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Home / Equine Research Bank / Front Immunol / IgE+ plasmablasts predict the onset of clinical allergy.
Frontiers in immunology2023; 14; 1104609; doi: 10.3389/fimmu.2023.1104609

IgE+ plasmablasts predict the onset of clinical allergy.

Abstract: IgE+ plasmablasts develop following allergen exposure and B cell activation. They secrete IgE and therefore are directly linked to maintain the mechanisms of IgE-mediated allergies. Here, we show that the presence of IgE+ plasmablasts in peripheral blood not only coincides with clinical allergy, but also predicts the upcoming development of clinical disease. Using an equine model of naturally occurring allergy, we compared the timing of allergen exposure, arrival of IgE+ plasmablasts in peripheral blood, and onset of clinical disease. We found that IgE+ plasmablasts predict the development of clinical allergy by at least 3 weeks and can be measured directly by flow cytometry or by IgE secretion following culture. We also compared the IgE secretion by IgE+ plasmablasts with total plasma IgE concentrations and found that while IgE secretion consistently correlates with clinical allergy, total plasma IgE does not. Together, we describe IgE+ plasmablasts as a reliable and sensitive predictive biomarker of allergic disease development.
Copyright © 2023 Simonin, Babasyan, Tarsillo and Wagner.
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Publication Date: 2023-02-02 PubMed ID: 36817463PubMed Central: PMC9932261DOI: 10.3389/fimmu.2023.1104609Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research shows that IgE+ plasmablasts, which are cells that secrete an antibody involved in allergic reactions, not only appear in the blood during an allergic response but can also predict the onset of clinical allergy symptoms. By studying these cells in horses, the scientists found that they could be measured in blood samples weeks before clinical symptoms appeared, and their activity was a more reliable indicator of future allergy symptoms than just measuring levels of the IgE antibody in the blood.

Study Design

The research was designed to investigate the relevance of IgE+ plasmablasts, a type of white blood cell, in predicting the onset of allergy symptoms. The study was conducted using an equine model of naturally occurring allergies.

  • The researchers examined the timing of allergen exposure (when the horse came into contact with substances that could trigger an allergic response)
  • The arrival of IgE+ plasmablasts in peripheral blood (the presence of these cells in the bloodstream), and
  • The onset of clinical disease (when allergy symptoms became obvious).

Key Findings

  • The main finding was that the presence of IgE+ plasmablasts in the blood could predict the development of allergy symptoms up to three weeks in advance.
  • These cells could be detected using flow cytometry, a laboratory technique that can count and sort cells, or measured by the IgE they secrete following the culture.
  • The study also compared the secretion of IgE by IgE+ plasmablasts with the total levels of IgE in the plasma. It was found that while the former consistently correlates with clinical allergy symptoms, the latter does not always do so.

Implications and Conclusion

The research suggests that IgE+ plasmablasts serve as a more reliable and sensitive marker for predicting the development of allergic diseases compared to just measuring the total IgE levels in the blood. This could potentially revolutionize the diagnosis and management of allergies, as the presence of these cells in the blood could serve as an early warning sign of an impending allergic reaction, allowing for pre-emptive treatment. Therefore, the scientists posit IgE+ plasmablasts as a valuable tool in the future study and management of allergies.

Cite This Article

APA
Simonin EM, Babasyan S, Tarsillo J, Wagner B. (2023). IgE+ plasmablasts predict the onset of clinical allergy. Front Immunol, 14, 1104609. https://doi.org/10.3389/fimmu.2023.1104609

Publication

Frontiers in immunology
ISSN: 1664-3224
NlmUniqueID: 101560960
Country: Switzerland
Language: English
Volume: 14
Pages: 1104609
PII: 1104609

Researcher Affiliations

Simonin, Elisabeth M
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Babasyan, Susanna
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Tarsillo, Justine
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Wagner, Bettina
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.

MeSH Terms

  • Animals
  • Horses
  • Immunoglobulin E
  • Hypersensitivity
  • Plasma Cells
  • Hypersensitivity, Immediate
  • Allergens

Conflict of Interest Statement

The authors ES, SB, and BW have submitted a patent application entitled ‘IgE+ plasmablasts as a predictive biomarker of allergy’ that uses technology described in this article. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 1 times.
  1. Simonin EM, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Freer H, Tarsillo J, Wagner B. Early allergen introduction overrides allergy predisposition in offspring of horses with Culicoides hypersensitivity. Front Immunol 2025;16:1654693.
    doi: 10.3389/fimmu.2025.1654693pubmed: 41194920google scholar: lookup
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