Immune escape of equine herpesvirus 1 and other herpesviruses of veterinary importance.
Abstract: Equine herpesvirus (EHV)-1 is a pathogen of horses, well known for its ability to induce abortion and nervous system disorders. Clinical signs may occur despite the presence of a virus-specific immune response in the horse. The current review will summarize the research, on how, EHV-1-infected cells can hide from recognition by the immune system. Research findings on immune evasion of EHV-1 will be compared with those of other herpesviruses of veterinary importance.
Publication Date: 2006-02-10 PubMed ID: 16472872DOI: 10.1016/j.vetimm.2006.01.006Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is about how the Equine Herpesvirus (EHV-1), which causes diseases in horses, has the ability to evade the immune system. The study also compares these evasion tactics with other significant veterinary herpesviruses.
Objectives of the Research
- The main objective of this research is to explore and understand how infected cells of the EHV-1 virus in horses can elude the detection of the immune system. In spite of having a virus-specific immune response, clinical symptoms still occur in horses.
- This paper aims to comprehensively review research studies that focus on the EHV-1 virus and its ability to escape the immune system’s recognition.
- The third goal of this study is to compare the immune evasion strategies of EHV-1 with those of other herpesviruses that hold significance in veterinary practices. This comparison will provide a broader perspective on understanding and tackling immune evasion in herpesviruses.
Significance of the Research
- The research is essential to enhancing our understanding of how EHV-1 and other similar herpesviruses can hide from the immune system. This knowledge can contribute to the improvement of medical treatments for horses infected with these viruses.
- By comparing the immune escape strategies of EHV-1 with other herpesviruses, the research could potentially uncover commonalities or patterns. These findings could lead to the development of comprehensive solutions to tackle not just one, but multiple herpesviruses.
Expected Outcomes of the Research
- One expected outcome of this research would be a detailed understanding of the mechanisms that enable EHV-1 and other similar herpesviruses to evade the immune system. This would be a significant step forward in treating viral infections in horses.
- Another possible outcome could be the identification of preventive steps or treatment methods to hinder the virus’s ability to dodge the immune system’s detection.
- The comparative review could also yield unique insights into the behavior and characteristics of these herpesviruses, potentially leading to new research pathways or therapeutic strategies.
Cite This Article
APA
van der Meulen KM, Favoreel HW, Pensaert MB, Nauwynck HJ.
(2006).
Immune escape of equine herpesvirus 1 and other herpesviruses of veterinary importance.
Vet Immunol Immunopathol, 111(1-2), 31-40.
https://doi.org/10.1016/j.vetimm.2006.01.006 Publication
Researcher Affiliations
- Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. karen.vandermeulen@ugent.be
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Cytokines / immunology
- Herpesviridae Infections / immunology
- Herpesviridae Infections / veterinary
- Herpesviridae Infections / virology
- Herpesvirus 1, Equid / immunology
- Horse Diseases / immunology
- Horse Diseases / virology
- Horses
- Viral Proteins / immunology
Citations
This article has been cited 6 times.- Pusterla N, Barnum S, Miller J, Varnell S, Dallap-Schaer B, Aceto H, Simeone A. Investigation of an EHV-1 Outbreak in the United States Caused by a New H(752) Genotype.. Pathogens 2021 Jun 13;10(6).
- Oladunni FS, Horohov DW, Chambers TM. EHV-1: A Constant Threat to the Horse Industry.. Front Microbiol 2019;10:2668.
- Spiesschaert B, Goldenbogen B, Taferner S, Schade M, Mahmoud M, Klipp E, Osterrieder N, Azab W. Role of gB and pUS3 in Equine Herpesvirus 1 Transfer between Peripheral Blood Mononuclear Cells and Endothelial Cells: a Dynamic In Vitro Model.. J Virol 2015 Dec;89(23):11899-908.
- Soboll Hussey G, Hussey SB, Wagner B, Horohov DW, Van de Walle GR, Osterrieder N, Goehring LS, Rao S, Lunn DP. Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant.. Vet Res 2011 Feb 7;42(1):23.
- Kurtz BM, Singletary LB, Kelly SD, Frampton AR Jr. Equus caballus major histocompatibility complex class I is an entry receptor for equine herpesvirus type 1.. J Virol 2010 Sep;84(18):9027-34.
- Brosnahan MM, Damiani A, van de Walle G, Erb H, Perkins GA, Osterrieder N. The effect of siRNA treatment on experimental equine herpesvirus type 1 (EHV-1) infection in horses.. Virus Res 2010 Feb;147(2):176-81.
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