allergic horses at both time points. This suggests that increased fibrin creation in the coagulation cascade could contribute to allergic inflammation.
  • The researchers also discovered that the CCR10 gene – a receptor that plays a role in skin health and immune responses – was less active in allergic horses during the “Clinical Phase”. This indicates potential issues with maintaining skin health, which could further exacerbate allergic inflammation.

Research Implications

  • The findings from the transcriptional analysis provide new insights into the mechanisms by which IgE-binding monocytes contribute to allergic responses. Understanding these mechanisms could inform the development of new treatment approaches for allergies.
  • The upregulation of F13A1 in allergic horses suggests that modulation of the coagulation cascade could be a potential therapeutic strategy in managing allergic inflammation.
  • The downregulation of CCR10 in IgE-binding monocytes during the chronic disease phase implies that improving skin homeostasis might have therapeutic benefits for allergic reactions.

Cite This Article

APA
Simonin EM, Wagner B. (2023). IgE-binding monocytes upregulate the coagulation cascade in allergic horses. Genes Immun, 24(3), 130-138. https://doi.org/10.1038/s41435-023-00207-w

Publication

Genes and immunity
ISSN: 1476-5470
NlmUniqueID: 100953417
Country: England
Language: English
Volume: 24
Issue: 3
Pages: 130-138

Researcher Affiliations

Simonin, Elisabeth M
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Wagner, Bettina
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. bw73@cornell.edu.

MeSH Terms

  • Animals
  • Horses
  • Hypersensitivity / immunology
  • Hypersensitivity / veterinary
  • Up-Regulation
  • Monocytes / immunology
  • Immunoglobulin E / immunology
  • Sequence Analysis, RNA
  • Gene Expression Regulation
  • Transcription, Genetic

Grant Funding

  • S10 RR025502 / NCRR NIH HHS

Conflict of Interest Statement

The authors declare no competing interests.

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