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Animal genetics2010; 41 Suppl 2; 131-137; doi: 10.1111/j.1365-2052.2010.02122.x

IgE, IgGa, IgGb and IgG(T) serum antibody levels in offspring of two sires affected with equine recurrent airway obstruction.

Abstract: Equine recurrent airway obstruction (RAO) is a chronic lower airway disease of the horse caused by hypersensitivity reactions to inhaled stable dust, including mould spores such as Aspergillus fumigatus. The goals of this study were to investigate whether total serum IgE levels and allergen-specific IgE and IgG subclasses are influenced by genetic factors and/or RAO and whether quantitative trait loci (QTL) could be identified for these parameters. The offspring of two RAO-affected sires (S1: n=56 and S2: n=65) were grouped by stallion and disease status, and total serum IgE levels and specific IgE, IgGa, IgGb and IgG(T) levels against recombinant Aspergillus fumigatus 7 (rAspf7) were measured by ELISA. A panel of 315 microsatellite markers covering the 31 equine autosomes were used to genotype the stallions and their offspring. A whole-genome scan using half-sib regression interval mapping was performed for each of the IgG and IgE subclasses. There was no significant effect of disease status or sire on total IgE levels, but there was a significant effect of gender and age. rAspf7-specific IgGa levels were significantly higher in RAO-affected than in healthy horses. The offspring of S1 had significantly higher rAspf7-specific IgGa and IgE levels than those of S2. Five QTLs were significant chromosome-wide (P<0.01). QTLs for rAspf7-specific IgGa and IgE were identified on ECA 1, for rAspf7-specific IgGa and IgGb on ECA 24 and for rAspf7 IgGa on ECA 26. These results provide evidence for effects of disease status and genetics on allergen-specific IgGa and IgE.
© 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics.
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Publication Date: 2010-11-26 PubMed ID: 21070286DOI: 10.1111/j.1365-2052.2010.02122.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research was conducted to investigate the influence of genetic factors and the chronic lower airway disease in horses called recurrent airway obstruction (RAO) on certain types of serum antibodies. The study also aimed to identify specific genetic loci associated with these antibodies. The results suggest there are inherited influences on the antibodies specific to an allergen commonly found in dusty stables that can affect horses with RAO.

Objective and Methodology

  • The researchers set out to specifically investigate whether total serum IgE levels and allergen-specific IgE and IgG subclasses are influenced by genetic factors and/or RAO.
  • This goal in mind, they measured the subjects’ total serum IgE levels and specific IgE, IgGa, IgGb, and IgG(T) levels against a particular allergen found in mouldy stable dust using an ELISA analysis.
  • The subjects of this study were the offspring of two RAO-affected stallions. The team performed a whole-genome scan using half-sib regression interval mapping on each of the IgG and IgE subclasses for 315 microsatellite markers across 31 horse chromosomes.

Results

  • The total IgE levels were not significantly affected by disease status or the sire (stallion father) but were significantly influenced by gender and age.
  • Mould allergen-specific IgGa levels were notably higher in RAO-affected horses compared to healthy ones.
  • The children of Stallion 1 (S1) showed significantly higher allergen-specific IgGa and IgE levels than those of Stallion 2 (S2).
  • The research identified five quantitative trait loci (QTLs) on different chromosomes that were significant and an influence on the allergen-specific IgGa and IgE levels.

Implications

  • This study gives substantial evidence pointing towards the effects of disease status and genetics on allergen-specific IgGa and IgE antibodies. Understanding these influences may provide avenues for more effective treatment and prevention strategies for equine recurrent airway obstruction disease.
  • The findings regarding higher allergen-specific antibodies in RAO-affected horses indicate a possible role of these antibodies in the disease, which warrants further study.

Cite This Article

APA
Scharrenberg A, Gerber V, Swinburne JE, Wilson AD, Klukowska-Rötzler J, Laumen E, Marti E. (2010). IgE, IgGa, IgGb and IgG(T) serum antibody levels in offspring of two sires affected with equine recurrent airway obstruction. Anim Genet, 41 Suppl 2, 131-137. https://doi.org/10.1111/j.1365-2052.2010.02122.x

Publication

Animal genetics
ISSN: 1365-2052
NlmUniqueID: 8605704
Country: England
Language: English
Volume: 41 Suppl 2
Pages: 131-137

Researcher Affiliations

Scharrenberg, A
  • Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Berne, 3001 Berne, Switzerland.
Gerber, V
    Swinburne, J E
      Wilson, A D
        Klukowska-Rötzler, J
          Laumen, E
            Marti, E

              MeSH Terms

              • Airway Obstruction / genetics
              • Airway Obstruction / immunology
              • Airway Obstruction / veterinary
              • Allergens / immunology
              • Animals
              • Aspergillus fumigatus / immunology
              • Female
              • Horse Diseases / genetics
              • Horse Diseases / immunology
              • Horses
              • Immunoglobulin E / blood
              • Immunoglobulin G / blood
              • Immunoglobulin Isotypes / blood
              • Male
              • Quantitative Trait Loci

              Citations

              This article has been cited 12 times.
              1. Wyler M, Sage SE, Marti E, White S, Gerber V. Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma. J Vet Intern Med 2023 Jan;37(1):328-337.
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              2. Martins LML. Allergy to Fungi in Veterinary Medicine: Alternaria, Dermatophytes and Malassezia Pay the Bill!. J Fungi (Basel) 2022 Feb 27;8(3).
                doi: 10.3390/jof8030235pubmed: 35330237google scholar: lookup
              3. Sheats MK, Davis KU, Poole JA. Comparative Review of Asthma in Farmers and Horses. Curr Allergy Asthma Rep 2019 Oct 10;19(11):50.
                doi: 10.1007/s11882-019-0882-2pubmed: 31599358google scholar: lookup
              4. Verdon M, Lanz S, Rhyner C, Gerber V, Marti E. Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions. J Vet Intern Med 2019 Jan;33(1):266-274.
                doi: 10.1111/jvim.15355pubmed: 30520523google scholar: lookup
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                doi: 10.1111/all.12726pubmed: 26280544google scholar: lookup
              6. Jensen-Jarolim E, Einhorn L, Herrmann I, Thalhammer JG, Panakova L. Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities. Clin Transl Allergy 2015;5:15.
                doi: 10.1186/s13601-015-0059-6pubmed: 25852853google scholar: lookup
              7. Bosshard S, Gerber V. Evaluation of coughing and nasal discharge as early indicators for an increased risk to develop equine recurrent airway obstruction (RAO). J Vet Intern Med 2014 Mar-Apr;28(2):618-23.
                doi: 10.1111/jvim.12279pubmed: 24417562google scholar: lookup
              8. Wjst VF, Lübke S, Wagner B, Rhyner C, Jentsch MC, Arnold C, Lohmann KL, Schnabel CL. Aspergillus fumigatus antigen-reactive Th17 cells are enriched in bronchoalveolar lavage fluid in severe equine asthma. Front Immunol 2024;15:1367971.
                doi: 10.3389/fimmu.2024.1367971pubmed: 39229267google scholar: lookup
              9. Yoshida S, Matsuda A, Iwata E, Ono T, Hisaeda K, Ohzawa E, Hiasa Y, Kitagawa H. Allergen-specific immunoglobulin-Es for dermatitis in the Japanese native Noma horses. J Vet Med Sci 2024 Sep 1;86(9):938-945.
                doi: 10.1292/jvms.24-0107pubmed: 39010246google scholar: lookup
              10. Jentsch MC, Keilhaue A, Wagner B, Rhyner C, Lübke S, Karagulyan M, Arnold C, Lohmann KL, Schnabel CL. Aspergillus fumigatus binding IgA and IgG1 are increased in bronchoalveolar lavage fluid of horses with neutrophilic asthma. Front Immunol 2024;15:1406794.
                doi: 10.3389/fimmu.2024.1406794pubmed: 38953030google scholar: lookup
              11. Jentsch MC, Lübke S, Schrödl W, Volke D, Krizsan A, Hoffmann R, Kaiser-Thom S, Gerber V, Marti E, Wagner B, Schnabel CL. Immunoproteomics enable broad identification of new Aspergillus fumigatus antigens in severe equine asthma. Front Immunol 2024;15:1347164.
                doi: 10.3389/fimmu.2024.1347164pubmed: 38487534google scholar: lookup
              12. Schnabel CL, Jentsch MC, Lübke S, Kaiser-Thom S, Gerber V, Vrtala S, Huang HJ, Rhyner C, Wagner B, Hoffmann R, Volke D. Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides and yeast protein antigens in severe equine asthma in a preliminary study. Front Immunol 2023;14:1293684.
                doi: 10.3389/fimmu.2023.1293684pubmed: 38162673google scholar: lookup
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